Y. Li

This study identifies SUMOylation of EPAC1 at K561 as a mechanism for cAMP-independent activation of EPAC1 through enhanced Rap1 interaction.

This paper shows that combining dietary restriction of arginine and proline with polyamine depletion drugs enhances tumor differentiation and survival in a neuroblastoma mouse model by disrupting oncogenic translation.

This study identifies CD177 as a novel IgG Fc receptor and shows that genetic variants in CD177 affect IgG-mediated functions like ADCC.

The paper identifies ASAP1 as a specific binder of gAnkB, revealing structural and functional insights into their interaction and potential roles in axonal cytoskeleton regulation.

This paper develops a stabilized RH5 VLP vaccine that induces improved anti-malarial antibodies compared to a soluble protein vaccine in preclinical studies.

This study shows that Omicron variant-matched boosters after prototype mRNA vaccines induce cross-neutralizing antibodies against SARS-CoV-2 and sarbecoviruses by imprinting prior immune responses.

This paper introduces M3-CAD, a deep learning pipeline for designing multi-mechanism antimicrobial peptides to combat multidrug-resistant organisms, showing effectiveness in a skin wound infection model.

This study shows that ARAP1 regulates circular dorsal ruffles in Hep3B cells, and its deletion reduces malignant potential, suggesting CDRs contribute to cancer development through nutrient uptake.

This paper reviews the research history, distribution, and ecological impacts of invasive apple snails, highlighting gaps in understanding and the need for further study.

The paper uses single-molecule imaging and molecular dynamics simulations to study early MET receptor activation in situ, revealing structural dynamics and a refined dimer model.

This study uses phylogenomic data to reconstruct the evolutionary history of caddisflies, finding that portable case-making evolved independently in three lineages.

This paper introduces a non-viral CRISPR/Cas9 method using cationic polymers to generate mouse lung cancer models by inactivating tumor suppressor genes, enabling rapid and flexible hypothesis testing.

The paper assesses how climate change affects tropical forest community persistence by analyzing plant-plant interaction networks and structural stability over 25 years.

This study uses cryo-ET and STEM-EDS to reveal the ultrastructural morphology and elemental composition of Nitrosopumilus maritimus SCM1, identifying two types of storage granules.

This study shows ECM1 prevents hepatic fibrosis by inhibiting TGF-β1 activation, with implications for developing safe anti-fibrotic therapies.

This study identifies Aff3ir as a novel gene involved in endothelial cell differentiation by enhancing vascular stem/progenitor cell differentiation in mice.

This study identifies umbrella toxin particles produced by Streptomyces that inhibit the growth of competing bacterial species, distinct from small molecule antibiotics.

This paper identifies a novel SPI-2 effector, SseM, in Salmonella that interacts with the dystrophin-associated protein complex and modulates bacterial growth in mice.

This study shows that inhibiting HDAC10 increases SPARC expression, which suppresses melanoma growth and restores sensitivity to BRAF inhibitors.

This paper introduces a high-speed 3DSIM system using DMD and electro-optic modulators, achieving improved resolution and imaging speed for various biological specimens.

This study shows that targeting endothelial FOXO1 reduces IGF2 levels, improves β-cell function, and enhances wound healing in diabetes.

This study compares transcriptomics, proteomics, and phosphoproteomics responses in HepG2 and AC16 cells to chemical exposure, finding phosphoproteomics changes occur earlier and at lower concentrations than transcriptomics.

This paper introduces FISH-scRACS-Seq, a method to identify and sequence single cells with specific metabolic functions, revealing a new cyclohexane-degrading enzyme system in marine bacteria.

The paper uses multiomic single-cell sequencing to analyze SJS/TEN patients' skin and blister fluid, identifying tissue-specific immune responses and T-cell clonotypes involved in pathogenesis.

This study investigates how a coordinated switch in sucrose and callose metabolism enhances symplastic unloading in potato tubers, contributing to sink strength.

The paper designs an intranasal pan-coronavirus vaccine using epitopes from SARS-CoV-2 and zoonotic coronaviruses, showing immune responses in mice but needing further cross-reactivity testing.

This study investigates VSTM deficits in aMCI patients, finding reduced accuracy and capacity linked to MTL atrophy and prefrontal compensation.

The paper redesigns hypervariable loops in HIV-1 Env consensus sequences to enhance antibody binding and improve vaccine antigen design.

This study identifies human α-cell and β-cell subtypes and trajectories using integrated scRNA-seq and snRNA-seq, revealing gene signatures for interconversion and highlighting in vivo transitions in T2D.

This study identifies pyrimethamine as an NRF2 inhibitor that suppresses esophageal hyperplasia in a mouse model and shows potential for clinical use in NRF2-high ESCC.