Y. Li

The paper identifies reduced ER-mitochondria contacts as a mechanism promoting neuroblastoma multidrug resistance by impairing Ca2+ transfer and apoptosis.

The paper investigates syncytia formation between SARS-CoV-2 infected and ACE2-expressing cells, finding that it leads to pyroptosis via Caspase-9 and GSDME activation, contributing to severe COVID-19 inflammation.

This study evaluates the fertility of bovine ejaculates with low vs. very low progressive motility, finding similar embryo development but higher blastocyst rates in the control group.

This paper introduces a method to visualize multiple proteins at synapses using DNA-assisted single-molecule localization microscopy, enabling high-resolution imaging of neuronal tissue sections.

The paper identifies epidermal green autofluorescence as a novel non-invasive biomarker for detecting local skin inflammation using a mouse model.

The paper shows SA proteins interact with RNA and R-loops to promote cohesin loading independently of NIPBL, revealing a new role in chromatin structure and cancer biology.

This study shows peritumoral myofibroblasts suppress iCCA growth but promote metastasis through Vcam1-dependent mechanisms.

This paper describes an AAV-mediated in vivo CAR gene therapy that generates CAR T cells within the host, leading to tumor regression in a humanized mouse model.

This study identifies potent non-covalent SARS-CoV-2 PLpro inhibitors that block viral replication in human and monkey cell cultures with low nanomolar potency.

This study investigates how SARS-CoV-2 N-protein interacts with nucleic acids to form supramolecular clusters and phase-separated droplets, revealing structural and energetic changes during assembly.

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.

This paper develops a transferrable I-F Cascade system for genome editing and transcription modulation in P. aeruginosa, showing improved efficiency and versatility over Cas9.

This study develops self-assembling SARS-CoV-2 nanoparticle vaccines that induce protective immunity in mice through subcutaneous and oral administration.

Eliglustat inhibits autophagy in osteoclasts, reducing MM bone disease and suggesting its use as a treatment for bone loss disorders.

This study compares knowledge and awareness of COVID-19 between Chinese dental students and nonmedical students, finding dental students scored higher overall but had weaknesses in treatment and prevention.

This study identifies dynamic histone acetylation as a mechanism coordinating primary and secondary metabolic pathways in petunia flowers to regulate volatile compound synthesis and emission.

A one-year observation of coastal microbial communities revealed similar but different community dynamics for eukaryotes, a group of large viruses, and prokaryotes.

This study shows ESD1 regulates seed setting rate in rice by controlling embryo sac development, as loss-of-function mutants exhibit reduced seed setting rates and abnormal embryo sac differentiation.

This study shows that GS-441524, a metabolite of remdesivir, effectively inhibits SARS-CoV-2 in cell cultures and mice, suggesting it may contribute to remdesivir's antiviral activity.

The paper identifies two early rabies infection cases in raccoons using LN34 RT-qPCR, showing higher viral levels in caudal brain regions and confirming low-level infections.

This study identifies that TNBC cells recruit neutrophils by secreting TGF-β and CXCR2 ligands, promoting tumor progression.

The paper classifies neoantigens based on immune interactions and improves their prioritization for cancer immunotherapy.

This study evaluates how SARS-CoV-2 variants bind animal ACE2 proteins and their sensitivity to neutralizing antibodies and ACE2-Ig constructs, finding increased ACE2 affinity and partial resistance to antibodies but enhanced neutralization by ACE2-Ig.

The paper identifies mutations in FtsW and FtsI that reveal the activation mechanism of the SEDS-bPBP complex FtsWI, showing it relies on an interaction between FtsW's ECL4 and FtsI's pedestal domain.

This paper develops a chip-based system combining microfluidics and light-field microscopy with deep learning to high-speed 4D image and analyze moving C. elegans.

The paper uses computational and experimental methods to control bacterial microcompartment assembly by modifying protein interactions and angles.

This study reports cryo-EM structures of CALHM1 channels and proposes a mechanism for ATP permeation through dynamic N-helix movement.

This study shows Tim-3 promotes NF90 ubiquitination and degradation, inhibiting antiviral innate immunity via stress granule formation.