Y. Huang

The paper identifies Arl3 as a displacement factor that releases ODA16 from intraflagellar transport in Trypanosoma brucei.

The paper uses SpotLight proteomics to identify antibody sequences specific to deamidated human serum albumin, revealing insights into protein clearance and neurodegeneration prevention.

This study identifies two antibodies that neutralize all SARS-CoV-2 variants by locking the spike protein in a down conformation, showing a novel mechanism and potential for prophylaxis.

This study finds HBV can persist in cerebrospinal fluid, showing distinct mutations and resistance patterns compared to serum, and HIV co-infection increases resistance mutations in both compartments.

This study identifies two distinct subtypes of diffuse-type gastric cancer associated with CDH1 loss, highlighting T cell exhaustion and EZH2 regulon activation.

This study shows HCC-1 promotes atherosclerosis by inducing pyroptosis in endothelial cells and macrophages and suggests it as an early diagnostic biomarker.

This study uses plastome data to analyze the genetic diversity and phylogeny of Cibotium species in China, identifying cryptic species and lineage differentiation to aid conservation and breeding efforts.

The paper identifies a conserved neutralizing epitope on the S2 domain of SARS-CoV, SARS-CoV-2, and MERS-CoV spike proteins that is targeted by antibody 3A3.

This paper constructs a syntelog-based pan-genome of rice using long-read sequencing to study domestication and de-domestication, identifying introgression events and domestication genes.

This paper investigates a TRPM2 chanzyme from choanoflagellates, revealing how its enzymatic and channel functions are coupled through structural and kinetic mechanisms.

This paper introduces Alpha-LFM, a physics-aware deep learning framework for 3D super-resolution imaging of living cells, achieving high resolution, speed, and low phototoxicity over long periods.

This study shows plant diversity stabilizes soil temperature by increasing organic carbon and leaf area index, with effects strengthening over time and under extreme conditions.

This study shows that the lncRNA APOLO regulates auxin-related genes involved in shade avoidance syndrome in Arabidopsis thaliana by modulating chromatin structure and gene expression.

This paper introduces a self-healing PDMS material with safety-enhancing properties for wireless, skin-interfaced bioelectronic devices.

The paper shows that m6A and YTHDF2 regulate DUSP1 to enhance innate immune response during infections by promoting DUSP1 degradation and activating MAPKs.

This study shows CD99 regulates protein synthesis in hematopoietic stem cells and leukemia stem cells, promoting self-renewal and clonal expansion leading to AML.

This study shows that CRACD, an actin regulator, suppresses neuroendocrine plasticity and immune evasion in SCLC by modulating NOTCH1 and EZH2 pathways, suggesting EZH2 blockade as a potential therapy.

This study investigates X-ray-induced bubble formation in soft tissues using combined imaging and gas analysis, showing vacuum degassing delays bubble nucleation and reveals dose-controlled growth mechanisms.

This study shows that 2,4-DTBP induces adipogenesis in human MSCs by activating RXR, suggesting it as an obesogen and endocrine disruptor.

This study identifies HEV-ORF3 as a prion-like protein that facilitates virion release and pathogenesis by forming filamentous structures, highlighting its role in viral assembly.

This study shows that reduced Prolyl oligopeptidase (POP) and its product Ac-SDKP contribute to ovarian fibrosis in PCOS mice by altering MMP-2 and TGF-β1 expression.

The paper identifies lipoproteins transported to the cell surface via LptDE and reveals a crosstalk between Lpt and Lol pathways in Gram-negative bacteria.

This study shows PD-L1 maintains IFN-gamma signaling in human pluripotent stem cell-derived macrophages, essential for their development and inflammatory function.

This paper uses CpHMD simulations to identify H168 as an interior pH sensor in hHv1, supporting previous electrophysiological findings.

This study examines how different developmental temperatures affect survival and morphology in Heliconius erato butterflies, finding higher egg and larval mortality at higher temperatures and morphological changes in adults.

The paper shows that mitochondrial H2O2 oxidizes H3.1 at Cys96, promoting chromatin remodeling, breast cancer metastasis, and drug resistance.

This paper develops and benchmarks a high-throughput, robust proteomics method using Zeno SWATH DIA for analyzing cynomolgus monkey and human samples, showing improved sensitivity and coverage for metabolic disease studies.

This study designs a modified SARS-CoV-2 Spike antigen with increased RBD exposure and immunogenicity, showing improved neutralizing antibody responses in mice.

This study shows that LNP-based vaccines induce time- and dose-dependent anti-PEG antibodies in rats, with immune memory and accelerated blood clearance upon re-injection.

This study shows that new SARS-CoV-2 BQ and XBB subvariants have significantly reduced neutralization by vaccines and monoclonal antibodies, suggesting a threat to current immunity.