Y. Wang

This paper develops a CAR-T therapy for gastrointestinal cancers by combining CLDN18.2 targeting with synthetic NKG2D receptors containing DAP10 and DAP12 domains, improving efficacy against heterogeneous tumors.

The paper shows that inactivating three negative regulators of cortical branched actin enhances migration persistence in human and zebrafish cells, with vimentin down-regulation contributing to the stable maintenance of this phenotype.

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

This paper develops a deep learning pipeline to rapidly characterize dynamic DNA nanodevices by detecting particles and estimating their conformation from images.

This study uses single-cell multi-omics to map epigenetic and transcriptomic changes in retinoblastoma, identifying key regulators and potential drug targets.

KLIPP uses CRISPR/Cas9 to target cancer-specific structural variant junctions, inducing DNA breaks and cell death in tumor cells with high specificity.

The paper identifies an immunosuppressive class of glioblastoma (IDC) with high anti-inflammatory cytokine expression and poor prognosis, suggesting resistance to immune checkpoint blockade therapy.

This study identifies a murine gut protozoan that alleviates Clostridium difficile infection by modulating arginine metabolism and host immune responses.

The paper identifies a modular (L)WY-LWY motif in Phytophthora effectors that recruits host PP2A phosphatase, enabling phosphoprotein regulation through structural mimicry.

The paper genetically manipulates Saccharibacteria from the CPR to study their role in epibiotic growth and develops bioinformatic resources for their analysis.

This paper demonstrates the use of ribozymes to synthesize both L- and D-amino acid oligos by facilitating peptide ligation through RNA-RNA proximity.

This study investigates how rapid cold hardening (RCH) affects anoxia-induced spreading depolarization in locusts by examining ion regulation mechanisms.

The paper shows that salt stress modulates lateral root development through an auxin-independent pathway involving ZAT6 and LBD16.

This study identifies RLCK-VII subfamily members as essential for ROS production and signaling downstream of the Cf-4 resistance protein in N. benthamiana.

The paper reports cryo-EM structures of the Schizosaccharomyces pombe Clr6S complex, revealing its active site and interactions with a nucleosome.

This paper introduces LOCA-ULM, a deep learning method for ultrasound localization microscopy that improves microbubble detection and localization accuracy in vivo and in silico.

This study investigates the role of IGF2R in myocardial ischemia-reperfusion injury, finding it promotes inflammation and fibrosis and is a potential therapeutic target.

This study shows the retinal pigment epithelium uses proline nitrogen to produce and export amino acids to the neural retina, highlighting its role in retinal metabolism.

This paper develops Au-CS@FNDs contact lens additives to block UV, prevent bacterial keratitis, and inhibit corneal neovascularization.

This study generates the first germ-free marine medaka models from larvae to adults and identifies developmental and transcriptomic differences caused by the absence of gut microbiota.

The paper uses computational methods to analyze mRNA sequences of bacterial type III and IV effectors, finding that type III effectors show high frameshift tolerance in secretion signals, while type IV show low tolerance.

The paper shows doxorubicin inhibits MoPSD2, a phosphatidylserine decarboxylase in Magnaporthe oryzae, reducing fungal growth and crop disease severity.

This study examines Listeria species in beach sand, identifying hypervirulent isolates and their potential role in human listeriosis.

This study shows that loss of myeloid CB1 receptor reduces atherosclerosis in male mice by limiting macrophage proliferation and inflammation, with sex-specific effects observed.

This paper develops a method to generate human alveolar macrophage-like cells in vitro using lung lipids and cytokines, enabling study of lung inflammatory diseases and infections.

The paper identifies adaptive pathways in metabolic liver disease by selecting somatically mutated clones in mice and humans, finding mutations that ameliorate lipotoxicity and promote clonal expansion.

This study shows that p38α inhibition reduces immunosuppression by MDSCs and enhances immunotherapy in TNBC by decreasing CXCL1/CXCL2 expression.

This study tracks microbial colonization in neonatal calves and identifies genetic links between microbes and host metabolites affecting health and growth.

This study shows that early microbial intervention in newborn calves reduces diarrhea and improves later milk production by altering gut microbiome composition and metabolite profiles.

This study models how counterions and solvent dielectric affect charge transport in DNA, showing counterions have little effect in solution but influence electron transmission in dry DNA.