Sean Lal

Long-read sequencing-based atlas of tissue-specific expression of Drp1 transcript variants

The paper uses long-read sequencing to map Drp1 transcript variants in human and mouse tissues, revealing tissue-specific expression and isoform-dependent mitochondrial fission activity.

DNA Methylation Ageing Atlas Across 17 Human Tissues

The paper creates a DNA methylation aging atlas across 17 human tissues, identifying conserved and tissue-specific aging signatures and potential therapeutic targets.

Maturation of human cardiac organoids are required for disease modelling and drug discovery

This study shows that maturing human cardiac organoids enhances disease modeling and drug discovery by mimicking in vivo development and enabling therapeutic testing for DSP cardiomyopathy.

Single-cell transcriptional and epigenetic mapping reveals cellular and molecular mechanisms driving non-ischemic cardiac fibrosis

This study uses single-cell multiomic analysis to identify transcriptional circuits driving non-ischemic cardiac fibrosis in mouse and human hearts, showing reversibility of fibrosis-related changes.