Y. Wang

This study evolves Bacillus subtilis in co-culture with Aspergillus niger, finding enhanced surfactin production and surface spreading that inhibit fungal growth.

This study uses scRNA-seq to classify PCCs into metabolism-type and kinase-type based on molecular features and microenvironment characteristics, suggesting potential therapeutic strategies.

This paper introduces a one-step genome editing method for high-efficiency homozygous tagging of endogenous proteins with auxin-inducible degron in human cells, achieving >80% efficiency in A431 cells and >50% in H9 ES cells.

This study shows that RNA deadenylation by the CCR4-NOT complex is critical for suppressing transposable elements in Arabidopsis, independent of small RNA targeting.

This study shows Lactococcus G423 improves broiler growth and survival by altering gut microbiota and metabolites, while antibiotics negatively affect microbiota.

The paper analyzes lineage-restricted shell matrix proteins in two slipper snail species to identify spatial-temporal expression patterns and distinct cell populations in the shell field.

This study shows Bacillus subtilis adapts genetically to different plant hosts and alternating host regimes, revealing both parallel and species-specific evolutionary patterns.

The paper shows that a cancer mutation in METTL14 changes RNA methylation specificity, promoting oncogenesis by altering gene expression without increasing global m6A levels.

This study identifies galectin-3 as a factor that inhibits mitochondrial function and causes cell cycle arrest in CD8+ T cells of severe/critical COVID-19 patients, with potential therapeutic implications.

This study identifies SoSGV as the causative agent of soybean stay-green syndrome and confirms the common brown leafhopper as its vector, revealing its epidemiology and geographical spread.

This study identifies GrgA as essential for Chlamydia's secondary differentiation from reticulate bodies to infectious elementary bodies using a novel gene knockdown strategy.

This study identifies Ophiobolin A's covalent targets in complex IV of mitochondria, revealing a mechanism of metabolic collapse and cell death in cancer cells.

The paper introduces an islet-on-a-chip device (InS-chip) to measure individual islet insulin secretion with high temporal resolution, revealing two glucose-dependent peaks in first-phase secretion linked to metabolic transitions.

This study shows that Mto1 dysfunction disrupts mitochondrial translation, leading to iron overload and defective erythroid differentiation.

The paper identifies an 18-protein signature from proteomic data to stratify intermediate-risk prostate cancer patients into low- and high-risk groups for biochemical recurrence.

This study develops a co-editing strategy to generate transgene-free, gene-edited plants in the T0 generation using Agrobacterium-mediated transient expression of CBE/gRNA and Cas12a/crRNA-GFP.

This study identifies BRD9 as a key regulator of pancreatic cancer stem cell stemness and tumorigenesis, showing that its inhibition reduces CSC self-renewal and enhances chemotherapy response.

This study shows XBB.1.5 has higher ACE2 binding and moderate antibody evasion, contributing to its increased transmissibility compared to other variants.

The paper monitors antibiotic resistance genes in wastewater treatment plants and finds that mass-immigration of bacteria and ARGs from upstream units shapes ARG communities, with stochastic processes dominating their assembly.

The paper identifies a generalized binding pocket for small molecule IKs activators at the extracellular interface of KCNQ1 and KCNE1 channel complexes, explaining their mechanism and guiding future drug design.

This study identifies NuSAP's role in regulating metaphase spindle length by controlling microtubule flux and Kif2A localization during mitosis.

This paper introduces a zero-shot deep learning method for super-resolution microscopy that enhances resolution with less fluorescence and no training data.

This study investigates microRNA-195-3p's role in hypoxia-induced injury of human umbilical vein endothelial cells, finding it upregulated and protective against hypoxia.

This paper describes a novel triptolide analog, CK21, which downregulates the NF-κB pathway and induces mitochondrial apoptosis in human pancreatic cancer cells.

The paper assesses the protective effect of neutralizing antibodies from prior Omicron BA.5 infection against symptomatic reinfection with BA.5, BF.7, CH.1.1, and XBB.1.5 subvariants, finding a strong correlation between antibody titers and reduced reinfection risk.

This study reprograms human fibroblasts into anti-aging neural stem cells using miR-302a, which enhance cognitive function and extend lifespan in mice with Alzheimer's.

This study generates transgene-free canker-resistant citrus plants using Cas12a/crRNA RNP editing, achieving high mutation rates and regulatory approval.

The paper identifies KDM2A as a selective vulnerability in ALT-dependent cancers by showing its role in telomere cluster dissolution through SENP6-mediated SUMO deconjugation.

This study develops anti-seed PNAs targeting oncomiRs 10b and 21 for GBM therapy, showing improved tumor growth inhibition and survival in mice.

The paper measures growth kinetics of HL60 leukemia cell populations under stochastic phenotypic heterogeneity and develops a branching process model to explain observed variations.