Y. Zhao

This study engineers docking domains in modular PKSs to couple polypeptides, showing that high-affinity interactions can improve synthesis but may reduce rates, with efficiency recovery through hinge regions.

This paper develops FUS-CRISPR(a/i) tools to remotely control gene expression and epigenetic modifications in vivo, showing therapeutic effects in tumor models.

This study shows that domestication in barley extends the apical meristematic phase for node initiation but restricts internode elongation, with genetic factors influencing these processes along latitudinal and longitudinal gradients.

The paper determines the cryo-EM structure of the human ULK1C core and its complex with PI3KC3-C1, revealing structural changes that suggest a mechanism for autophagy initiation through supercomplex formation.

This study investigates how Nde1 and Lis1 regulate dynein complex assembly and motility using in vitro reconstitution and single molecule imaging, revealing two distinct roles for Nde1 in promoting dynein activation.

The paper analyzes the relationship between diterpene synthase sequences, structures, and their products to identify functional residues that influence product specificity.

This study investigates the relationship between cardiac conduction velocity and extracellular space structure, finding a biphasic relationship with perinexal separation, supporting ephaptic coupling over gap junction-based conduction.

This paper establishes a hairy root culture and genetic transformation system in Stephania tetrandra to enhance bisbenzylisoquinoline alkaloid production.

The paper identifies cellular and molecular signatures associated with varying severities of West Nile Virus infection using multi-omics analysis of immune responses.

This study uses single-cell multi-omics to map epigenetic and transcriptomic changes in retinoblastoma, identifying key regulators and potential drug targets.

The paper identifies that subterranean mammals have abundant high-molecular-mass HA due to genetic changes, which may aid in cancer resistance and adaptation to hypoxic environments.

This study investigates DNA repair mechanisms in bowhead whales, showing their high efficiency and accuracy in repairing DNA damage, which may explain their long lifespan without cancer.

This paper develops Au-CS@FNDs contact lens additives to block UV, prevent bacterial keratitis, and inhibit corneal neovascularization.

This study identifies Sox11 as a marker of differentiating muscle satellite cells, showing reduced expression in quiescent and aged cells, but finds it dispensable for muscle development and regeneration.

This paper uses two transgenic mouse models to study APOL1 risk variants' effects on glomerular disease, identifying shared and distinct transcriptional changes in podocytes.

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

The paper identifies auto-antibodies secreted by plasma cells in PDAC against self-antigens, suggesting a link between chronic inflammation and autoimmunity.

The paper identifies widespread stop codon readthrough events in plants and reveals the plasticity of stop codons in encoding amino acids.

This study shows that LIFR in hepatocytes regulates neutrophil recruitment and activity to promote liver regeneration through CXCL1-CXCR2 and cholesterol-HGF pathways.

This study identifies ZmPTOX1 as a key gene for carotenoid biosynthesis in maize kernels, showing that its disruption reduces carotenoid content while overexpression increases it, particularly beta-carotene.

This study reports cryo-EM structures of zebrafish P2X4 receptors bound to antagonists, revealing ligand-dependent structural changes that explain subtype-specific allosteric inhibition.

The paper develops an OM proximity labeling system to map the proteome of cytosol-facing outer membranes in Arabidopsis cells and identifies potential receptors for protein translocation and organelle communication.

This study shows that excessive apoptosis in naïve T cells causes hyperactivation and accelerates aging in mice, suggesting T-cell changes are a cause of aging.

The paper develops a high-throughput platform for screening functional neo-antigens and their specific TCRs using droplet microfluidics and DNA barcoding.

This study shows that SOX17 deficiency in endothelial cells causes pulmonary hypertension via E2F1 signaling, suggesting E2F1 as a therapeutic target in PAH.

This study reveals that neutrophils, not macrophages, primarily clear apoptotic hepatocytes through a novel process called perforocytosis, and defects in this process contribute to autoimmune liver disease.

This study identifies lipids as the primary contributors to NOE(-3.5 ppm) signals in brain tissues and shows their role in MRI contrast variations between tumor, gray matter, and white matter.

This study shows HIV Vpr reduces DCT1-type renal tubules in mice, leading to salt wasting via apoptosis dysregulation of Slc12a3+ Pvalb+ cells.