Y. Zhou

The paper develops a cross-nearest neighbor/Monte Carlo algorithm to analyze interactions between p53, Mdm2, and MEG3 using single-molecule localization microscopy in U2OS cells.

This study identifies BolA as a key virulence factor in Klebsiella pneumoniae that enhances stress resistance, cell adhesion, siderophore production, and virulence in animal models.

This paper develops a mini-replicon-based reverse-genetics system for RSV, enabling functional analysis of its genes and host interactions in Nicotiana benthamiana.

This paper introduces BISECT, a method that accelerates cryo-electron tomography data acquisition and improves resolution by using beam-image shift and advanced processing techniques.

The paper designs SARS-CoV-2 neutralizing antibodies using a computational platform to improve binding affinity and developability, and introduces trispecific formats and Fc modifications to enhance efficacy and reduce risk.

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

This study shows that REGEN-COV, a combination of non-competing antibodies, provides broad coverage against SARS-CoV-2 variants and prevents the emergence of new variants in clinical and preclinical settings.

This study develops AIM-CICs, an AI-based method using CNN to automatically identify and classify cell-in-cell structures, improving efficiency and accuracy over manual methods.

This study identifies DARPP-32 as a mediator of ERBB3-driven resistance to EGFR TKIs in lung adenocarcinoma, showing its role in promoting oncogenic signaling and tumor progression.

This study identifies introgressed regions in North American wild grapes, showing their association with adaptive traits and environmental pressures.

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.

The paper classifies neoantigens based on immune interactions and improves their prioritization for cancer immunotherapy.

This study shows that LXRβ suppresses hepatic stellate cell activation via inhibition of Hedgehog signaling, offering a potential therapeutic target for liver fibrosis without causing liver steatosis.

The paper analyzes weight loss outcomes in response to a lifestyle intervention and identifies baseline gut metagenomic features associated with weight loss in humans.

This study identifies FDA-approved drugs that inhibit urease activity in H. pylori, offering potential new treatments for infections.

This study identifies CHI3L1 as a key mediator of aging-related severity in COVID-19 by stimulating ACE2 and SPP expression, and shows it is a therapeutic target.

This study analyzes H7N9 virus genome mutations in human clinical samples to identify potential adaptations during infection.

This study identifies ALC1 as a key determinant of PARPi toxicity in HR-deficient cells by linking PARP-dependent chromatin remodeling to PARPi response.

The paper shows that bone marrow adipocyte whitening during obesity drives the increase of invasive Ly6Chigh monocytes, preceding adipose tissue macrophage expansion.

The paper shows wild-type sTREM2 inhibits Aβ aggregation and neurotoxicity, while the R47H variant promotes Aβ aggregation and neurotoxicity.

This study evaluates the efficacy of HCV protease inhibitors against SARS-CoV-2 and their interactions with remdesivir, finding simeprevir shows synergism and is the most promising for future antiviral treatments.

This study examines sex differences in MRI and MRE metrics related to glioma invasion and brain mechanics, finding sex-dependent relationships between tumor stiffness and growth parameters.

This study analyzes fecal microbiota composition in CRC patients and identifies Fusobacterium as a potential biomarker for CRC screening in Chinese populations.

This study identifies SMYD5 as a driver of IBD by downregulating mitochondrial functions through methylation-dependent degradation of PGC-1α in intestinal epithelial cells.

This study introduces a fast lysine cross-linker DOPA for mass spectrometry analyses, showing it enables rapid protein cross-linking and captures dynamic conformational changes and weak protein-protein interactions.

This study shows SATB2 drives melanoma invasion and drug resistance by inducing a neural crest mesenchyme-like transcriptional program in zebrafish and human models.

This paper identifies how GCRV proteins interact with fish RLR factors to suppress MAVS-TBK1 signaling and reduce IFN expression, revealing a unique fish virus evasion mechanism.

This study shows that combining gemcitabine/cisplatin with CDK4/6 inhibitors improves efficacy and reduces toxicity in biliary tract cancers through mechanisms involving autophagy and RRM1 reduction.

This study uses single-cell RNA sequencing to identify silkworm hemocyte subsets and analyze their response to BmNPV infection, revealing diverse gene expression changes and immune suppression.