Y. Zhou

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

This study uses carbon dots to visualize adult bone growth, injury, and regeneration in zebrafish, showing their selective deposition and non-interfering properties.

CancerVar scores and classifies somatic mutations into four tiers using a rule-based system and a deep learning model, improving interpretation of both known and novel mutations in cancer.

This study evaluates the in vitro antiviral efficacy of Artemisia annua extracts and artemisinin derivatives against SARS-CoV-2, finding artesunate to be the most potent.

The paper investigates the genomic basis of symbiosis in a vent snail, revealing a tripartite holobiont system involving host, endosymbionts, and gut microbiota, highlighting metabolic flexibility and mutualistic interactions.

The paper introduces a method to measure single-cell cytoskeletal protein complex expression heterogeneity and finds some cells upregulate other cytoskeletal complexes in response to stress.

This study shows TRPC5 inhibition protects human podocytes from injury in vitro and in vivo, supporting its therapeutic potential for kidney diseases.

This study classifies bladder cancer patients into immune and non-immune groups using NMF and NTP algorithms, finding immune-activated patients respond better to anti-PD-1 therapy.

The paper analyzes SARS-CoV-2 quasispecies structure using SMRT sequencing, revealing a One-King model with dominant and minor haplotypes and their evolutionary dynamics.

The paper determines the structure of a type IV-B CRISPR-Cas effector complex using cryo-EM, revealing its unique assembly and function.

The paper uses single-cell RNA sequencing to identify early transcriptional changes in kidney cells after podocyte injury, revealing disrupted cell-cell interactions that contribute to chronic kidney disease progression.

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

The paper reports the crystal structure of PbSRD5A and provides biochemical insights into the conserved mechanism of steroid 5-reductase catalysis.

The paper identifies 9240 lncRNAs in diploid cotton using multi-omics data and reveals their transcriptional regulation and co-expression with protein-coding genes and GWAS SNPs.

The paper identifies Fab-dimerized glycan-reactive antibodies in HIV-infected macaques and HIV-naïve humans that neutralize HIV-1 and can be elicited by vaccination.

This study shows the SARS-CoV-2 envelope protein causes ARDS-like damage and identifies channel inhibitors as potential antiviral targets.

The paper introduces Metaboverse, a tool for network-aware reaction pattern recognition in metabolic data, identifying regulatory signatures of mitochondrial dysfunction in lung adenocarcinoma and respiratory deficiency models.

This study uses high-density amplicon sequencing to show ongoing SARS-CoV-2 evolution and community spread in a Southern U.S. suburban area, identifying the D614G variant as dominant.

The paper identifies 5.9% of Type I R-M systems with duplicated hsdS genes that enable phase-variation through recombination, found in pathogens like Enterococcus faecalis and Listeria monocytogenes.

This study identifies Wee1 as a therapeutic target in combination with avapritinib for treating gastrointestinal stromal tumors (GIST) by analyzing kinome profiles and conducting functional assays.

This study identifies Netrin G1 as a promoter of pancreatic ductal adenocarcinoma tumorigenesis by enhancing cancer-associated fibroblast-driven metabolic support and immunosuppression.

This study identifies an immune class in prostate cancer associated with better recurrence-free survival and response to anti-PD-1/PD-L1 immunotherapy.

This study shows that immunization with SARS-CoV-2 RBD induces antibodies that neutralize both SARS-CoV-2 and SARS-CoV without causing antibody-dependent enhancement.

The paper describes electron microscopy of KHV GY01 infected cells and whole genome analysis to study its characteristics and phylogenetic relationships with other KHV strains.

The paper shows that hyperbolic metrics better describe odorant mixtures from Brassica rapa than linear metrics, improving predictions of pollinator resource preferences.

This study identifies PDE6D as a potential target of sorafenib using PROTAC technology and proteomic analysis.

This study develops a vaccine candidate against SARS-CoV-2 using virus-like particles displaying the receptor binding domain, which induces neutralizing antibodies in mice.

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

This study shows that protoporphyrin IX and verteporfin inhibit SARS-CoV-2 infection in vitro and in a human ACE2-expressing mouse model by blocking ACE2-S protein interaction.

This paper introduces DraBot, a dragonfly-inspired soft robot capable of locomotion, sensing, and environmental adaptation using pneumatic and microfluidic logic.