Y. Wang

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

The paper identifies CRIHSP structures in human adaptive immunity genes, showing their association with genomic instability and recombination.

The paper determines the structure of AtABCG25, an ABA exporter, revealing its mechanism of ABA binding and transport through cryo-EM.

This paper introduces a voxelated bioprinting method to create double-network hydrogel droplets with precise 3D assembly and mechanical properties.

This study identifies a novel human antibody, AF-03, that targets MARV glycoprotein and shows neutralizing activity against MARV and related filoviruses.

This study investigates Erdr1's role in macrophage polarization and cell fate by showing it promotes IL-1β production in a dose- and density-dependent manner through interactions with YAP1 and Mid1.

The paper identifies RNA methylation and autophagy-related genes in COPD using bulk and single-cell RNA sequencing data and validates them in animal models.

This study shows NGAL deficiency causes Hemophilia-like bleeding and clotting issues by enhancing coagulation and suppressing antithrombin.

The paper determines cryo-EM structures of P2X7 receptor with antagonists and identifies key residues for subtype specificity, aiding in antagonist design.

The paper predicts three new mammalian echolocators using molecular convergence analyses and machine learning, with behavioral experiments confirming echolocation in shrew moles.

This study identifies glucocorticoid receptor activation in NK cells as a mechanism driving AREG-mediated immunosuppression in skin cancer, with therapeutic implications.

This study identifies two modules, Cep131-Cep162 and Cby-Fam92, that cooperatively maintain Cep290 at the basal body and initiate ciliogenesis.

This study curates a dataset of influenza HA antibodies and develops an explainable language model to predict antibody specificity, identifying and validating HA stem antibodies.

This study shows that IL-23 receptor signaling in ILC3s enables them to produce IFNγ and clear the live-attenuated oral Chlamydia vaccine intrOv from the gut, ensuring its safety.

The paper develops predictive models for protein-protein binding affinity using amino acid composition at interfaces and identifies key amino acids that influence binding strength.

This study identifies the CD36-PKM2-mtROS pathway as a mechanism by which oxidized LDL disrupts efferocytosis, contributing to atherosclerosis progression.

The paper identifies a new type of monocytic leukemia stem cell (m-LSC) in AML patients treated with venetoclax, showing its distinct characteristics and clinical relevance.

This study identifies ABA and BR as key regulators in overcoming inter-subgeneric hybridization barriers in water lily through transcriptomic and hormonal analyses.

This study shows that bacterial sphingolipids worsen colitis by reducing IL-22 production from ILC3 cells in mice.

This study analyzes stromal cells in renal cell carcinoma to identify molecular features and construct a prognostic model for clinical risk estimation.

This study demonstrates longitudinal awake mouse brain imaging using ultrasound localization microscopy, showing reduced vessel density and flow velocity after anesthesia recovery.

This study characterizes the antigenic properties and infectivity of the SARS-CoV-2 BA.2.86 variant, finding it evades immune responses but has reduced infectivity compared to previous variants.

This study identifies a mechanism where cytoskeletal activation of NHE1 drives secondary volume increase and affects cell proliferation in response to hypotonic stress.

This study shows that convergent evolution of SARS-CoV-2 XBB lineages at RBD positions 455-456 synergistically enhances antibody evasion and ACE2 binding through epistatic interactions.

The paper identifies myostatin as an endocrine hormone that promotes pituitary FSH synthesis and ovarian function, challenging the previous role of activins and highlighting potential fertility risks of myostatin antagonists.

This paper derives an exact solution for a three-stage stochastic gene expression model that includes cell-cycle dynamics, showing discrepancies with the classical model that ignores cell-cycle effects.

This paper identifies novel anaerobic gut fungi in tortoises, revealing their ancient evolutionary origin and reduced metabolic capabilities compared to mammalian counterparts.

This study shows that titanium dioxide nanoparticles induce fat deposition in mice by increasing ROS and activating the AGE-RAGE pathway, with NAC as a potential therapeutic.

This study develops a PET/CT method to track up to 20 single cells throughout the body, demonstrating its use in tracking melanoma cells and their distribution in various organ systems.

This paper develops a method for spatial lipidomics of undecalcified spines using mass spectrometry imaging, revealing lipidomic profiles at 10 micrometer resolution.