Y. Zhang

This paper introduces HistoTRUST, a pipeline combining ultraviolet-excited sectioning tomography and deep learning to rapidly generate 3D histological images of whole organs.

This study investigates how IGCR1 regulatory elements and 3'Igh CBEs influence RAG-scanning and V(D)J recombination in progenitor-B cells through chromatin loop extrusion and WAPL down-regulation.

This study functionally characterizes candidate sex determination genes in Salix purpurea using Arabidopsis, supporting ARR17 and GATA15 as master regulators and identifying downstream transcription factors.

This study shows that targeting ACOD1 enhances the pro-inflammatory state and anti-tumor activity of human CAR-iMACs in solid tumors.

The paper reports a high-resolution crystal structure of a mercury-crosslinked ZIP transporter, revealing dynamic motions and a metal relay mechanism for zinc transport.

This study shows that Disulfiram reduces pulmonary fibrosis by reactivating COX-2-mediated PGE2 synthesis in both cell and animal models.

The paper compares mesenchymal-like gene expression programs in neuroblastoma preclinical models and patient tumors using single-cell RNA-seq and identifies chemotherapy-induced changes in PDX and GEMM.

The paper uses CRISPR knockout screens to identify drug combinations that enhance the effectiveness of common chemotherapeutics in neuroblastoma cells.

This study identifies Plexin-B2 as a driver of homotypic and heterotypic CTC clusters in breast cancer metastasis, with high expression linked to poor prognosis and therapeutic potential.

This paper discovers and engineers an L-threonine aldolase from Neptunomonas marine to efficiently synthesize β-hydroxy-α-amino acids with high diastereoselectivity.

The paper introduces a method to label and profile cell-cell interactions with high sensitivity and spatial-temporal resolution using a bioorthogonal photocatalytic quinone methide decaging strategy.

This study identifies ecto-calreticulin as the ligand for the NKp46 receptor, showing it mediates NK cell recognition and killing of ER-stressed cells and tumors.

The paper uses phylogenomic and phylotranscriptomic analyses to study the evolution of nitrogen-fixing root nodule symbiosis across the Nitrogen-Fixing Nodulation Clade, finding no convergence at the amino acid level and highlighting the role of NIN as a master regulator.

This study identifies Vangl2 as a negative regulator of NF-κB signaling in sepsis by promoting autophagic degradation of p65 through NDP52.

The paper identifies acetate as a novel energy stress marker produced in the liver via ACOT12/8-mediated conversion of acetyl-CoA from fatty acids, supporting its role in brain fueling and CoA recycling.

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

This study tracks free radical load in HT-29 colon adenocarcinoma cells during butyrate-induced redifferentiation using fluorescent nanodiamonds as sensors.

This paper introduces a hierarchical strategy using CXMS and AlphaFold2 to analyze protein dynamics in vivo, focusing on IDPs and multi-domain proteins.

The paper identifies widespread stop codon readthrough events in plants and reveals the plasticity of stop codons in encoding amino acids.

This paper introduces Alpha-LFM, a physics-aware deep learning framework for 3D super-resolution imaging of living cells, achieving high resolution, speed, and low phototoxicity over long periods.

This paper develops MUCIG, a CRISPR-Cas13d-based method to silence multiple immunosuppressive genes in the tumor microenvironment, showing efficacy in preclinical models.

This study identifies genetic factors limiting NK cell function in tumors using CRISPR screens and single-cell sequencing, highlighting CALHM2 as a target for improving NK cell-based therapies.

The paper introduces a composite gene delivery system called MAJESTIC for efficient and stable engineering of therapeutic immune cells, showing improved cell viability and transgene expression compared to existing methods.

This paper introduces a single-shot 3D photoacoustic tomography method using a single-element detector to enable ultrafast hemodynamics imaging in humans and small animals.

The paper identifies ADA as a metabolic regulator that enhances CAR-T cell function and tumor clearance through improved metabolism and reduced exhaustion.

This study characterizes urine proteomic changes in active and recovered COVID-19 patients, identifying persistent immune and metabolic alterations and potential biomarkers.

This paper introduces a Bayesian topic model to analyze single-cell RNA-seq data and identifies dynamic gene programs in pancreatic cancer associated with prognosis and immune pathways.

The paper shows degenerated CRISPRs encode regulatory RNAs that autoregulate Cas protein expression, balancing immunity and host fitness costs.

The paper shows that evolution in Pseudomonas aeruginosa populations selects for cheater mutants that modify social cooperation to stabilize chronic infections and reduce host immune response.

This study reports cryo-EM structures of zebrafish P2X4 receptors bound to antagonists, revealing ligand-dependent structural changes that explain subtype-specific allosteric inhibition.