Stephan P. Rosshart

The microbiome determines the phenotype in CTLA-4 insufficient mice and men

This study shows that the microbiome influences disease severity in CTLA-4 insufficient mice and humans by altering immune responses and promoting inflammation.

A neuroimmune IL-13 axis is associated with human enteric nervous system development

This study identifies a neuroimmune IL-13 axis involved in human enteric nervous system development through transcriptomic and functional analyses of neonatal ileum tissue.

Natural microbial exposure imposes layered constraints on epithelial and type 2 immunity

The study shows that natural microbial exposure reduces tuft cell responsiveness in mice, affecting type 2 immunity and helminth resistance compared to sterile conditions.

Postnatal Maturation of Dendritic Epidermal T Cells and Langerhans Cells Follows Distinct Differentiation Trajectories Independent of Microbiota

This study maps the postnatal differentiation trajectories of dendritic epidermal T cells and Langerhans cells in mice, showing they develop independently of each other and microbial colonization.

Neonatal liver niches program T cell tolerance

The paper identifies a neonatal liver program that expands regulatory T cells while limiting conventional T cell activation, influencing susceptibility to viral infections and protection against liver disease.