Y. Gao

This study shows that Cavin1's intrinsically disordered domains are essential for caveola formation and trafficking through electrostatic interactions and phase separation.

The paper compares transcriptomic profiles of different human trophoblast development models to identify differentially expressed genes and transcription factors.

This study shows prior SARS-CoV-2 infection in golden hamsters provides partial protection but not sterilizing immunity, and virus can still be transmitted between infected and naive animals through direct contact.

This study compares gene expression between motile and non-motile cells in Bacillus subtilis, finding reduced ribosomal gene expression in motile cells, suggesting resource reallocation to motility systems.

This study develops an evolutionary model showing that costly cell differentiation, beneficial vegetative cells, and sufficient organism size are necessary for irreversible somatic differentiation.

This study identifies Cavin4's role in T-tubule formation and stability in skeletal muscle by showing its interaction with Bin1 and effects on caveolae remodeling.

This study shows Tim-3 promotes NF90 ubiquitination and degradation, inhibiting antiviral innate immunity via stress granule formation.

This study shows Ythdc1, an m6A reader, regulates LINE1 scaffold function in mouse ESCs, affecting self-renewal and differentiation through chromatin interactions.

This study identifies the CodY regulon in two closely related S. aureus USA300 strains, revealing conserved and strain-specific regulatory patterns and metabolic roles of CodY.

The paper investigates the oligomerization and structural properties of EspB, an ESX-1 substrate, revealing its role in forming a channel-like structure for ESX-1 secretion.

This study identifies NEURL4 as the main mitochondrial ADP-ribosyltransferase and shows it regulates mtDNA integrity through poly-ADP-ribosylation of mtLIG3.

The paper shows that exchanging viral backbone genes can increase neuraminidase content in influenza virions, leading to better NA antibody responses in mice.

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

This study investigates how environmental factors like light, temperature, depth, drought, and salt stress affect white clover seed germination and emergence, finding optimal conditions for successful establishment.

The paper identifies imprinted genes in flax endosperm and shows their role in intraspecific variation and domestication.

The paper identifies CXCL10+ perivascular clusters as Th1 activation niches that enhance T cell-APC interactions through IFN-gamma-dependent feedback.

This study characterizes plant-specific GIPC sphingolipids, showing they increase membrane thickness, electronegativity, and regulate phase transitions.

This study shows that dyclonine inhibits TRPV3 channels in keratinocytes, rescuing cell death and reducing pruritus in a mouse model.

The paper shows pancreatic cancer cells use transglutaminase-2 to create CXCL12-keratin 19 coatings that block T cells and resist immunotherapy.

This study shows that altering energy metabolism via IDH gene knockdown affects foraging behavior in termites, with social context modulating these effects.

This study develops BRAF-targeting PROTACs that degrade all BRAF mutants at sub-nanomolar concentrations while sparing wild-type RAF family members, showing in vivo efficacy and mechanistic insights.

The paper analyzes ANI values across microbial genomes and argues that the observed bimodal distribution does not support a universal genetic boundary due to sampling biases and inflated benchmarks.

The paper investigates denitrification in Bradyrhizobium isolates, finding that only ~1/3 can reduce N2O, with proteomics showing Nos outcompetes Nap for electrons.

This study identifies multi-site oxidations and amino acid substitutions in urinary proteins as age-related features by comparing three age groups using mass spectrometry and statistical analysis.

This paper identifies and characterizes the NIC1-locus in tobacco, showing it regulates nicotine biosynthesis through ERF genes that function downstream of NtMYC2 in the JA signaling pathway.

This paper improves an adenine base editor for in vivo use, achieving efficient dystrophin restoration in dystrophic mice with minimal off-target effects.

The paper presents a near-complete yeast proteome dataset using optimized sample preparation and high-resolution mass spectrometry, identifying 5610 proteins with 94.1% coverage of yeast ORFs.

This study examines the expression of Ace2, Tmprss2, and Furin in mouse ear tissues, finding co-expression in the middle ear that suggests susceptibility to SARS-CoV-2.

This study identifies lipid differences in plasma, microvesicles, and exosomes between preterm and full-term pregnancies, finding microvesicle lipids better predict preterm birth risk.