genetic perturbation / CRISPR

The paper shows that glutamate and neuropeptide signaling in C. elegans males convert brief mate contact into a persistent search behavior.

This study shows KAT6 and KAT7 maintain mitotic chromatin acetylation and composition, supporting postmitotic transcriptional memory and developmental competence in stem cells.

The paper identifies SEC16A/MAG5 as essential for ABA receptor homeostasis by mediating ER export and trafficking, impacting ABA signaling without affecting ABA levels.

This study identifies fss genes that regulate stalked cell morphogenesis and cell cycle progression independently of the flagellum in Caulobacter crescentus.

This study identifies ferroptosis in embryonic lung and kidney progenitor cells, showing its role in organ morphogenesis through genetic manipulation of Gpx4.

The paper shows serotonin signaling spatially controls nutrient-responsive midgut turnover in Drosophila by regulating enteroblast maturation and morphological changes through the 5HT7 receptor.

This study identifies an mTORC1-PWP1-Hedgehog circuit that links nutrient metabolism to intestinal stem cell differentiation in Drosophila, showing its role in aging and tissue renewal.

The paper identifies SamI as a cytosolic SPFH protein that couples membrane stress to differentiation in Bacillus subtilis by stabilizing a membrane complex involved in stress signaling and biofilm formation.

This study identifies CCNB1IP1 as a regulator of neocortex size and folding in primates, showing its expression increased alongside brain evolution.

This study shows that loss of type I restriction-modification methyltransferases in Pseudomonas aeruginosa increases fluoroquinolone persistence through enhanced SOS response and slower growth.

This study shows PDLIM2 suppresses lung adenocarcinoma metastasis by reducing pro-tumor inflammation and enhancing anti-tumor immunity in human and mouse models.

This paper identifies SepIVA as a divisome activator in M. smegmatis, showing it is inhibited during DNA damage by disrupting its interaction with FtsQ.

This study investigates the genomic consequences of repeated loss of distyly in Linum species, finding mixed evidence for relaxed selection and no clear genomic signature of selfing in homostylous lineages.

The paper shows that CRISPR-mediated herd immunity in E. coli promotes frequent homologous recombination by maintaining genetic diversity and enabling gene flow, enhancing adaptation rates.

This study identifies RICTOR as a regulator of dietary plasticity in C. elegans, showing it modulates longevity through a methionine cycle-mitophagy axis influenced by bacterial vitamin B12.

The paper investigates how Pseudomonas aeruginosa aggregates respond to host-derived stress, identifying a role for potassium homeostasis in aggregate stability and dispersal.

The paper identifies MIKC MADS-box transcription factors ABS/TT16 and STK as regulators of maternal nutrient flow during ovule maturation and seed development in Arabidopsis.

This study shows that the Drosophila gene short stop has opposing roles in dendrite stability and regeneration, with distinct effects on DLK and JNK signaling in different neuron types.

The paper compares the role of Stu2 and Ipl1 in error correction during meiosis and mitosis in budding yeast, finding that Stu2 is more critical for accurate chromosome segregation in meiosis.

This study identifies TFB2, a TFIIB paralog, as a key regulator of cyclic transcription in Sulfolobus acidocaldarius, linking it to cell cycle progression without CDKs.

Rag1-knockout newts lacking adaptive immunity regenerate larval limbs, tails and adult limbs without overt gross differences from controls; newt blastema tolerates allografts, and axolotl regenerating limbs show immunosuppressive transcriptional shifts.

This study shows that YAP and TAZ redundantly regulate muscle regeneration by controlling proliferation and migration of muscle stem cells, revealing genetic redundancy as essential for regenerative robustness.

This study shows UPR signaling promotes myeloid cell production and collaborates with Jak2V617F mutation to exacerbate disease in polycythemia vera.

This study shows that heat shock activates HLH-30/TFEB independently of mTORC1 and AMPK, revealing stress-specific regulation of this transcription factor.

This study shows that IF1 limits mitochondrial membrane potential elevation and prevents epithelial-mesenchymal transition in human iPSCs by inhibiting ATP hydrolysis.

The paper identifies Tom70 as a regulator of nuclear pore complex exclusion during gametogenesis in yeast by mediating mitochondria-nuclear envelope contacts.

This study shows brassinosteroids enhance sugar synthesis by inhibiting BIN2 phosphorylation of PCK, promoting gluconeogenesis and photosynthesis in plants.

This paper identifies three atypical PI3Ks in Dictyostelium that regulate distinct aspects of chemotaxis, signaling, and multicellular development.

The paper discovers a new family of giant viruses, Mycodnaviridae, that infect zoosporic fungi and persistently infect them, expanding the known host range of Nucleocytoviricota.

This paper identifies a small RNA-driven morphogenic circuit in maize embryos that regulates shoot stem cell specification through auxin signaling and cell division patterning.