development & morphogenesis

The paper maps gene expression, chromatin accessibility, and DNA methylation in developing human brain cells to understand regulatory interactions and their role in disease.

The paper identifies a conserved profibrotic transitional state arising from alveolar and airway progenitors in fibrosis and shows its epigenetic regulation.

This study investigates brain-body interactions during food anticipation using multimodal physiological recordings, finding distinct changes in gastric and cortical responses linked to appetite and craving.

This study shows KAT6 and KAT7 maintain mitotic chromatin acetylation and composition, supporting postmitotic transcriptional memory and developmental competence in stem cells.

This study shows that older adults exhibit enhanced implicit motor adaptation only with consistent errors, not variable ones, suggesting error consistency is key for age-related adaptation.

The paper examines lifespan changes in neural temporal dynamics using resting-state MEG data, finding distinct trajectories for cortical intrinsic timescales and alpha oscillations.

This paper introduces active eye modeling to estimate retinal image quality across the visual field during everyday activities, finding that near work under dim lighting increases peripheral blur.

This study examines sex differences in muscle volume, strength, and motor unit properties during bed rest and retraining in young males and females, finding no sex differences in strength loss but greater MU firing rate reduction in females.

The paper investigates whether traveling waves in attention networks reflect top-down attention signals or are a byproduct of sustained attention, finding they align with the intrinsic rhythms of engaged sensory systems.

This study identifies prenatal adversity and neonatal brain connectivity as predictors of infant sensory over-responsivity, which links to later behavioral problems.

This study generates human lymphatic organoids from pluripotent stem cells using two mesodermal routes, showing they form functional vascular networks and support immune interactions.

The paper identifies a rare population of neural crest-derived endocardial cells essential for heart valve development in mice and humans, showing their role in valve morphogenesis through Pthlh signaling.

The paper identifies CD90 as a marker distinguishing two muscle stem cell subpopulations with different activation kinetics and quiescence maintenance mechanisms in mice and humans.

This study shows that TLR7 in lung epithelial cells drives RSV and influenza replication and disease, but not HPIV3, and links TLR7 expression to sex differences in viral disease.

This study compares somitogenesis across human, pig, sheep, and cow stem cell-derived embryo models, revealing species-specific WNT signaling and extracellular matrix requirements for axial segmentation.

This paper introduces a microfluidic platform for applying multiaxial mechanical loading to cell-laden scaffolds, demonstrating its ability to promote cardiac tissue organization and contractile activity.

This study shows that implicit recalibration becomes flexible after prolonged training on novel sensorimotor mappings, allowing context-specific adaptation.

This study investigates metabolic complexity in the human brain using PET and fMRI, finding that metabolic entropy correlates with network metastability and declines with age.

This study shows that cGAS integrates TLR signaling in platelets to drive thromboinflammation by sensing mitochondrial DNA.

The paper examines how cortical bursts influence phase synchrony development in preterm infants and links persistent phase-based connectivity to poorer neurocognitive outcomes.

This study compares cortical interneuron migration across species, finding that human interneurons migrate slower and more dispersedly due to CCP1-dependent changes in microtubule dynamics.

The paper presents a multimodal dataset from a 40-hour forced-desynchrony protocol to study circadian rhythms and their effects on physiology, ocular function, and behavior.

This study examines how pubertal timing affects adolescent brain vulnerability by analyzing brain hierarchy changes before and after the pandemic.

This study identifies the pituitary as a conserved regulator of regeneration across vertebrates, showing its role in limb and fin regeneration through prolactin and growth hormone signaling.

This study shows that sharks and rays have cartilage canals in their adult skeletons, which are vascular but do not trigger endochondral bone formation, suggesting an ancient role in nutrient transport.

This paper shows that adjusting Activin A levels in a 3D bioreactor system can generate liver-like structures from human stem cells, mimicking early liver development.

This study shows that cytoplasmic recapping of MALAT1 produces the micropeptide MARS, which is regulated by RNA G-quadruplex structures and involved in oxidative stress response.

The paper investigates nuclear wrinkles in epithelial cells, finding they form due to geometric adaptations to mechanical stress and cell shape changes, without causing damage.

This study identifies sex-biased mechanisms of immune aging in males, showing lymph node contraction reduces naive CD8 T cell availability and compromises cancer antigen recognition, with potential therapeutic interventions.