Y. Wang

This study identifies a minimal bacterial consortium that efficiently drives nitritation at acidic pH through metabolic interactions and stress adaptation mechanisms.

This study presents cryo-EM structures of VMAT2 bound to substrates and inhibitors, revealing conformational changes and mechanisms of ligand recognition and inhibition.

This study shows that PYK2 and FAK regulate breast cancer metastasis through distinct mechanisms, with PYK2 affecting motility and FAK reducing tumor size and metastasis.

This paper introduces SFE-Net and SFT-DFCAN to estimate and correct optical aberrations in live-cell imaging without additional hardware, achieving fast and accurate super-resolution.

This study identifies a bioactive peptide from a pearl oyster that inhibits SARS-CoV-2 infection and enhances ACE2 activity to treat related complications.

This study uses proteomic profiling to stratify small cell lung cancer into three subtypes with distinct clinical outcomes and treatment responses, identifying potential therapeutic targets and improving prognosis prediction.

This study identifies ROCK1 activation as a driver of mitochondrial fission and oxidative stress in CKD-induced muscle wasting, showing pharmacological inhibition of ROCK1 can alleviate these effects.

The paper presents high-resolution cryo-EM structures of human muscle phosphorylase kinase, revealing its architecture and activation mechanism through conformational changes and allosteric regulation.

This study shows Prdm1 regulates liver cNK cells and ILC1s, affecting cancer metastasis and immune communication, with implications for liver cancer immunotherapy.

The paper studies allopolyploidization in weeping willow, showing how sex chromosomes evolve and revert after hybridization between two dioecious species.

This paper introduces PELSA, a peptide-centric local stability assay that identifies ligand-binding regions across the proteome with high sensitivity and without ligand modification.

This study identifies RAD18's role in TMZ resistance and hypermutation in GBM by linking it to TLS and MMR pathways through CRISPR screening and mutation analysis.

This study shows STING activates NFkB signaling via HOIP-mediated M1 ubiquitin chains on Golgi membranes, independent of LC3B lipidation.

The paper reports the structures of ten protein complexes from spinach leaves using a new ex vivo method that enables cryoEM-based high-resolution structure determination without genome manipulation or high-affinity binders.

This study investigates RANKL's role in lung epithelial cell regeneration, finding it promotes type II alveolar epithelial cell regeneration and may contribute to lung tissue repair.

The paper assembles gap-free X and Y chromosomes of Salix arbutifolia, revealing evolutionary changes in sex determination from XY to ZW without altering the sex-determining region.

The paper identifies a novel ACE-inhibitory peptide from pearl matrix and demonstrates its potential as an antihypertensive agent.

This study identifies RAP2 GTPase as a central integrator of cytoskeletal signals in Hippo pathway regulation, showing its role in mediating responses to cytoskeletal changes and its impact on Hippo kinase activity.

This study identifies shared and distinct mechanisms of UBA1 inactivation in VEXAS syndrome and related diseases, revealing how different mutations affect ubiquitin transfer to E2 enzymes.

The paper develops a CRISPR/Cas9 system for Arabidopsis using the NUC1 promoter, achieving high editing efficiency and stable inheritance in the T2 generation.

This study shows that renal fibrosis induced by injury promotes cyst formation and growth in adult ADPKD mice, and targeting EZH2 can reduce fibrosis and cyst growth.

This study shows that warming reduces fungal abundance and shifts fungal community composition in semi-arid grasslands, leading to reduced soil carbon efflux.

This study links psychosocial experiences to mitochondrial biology in the human brain, finding positive experiences correlate with higher OxPhos machinery abundance and negative experiences with lower abundance.

The paper identifies elevated MMPs and NETs in CNS-TB patients and shows MMP inhibition improves survival in a mouse model.

This study investigates the role of liver-specific glucocorticoid receptor (GR) in alcoholic liver disease using knockout and knockin mice, finding that GR deficiency worsens steatosis and liver injury while GR overexpression provides protection.

The paper investigates the role of mixotrophic eukaryotes as bacterivores in a coastal region, finding they contribute significantly to bacterivory despite being less dominant than heterotrophs.

This study shows that non-core RAG regions reduce off-target V(D)J recombination and maintain genomic stability in BCR-ABL1+ B-ALL by improving RAG cleavage accuracy.

This paper presents the first telomere-to-telomere genome assembly of the soybean cultivar Zhonghuang 13, resolving gaps and identifying novel genes and structural variations.

This study exposes M.tb strains to human alveolar lining fluid and finds strain-specific and time-dependent gene expression changes, particularly in lipid metabolism and cholesterol degradation.

This study identifies SASH1 as a regulator of melanocyte stem cell maintenance, showing that the S519N variant disrupts its function and links to pigmentation disorders.