mechanistic / dynamical model

This paper develops a mechanistic framework linking within-host pathogen dynamics to vector-mediated transmission under climate forcing, showing temperature affects epidemic spread through changes in host infectiousness duration.

This study characterizes the ribosomal exit tunnel's functional complexity across species using molecular dynamics simulations, revealing dynamic changes and lineage-specific features.

The paper analyzes conditions for the emergence of adaptive polymorphism under long-term evolution, identifying negative trait-dependent selection as a unifying mechanism across ecological, social, and genetic interactions.

This study investigates how chromatin compaction affects retroviral integration by analyzing the interaction between intasomes and nucleosomes, revealing distinct strategies in HIV-1 and PFV.

This study quantifies age-related changes in the mechanical properties of mouse oocyte spindles using a combination of coarse-grained modeling and in situ experiments.

This study investigates how core fucosylation affects IgG1-FcCD16a binding through molecular dynamics simulations, revealing structural and dynamic changes that reduce ADCC.

This study identifies a non-catalytic role for Rad18 in sustaining glioblastoma proliferation and proposes it as a therapeutic target.

This study identifies ATP13A3-antizyme regulation as a mechanism for adaptive polyamine uptake in cancer, showing that targeting ATP13A3 with AMXT 1501 can block this response.

This study uses molecular dynamics simulations to analyze the conformational ensembles of the hairpin ribozyme's active site along competing catalytic pathways, finding that monoanionic pathways are more favorable than a dianionic mechanism.

This study compares structural variations in BRCA1/BARD1 orthologs across species to show how a structural loop affects ubiquitylation site selection and chromatin regulation.

This study shows that prolonged crowding induces an invasive phenotype in cancer cells through mechanomemory, mediated by membrane domain disaggregation under compressive stress.

This paper identifies putative glucose transporters in Trichuris spp and shows phloretin may inhibit glucose uptake, suggesting a new target for anthelminthic drug discovery.

This study develops coarse-grained models to show how nucleosome spacing and ATP-dependent remodeling influence chromatin condensate structure, dynamics, and organization.

This study shows that altering charge on bacterial microcompartment shell proteins can control their self-assembly into tubular structures.

This study identifies co-targeting of MCL-1 and ETC complex I as a synergistic therapy for high-risk AML, showing improved viability reduction and survival in preclinical models.

This study shows that bispecific antibody architecture and TNFRSF target selection influence CD8+ T cell differentiation and anti-tumour immunity, with 4-1BB being the most effective target.

This study shows seipin undergoes conformational changes at the ER-LD interface, enabling lipid droplet growth and regulated lipid storage.

This paper develops a mathematical model of virus-host interactions during RNA virus infection, revealing how immune dynamics and viral strategies determine infection outcomes.

This paper identifies protein-glass microenvironments in Complex I that correlate with electron transfer vulnerability in Leigh syndrome mutations.

This paper uses molecular dynamics simulations to show how different antimicrobial peptides alter membrane mechanical properties in a dose-dependent manner, with structured peptides causing greater softening than disordered ones.

The paper introduces a 3D viscoelastic cell-network model that links single-cell interactions to tissue rheology, validated against experimental assays.

The paper develops a mathematical model to study how phenotypic plasticity and competition between HER2+ and HER2- cells affect treatment outcomes in breast cancer, showing that treatment order and intensity influence long-term tumour composition.

This study evaluates three ergosterol-derived compounds as inhibitors of key enzymes in Bothrops asper venom, showing dose-dependent inhibition of coagulant and phospholipase A2 activities.

This paper uses mathematical modeling to show that avian demographic traits like breeding timing and offspring production significantly influence West Nile virus transmission dynamics in Lombardy, Italy.

This study identifies FAN and FIP1 as ribosome biogenesis factors in Arabidopsis, showing their role in BR signaling and heat tolerance through pre-rRNA processing and translation efficiency of BRI1.

This paper develops and validates a multiscale Hill-type neuromuscular actuator against experimental benchmarks of motor unit and muscle force measurements, showing improved accuracy in force reproduction.

The paper identifies a histidine switch that regulates pH-responsive self-assembly of a helical protein filament through electrostatic interactions.

The paper determines cryo-EM structures of Class Ib RNR catalytic α-subunit in apo and holo states, revealing asymmetric nucleotide binding and conformational dynamics that drive half-site reactivity.

This study identifies DC-SIGN as a mechanosuppressive checkpoint that drives tumor immune evasion and resistance to PD-1 blockade by suppressing T-cell function through ICAM-2-ERM signaling.