Y. Wang

The paper shows that genome editing in the striatum leads to fluorescent reporter expression in the substantia nigra pars reticulata via anterograde axonal transport.

This study identifies co-occurrence of hypermucoviscous and non-hypermucoviscous K. pneumoniae phenotypes in a clonal population, linked to specific mutations and metabolic gene dysregulation.

This paper estimates germline mutation rates across eukaryotes using a phylogenetic meta-analysis of 140 studies, finding higher rates in mammals and plants compared to arthropods and unicellular eukaryotes.

The paper introduces ELAP-seq, a method to detect pseudouridine modifications in RNA with high sensitivity and resolution, identifying over 10,000 sites in human transcripts.

The paper develops a diversified library of nucleoside analogues with enhanced antiviral efficacy and low cytotoxicity, featuring a novel carbobicyclic core structure.

The paper assembles transcriptomes and genomes of alligatorweed to identify gene ontologies linked to invasiveness and provides genomic resources for further studies.

This study characterizes human fetal liver terminal erythropoiesis through RNA sequencing of primary and cultured erythroblasts and immortalized cell lines, revealing gene expression patterns and pathway changes associated with enucleation.

This study shows that the KDELR/Erd2-mediated ER retrieval system regulates UPR and AMPK signaling to maintain cellular homeostasis by affecting mitochondrial respiration and ROS levels.

This study identifies TARBP1 as a driver gene in hepatocellular carcinoma that promotes tumor progression by methylating tRNA and enhancing glutamine metabolism.

This study shows that deleting the Gclc gene in the endocrine pancreas of mice leads to severe diabetes due to oxidative stress and islet dysfunction.

This study shows that ZFP318 regulates mitochondrial function in memory B cells, enhancing their recallability and vaccine potency.

The paper investigates the evolution of a gene regulatory network in amphioxus, showing that enhancer hijacking allowed a new GRN to emerge through the functional shift of Gdf1/3-like to replace Gdf1/3 in axial development.

This study identifies an Il-9-Zbtb18 axis that promotes the development of memory B cells from germinal centers by regulating cell cycle, survival, and GC exit.

This paper reconstructs microbial communities from 2-million-year-old permafrost in Greenland, finding similarities to modern thawing permafrost microbes and suggesting microbial communities may signal climate change impacts before plants and animals.

The paper shows that the potato resistance gene RB uses alternative splicing to balance growth and immunity, with the pathogen effector IPI-O1 promoting splicing to enhance immunity.

This study shows that Hippo signaling modulates chondrocyte responses to mechanical overload by regulating NF-kappaB-mediated inflammation and matrix degradation.

The paper investigates lipid accumulation in foam cells across different diseases and finds that lipid content varies by disease and microenvironment.

This study shows imidacloprid causes developmental delay in honey bee larvae by disrupting molting regulation and nutrient energy metabolism.

This study identifies mutations in the P protein of Avian paramyxovirus type 1 that drive host shift from chickens to pigeons through enhanced degradation of LSm14A.

The paper analyzes single-cell transcriptomes of pig skin from six anatomical regions to characterize cellular heterogeneity and identify candidate genes for ECM accumulation.

This study investigates how linker conformation affects the performance and stability of a two-domain lytic polysaccharide monooxygenase by analyzing wild-type and engineered variants.

This paper identifies Acb2 as a phage-encoded protein that sequesters multiple cyclic dinucleotides and trinucleotides, inhibiting CBASS immunity.

This study identifies Gas1's role in regulating cytosolic proteostasis through the MAGIC pathway and UPS in yeast.

This study examines vinculin's mechanical properties, finding it unfolds and refolds in response to force, suggesting it acts as a mechanotransducer.

This study shows tyramine increases colon cancer risk by causing DNA damage and inflammation in mice.

This study identifies Ferredoxin-1 as the main electron donor to FDP heterooligomers and shows pH-dependent membrane association regulates FDP activity in cyanobacteria.

The paper introduces a genetically encoded mTORC1 inhibition reporter, mTIR, which identifies histone deacetylase inhibitors that selectively target mTORC1 through nutrient-sensing gene expression.

The paper reports the crystal structure of Acinetobacter baumannii TIR domain and its NAD+ hydrolase activity, showing conformational changes and kinetic effects upon substrate binding.

This study shows that FTO, through lactylation-driven m6A modification of CDK2, worsens diabetic retinopathy by promoting angiogenesis and inflammation, and presents a nanotherapeutic approach to inhibit FTO.

The paper uses proteomics to compare DIPG cells in co-culture with brain organoids to control conditions, finding changes in adhesion, DNA synthesis, and dendrite growth pathways.