Y. Wang

This study develops two quadrivalent mRNA vaccines against monkeypox virus and shows they induce antibodies, cellular immunity, and protection against Vaccinia virus in mice.

The paper identifies a lncRNA, TREX, as a biomarker predicting in vivo efficacy of RPE cell transplantation and shows its impact on cell integration.

The paper identifies two Keap1 isoforms that interact with Smad2/3, enhancing their stability and transcriptional activity, and reveals a novel crosstalk between the Keap1-Nrf2 and TGF-β1-Smad2/3 pathways.

This study shows that Notch receptors can be activated by multivalent Jag1 ligand clusters without requiring mechanical force, using iPSc-derived cells and DNA origami patterns.

This study shows O-GlcNAcylation of YTHDF1 enhances its cytosolic localization and promotes colorectal cancer by increasing c-Myc expression.

The paper analyzes AGF diversity across 661 fecal samples from 34 herbivorous species, identifying 56 novel genera and showing that both stochastic and deterministic processes shape AGF communities, with hindgut fermenters having stronger host-specific associations.

The paper develops improved protocols and analysis pipelines to study adjuvant effects on murine Ig repertoires, finding distinct impacts of CpG and Alum on tissue and isotype-specific IgG and IgM repertoires.

This study shows that combining mesenchymal stromal cells and alpha-1 antitrypsin significantly improves inflammation modulation and resolution in vitro and in a mouse model.

This study investigates the evolutionary history and metabolic diversity of Bathyarchaeia, linking their diversification to geological events and environmental changes.

This paper introduces a 3D spheroid-microvasculature-on-a-chip model to study tumor-endothelium mechanobiology interactions under controlled flow conditions.

The paper tests SARS-CoV-2 exposure in NYC rats, finding 16.5% seropositive and partial genomes in some, and shows rat susceptibility to Alpha, Delta, and Omicron variants.

This paper demonstrates that planarians can navigate to a previously recognized location in a new maze, indicating they have spatial localization ability.

This study identifies a signaling cascade involving GxcM, Fbp17, RacC, and WASP that regulates rear cortical actin assembly in migrating Dictyostelium cells.

This study identifies molecular mechanisms of Zika virus-induced oncolysis in neuroblastoma and highlights a promising oncolytic virotherapy candidate.

This study examines bacterial motion in microsphere-mimicked porous media, finding reduced velocity and increased directional changes with higher microsphere density, and establishes a correlation between bacterial trapping and geometric confinement.

The paper investigates how microtubule binding affects LIS1 dissociation from dynein, showing that MT-bound dynein has low LIS1 affinity while MT-unbound dynein binds LIS1 strongly.

This paper presents a high-density fan-out strategy for flexible microelectrodes, reducing packaging volume and enabling 1024-channel recording with 100% connection success.

This study identifies SlG1 as a root-specific GGPP synthase that interacts with PSY3 to produce strigolactones in tomato roots, without affecting ABA or shoot development.

This study uses network pharmacology and in vitro experiments to identify Qionggui Power's active ingredients and mechanisms against atherosclerosis, showing suppression of the NF-κB pathway.

This study identifies two groups of metabolites in lamprey buccal glands that modulate host responses and establishes a spatial metabolomics database for lamprey research.

This study uses a rodent model of hyperglycemia to show that proinsulin trafficking is delayed at the Golgi, contributing to beta-cell secretory dysfunction in Type 2 diabetes.

This study shows high air humidity reduces plant resistance by inhibiting salicylic acid signaling through altered NPR1 protein function in Arabidopsis.

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

This study identifies PhoP as a key regulator of pathogenicity in Riemerella anatipestifer by combining DAP-seq and transcriptome analysis, showing its role in aerotolerance and virulence.

This study cultivates a Bathyarchaeia strain capable of degrading lignin via a novel methyltransferase system, suggesting its role in global anaerobic lignin remineralization.

This study evaluates the impact of Fcγ receptor affinity on CAR T cell efficacy and safety, finding that moderate affinity provides optimal antitumor activity while high affinity causes toxicity.

This study identifies and characterizes circRNAs in moso bamboo, their biogenesis, function, and response to gibberellins and auxins.

This study shows a nanoparticle vaccine induces broad neutralizing antibodies against multiple SARS-CoV-2 variants and protects non-human primates and mice from viral challenges.

The paper investigates the correlation between skin and musk glands in Chinese forest musk deer, finding strong gene expression overlap and roles for Sox9, Caveolin1, and AR in both tissues.

This study identifies intronless ERF transcription factors as a molecular tool used in the evolution of C4 photosynthesis in multiple plant lineages.