Andrea Baccarelli

Epigenome-wide association study meta-analysis of wellbeing

This study conducts an epigenome-wide association study (EWAS) meta-analysis of wellbeing using DNA methylation data, finding no significant methylation sites but suggesting the need for larger studies.

CoxMDS: Multiple Data Splitting for High-dimensional Mediation Analysis with Survival Outcomes in Epigenome-wide Studies

CoxMDS identifies causal mediators in DNA methylation studies with survival outcomes, maintaining FDR control and higher power than existing methods.

Environment-wide and epigenome-wide association study of adiposity in "Children of 1997" birth cohort

This study identifies modifiable factors and epigenetic markers associated with adiposity in adolescents from Hong Kong using EWAS and EWAS.

Deciphering causal proteins in Alzheimer's disease: A novel Mendelian randomization method integrated with AlphaFold3 for 3D structure prediction

The paper develops MR-SPI, a Mendelian randomization method integrated with AlphaFold3 to identify causal protein biomarkers and predict 3D structural changes in Alzheimer's disease.

Epigenome-wide meta-analysis of BMI in nine population-based cohorts: examining the utility of methylation as a biomarker of BMI

This study identifies CpG sites associated with BMI and shows that epigenetic BMI prediction correlates with metabolic health markers.

An integrative analysis of clinical and epigenetic biomarkers of mortality

The paper integrates DNA methylation with clinical risk factors to improve mortality prediction, identifying CpG biomarkers associated with all-cause, cardiovascular, and cancer mortality.

Large-Scale Hypothesis Testing for Causal Mediation Effects with Applications in Genome-wide Epigenetic Studies

The paper develops a new statistical test, DACT, to detect mediation effects in genome-wide epigenetic studies and applies it to identify DNA methylation sites mediating smoking's effect on lung function.

Methylome-Wide Association Study Of Central Adiposity Implicates Genes Involved In Immune And Endocrine Systems

This study identifies DNA methylation sites associated with central adiposity traits in adults and adolescents using methylome-wide association analyses across multiple cohorts.

Quantification of the pace of biological aging in humans through a blood test: The DunedinPoAm DNA methylation algorithm

The paper develops a DNA methylation-based blood test, DunedinPoAm, to quantify individual differences in the pace of biological aging and validates its association with aging-related outcomes across multiple studies.

Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

This study identifies nine novel DNA methylation sites associated with fasting glucose and insulin levels by integrating cross-omics data from multiple cohorts.

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

This study identifies genetic variants associated with epigenetic age acceleration and shows TERT's role in regulating the DNA methylation clock.