Y. Wang

This paper develops a conditional MHC class II knockout mouse to study cell-specific and time-dependent adaptive immune responses in peripheral nerves, showing resistance to autoimmune neuropathy despite MHC class II expression.

This study identifies miPEP156e, a miRNA-encoded peptide in rice, which enhances cadmium tolerance by modulating ROS and Cd transporter genes.

This study develops a high-throughput screening platform to identify anti-fibrotic compounds by quantifying myofibroblast contractility in response to TGF-β1.

This paper identifies AMPK's role in shifting carbon utilization from glucose to glutamine via PDZD8 phosphorylation, enhancing glutaminolysis and extending lifespan in C. elegans and mice.

This study shows that fecal virome transplantation can alter gut microbiota and influence lean or obese body phenotypes in mice.

The paper constructs a mathematical model to predict tumor control patterns based on CTL killing mechanisms and evaluates therapeutic outcomes under immune checkpoint blockade.

The paper analyzes population genomes and epigenomes of Spirodela polyrhiza to show low genomic diversity and DNA methylation levels, with natural selection shaping asexual reproduction traits.

This study identifies metabolic perturbations in PWB-derived iPSCs, showing upregulated glutathione and downregulated sphingolipid metabolism, which may contribute to laser resistance in PWB vasculature.

This study evaluates culture and RNA isolation methods for cirrhotic precision-cut liver slices, finding that insulin and dexamethasone improve albumin production and gene expression.

The paper assesses the distribution and genetic diversity of Hipposideros pratti in its northernmost range, finding limited distribution, low genetic diversity, and human threats.

This study identifies HSPB1 as a driver of chemoresistance in breast cancer by inhibiting ferroptosis and activating NF-κB signaling.

This study shows that combining proguanil and chlorhexidine with clarithromycin or rifampicin enhances antibacterial activity against Acinetobacter baumannii in vitro and improves treatment outcomes in mice.

This study identifies SMU_1361c as a transcriptional repressor regulating oxidative stress response in Streptococcus mutans, showing its role in pathogenesis and potential for therapeutic development.

This study determines the cryo-EM structures of ATG2A and ATG2A-ATG9A complexes, revealing their roles in lipid transfer during autophagosome formation.

This study investigates how specific mGlu1 mutations affect receptor function in SCA subtypes, revealing distinct mechanisms and potential therapeutic strategies using allosteric modulators.

The paper determines the cryo-EM structure of mouse TMEM63C, reveals structural differences from plant orthologues, and shows TMEM63C functions as a monomer while TMEM63B is a mix of monomer and dimer.

This study identifies mechanical sensing via Piezo1 as critical for lung-specific neutrophils to maintain pulmonary homeostasis and respond to infection.

This study generates iPSCs from PWB fibroblasts and differentiates them into ECs that recapitulate disease phenotypes, identifying dysregulated pathways and genes involved in vascular malformations.

This study examines sugar assimilation in Neotropical bats, revealing metabolic adaptations to different diets through glucose tolerance tests, genome analysis, and gene expression studies.

This paper develops a microfluidic chemostatic bioreactor for high-throughput screening of microalgal growth and lipid production, achieving higher throughput and efficiency compared to traditional methods.

This study determines the crystal structures of A2AR with AB928 and 2-118, revealing distinct binding modes on A2AR and A2BR that explain AB928's dual-antagonistic properties.

This study shows that LRRK2 G2019S promotes colon cancer by enhancing intestinal inflammation and tumor growth in mice.

This study shows that myeloid HDAC3 deficiency protects against angiotensin II-induced kidney inflammation and fibrosis in mice.

This study shows that left-handed graphene quantum dots (L-GQDs) have higher diffusion and drug delivery efficacy in tumor-like spheroids compared to right-handed D-GQDs.

The paper identifies a recombinant human astrovirus type 5 strain from an acute gastroenteritis outbreak in Beijing, China, showing genetic clustering with HAstV-1 and HAstV-5.

This study shows that inhibiting HOTAIR and EZH2 reduces ovarian cancer stem cell resistance to platinum chemotherapy and improves survival in vivo.

This study shows TECPR1 can substitute for ATG16L1 to conjugate LC3 to damaged lysosomes by providing E3-ligase activity to the ATG5-ATG12 complex.

This paper deletes the I196L gene from ASFV SY18, resulting in a less virulent recombinant virus that protects pigs against ASFV challenge.

Tirzepatide reduces tumor growth in obese mice by decreasing food intake and metabolic hormones, but not by directly inhibiting cancer cell proliferation.

This paper develops FUS-CRISPR(a/i) tools to remotely control gene expression and epigenetic modifications in vivo, showing therapeutic effects in tumor models.