Y. Yao

The paper predicts conserved T-cell epitopes in SARS-CoV-2 variants using computational methods to identify antigenic peptides that could be used in vaccines.

This paper introduces RPnet, a neural network method for coarse-graining metastable conformational states in protein dynamics, showing comparable or better results than existing methods.

This paper shows that oxidative phosphorylation (OXPHOS) generates most ATP in mouse ESCs and is essential for pluripotency by coupling with the hexosamine biosynthesis pathway to produce UDP-GlcNAc.

This paper introduces LCTC, a method to quantify structural distributions in heterogeneous cryo-EM datasets, showing improved performance over existing methods on simulated and experimental data.

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

This study identifies the SCP4-STK35/PDIK1L phosphatase-kinase complex as a critical signaling dependency in AML, showing its role in proliferation and amino acid metabolism through dual regulatory mechanisms.

This study identifies dipeptides as minimalistic yet sufficient for liquid-liquid phase separation through computational and experimental methods.

This paper develops a microengineered lung organ chip model to study SARS-CoV-2-induced lung injury and immune responses, revealing distinct cellular responses and the role of immune cells in inflammation.

This study determines the atomic structure of PLEKHA7's PH domain and reveals its multivalent interaction mechanism with membrane-bound PIPs, providing insights for inhibitor design.

This paper develops a LAMP-based microfluidic chip for rapid, portable detection of Cryptococcus in CM, enabling visual, sample-to-answer diagnosis without additional instruments.

The study examines the link between Toxoplasma gondii infection and physical education scores in college students, finding higher scores in infected students in specific sports.

This study uses an E. coli model system to investigate the structure and function of Y. pestis Ail in a bacterial cell envelope, revealing its role in virulence and interactions with human serum components.

This paper shows HCMV drives WDR5 to the virion assembly compartment to facilitate virion assembly, expanding its role beyond nuclear egress.

This study identifies therapy-induced transdifferentiation as a mechanism of EGFR-targeted therapy resistance in gliomas, independent of EGFR signaling, and suggests combinatorial therapies targeting both EGFR and transdifferentiation pathways.

The paper introduces a method to label subcellular structures in living specimens using live-cell incompatible dyes under specific conditions, revealing their potential for imaging.

This study shows that polyamine homeostasis in T cells is regulated by de novo synthesis and salvage pathways, affecting proliferation and function, with implications for inflammatory and autoimmune diseases.

The paper shows that KIF5B and KIF13B work together to transport secretory vesicles to microtubule plus ends, with KIF5B playing a dominant role and KIF13B assisting in reaching newly polymerized ends.

This paper identifies a small-molecule inhibitor of influenza A HA stem fusion using a fluorescence polarization screen and validates its antiviral activity against multiple H1N1 and H5N1 strains.

This study investigates the conformational states of full-length Bcl-xL in soluble and membrane-anchored forms using NMR, MD simulations, and ITC to understand its structure and ligand binding.

NAD+ supplementation enhances T cell activation and tumor-killing capacity in immunotherapies.

Doxycycline-inducible dual-color Cas9, purified lentivirus, puromycin-selected nickase HDR, integrase-deficient lentiviral HDR delivery and an all-in-one CRISPRa vector enable editing of macrophage and Jurkat T cells.

MACS is a rapid aqueous clearing method that enables 3D imaging of intact organs with high transparency and compatibility with lipophilic dyes.

The paper identifies that most CD8 T cells in the human small intestine are resident memory cells that persist for over a year and maintain a stable TCR repertoire.

This study shows Lin28B promotes chemoresistance and poor prognosis in HCC, and curcumin reverses this by inhibiting Lin28B.

This paper describes the fusion of DN and AflR genes to create a novel protein that enhances anti-A. flavus activity compared to DN alone.