Y. Zhang

This study identifies MIZ1-TMBIM4 as a mechanism safeguarding IgG1+ GC B cell positive selection by regulating Ca2+ mobilization and preventing mitochondrial dysfunction.

This study shows that gene supplementation for LMNA cardiomyopathy is ineffective when targeting cardiomyocytes alone, as non-cell autonomous effects dominate, suggesting alternative therapeutic targets.

The paper constructs a super-pangenome of 19 Populus species to explore genomic factors driving adaptation and diversification in forest trees.

The paper reports cryo-EM structures of the Schizosaccharomyces pombe Clr6S complex, revealing its active site and interactions with a nucleosome.

This study identifies S100A11's role in promoting focal adhesion disassembly through myosin II-driven contractility and Piezo1-mediated Ca2+ entry.

This paper develops a 3D microtumour system that mimics ovarian cancer minimal residual disease, showing it responds to chemotherapy and reflects molecular signatures of MRD.

This study identifies HSPB1 as a driver of chemoresistance in breast cancer by inhibiting ferroptosis and activating NF-κB signaling.

This study identifies NS2's SUMO-interacting motif as critical for avian influenza virus adaptation to mammals by enhancing vRNP assembly and ANP32A/B interactions.

This study identifies plasma metabolic signatures in sickle cell disease patients linked to cardiorenal dysfunction and treatment response.

This study compares gene expression between primary and brain metastatic breast cancer cells, identifying differences in pathways and cell states that contribute to metastasis.

This paper introduces circDesign, an algorithm for designing synthetic circular RNA that improves stability and protein translation efficiency, demonstrated using rabies virus glycoprotein.

The paper identifies Vps13-mediated lipid transfer at ER-endosome contact sites as essential for ESCRT-mediated sorting during MVB formation.

The paper introduces aSRRF, a method that enhances SIM resolution to ~50 nm isotropically using image augmentation without changing the optical setup or sample acquisition.

The paper determines the cryo-EM structure of mouse TMEM63C, reveals structural differences from plant orthologues, and shows TMEM63C functions as a monomer while TMEM63B is a mix of monomer and dimer.

This study introduces disulfides into SARS-CoV-1 spike protein to stabilize locked conformations, revealing conserved structural features with SARS-CoV-2.

The paper designs an antimicrobial peptide based on the structure of C. difficile translation initiation factor 1, showing strong antibacterial activity against C. difficile and other bacteria.

The study finds that larval thermal tolerance of Orbicella faveolata does not match the thermal tolerance of their adult source populations, challenging the assumption that tolerant parents produce tolerant offspring.

This study identifies that clonally diverse CXCR5+ B cells enhance IFNγ pathway activity and CD8 T cell responses, leading to durable ICI therapy outcomes in melanoma.

This paper shows recombinant outer membrane vesicles with cytokines enhance immune responses and H. pylori clearance in mice compared to traditional adjuvants.

This study compares 3D and 2D culture of Cx43-deficient OCY454 osteocytes, finding that 3D cultures enhance differentiation and bone remodeling factor secretion, while Cx43 deficiency increases signaling to promote osteoblast and osteoclast formation.

This paper deletes the I196L gene from ASFV SY18, resulting in a less virulent recombinant virus that protects pigs against ASFV challenge.

This study identifies CDK6 as a regulator of axoneme polyglutamylation by phosphorylating FIP5, leading to impaired cilia function and ciliopathies, and shows CDK6 inhibitors can restore cilia function.

The paper discovers and characterizes two lasso peptides from Achromobacter species, showing one inhibits RNA polymerase and has antimicrobial activity against Achromobacter pulmonis.

This paper identifies Levy statistics as a marker for anxiety and depression in mice under chronic stress, using movement patterns and machine learning for classification.

The paper develops a diversified library of nucleoside analogues with enhanced antiviral efficacy and low cytotoxicity, featuring a novel carbobicyclic core structure.

This study identifies TARBP1 as a driver gene in hepatocellular carcinoma that promotes tumor progression by methylating tRNA and enhancing glutamine metabolism.

This study identifies NOP16 as a histone mimic that regulates H3K27 methylation and gene repression, showing its role in breast cancer progression.

This study identifies dynamic transcriptional changes during the dimorphic transition of Talaromyces marneffei using a novel model, DyGAM-NS, and reveals asymmetrical gene expression patterns and regulatory networks.

The paper investigates how linker length affects phase separation in the Rubisco-EPYC1 system of green algae, finding that shorter linkers significantly reduce critical concentrations.

This study identifies Gpr35 as a regulator of a gut-brain metabolic axis that influences depressive-like behavior in mice, highlighting microbial metabolites as potential therapeutic targets.