Autism Spectrum Disorder Research

The paper identifies 1,189 commonly perturbed genes in ASD blood transcriptomes using personalized perturbation profiles and links them to cellular processes like DNA damage and autophagy.

This study shows that stress-induced PTSD-like memory worsens ASD traits in mice through hyperactivation of the prefrontal cortex and parvalbumin interneuron dysfunction, and suggests recontextualization as a potential treatment.

This study uses light-sheet microscopy to analyze embryonic Chd8+/- mouse brains and finds decreased lateral ventricular sphericity and increased intraocular distance.

This study examines brain structural correlates of autistic traits in a mixed sample of adults with and without clinical autism diagnoses, finding grey matter and white matter microstructure differences associated with higher autistic traits.

This study investigates the heterogeneity in ASD by analyzing transcriptome data to identify differently expressed genes and explore how heterogeneity affects molecular signals.

The paper investigates the relationship between temporal resolution and sensory hyperreactivity in ASD, finding no direct link between temporal resolution and stimulus detection sensitivity.

This study identifies higher functional network idiosyncrasy in ASD compared to TD, linked to ASD risk genes and symptom severity.

This study investigates neural correlates of interpersonal space permeability and flexibility in ASD using fMRI, finding altered brain activity and connectivity associated with preference for larger interpersonal space in ASD.

The paper identifies widespread transcriptomic dysregulation across multiple cortical regions in ASD, showing regional variation and genetic enrichment in synaptic and protein folding genes.

This study examines how children with ASD perceive emotional prosody, finding reduced responses to positive emotions and hemisphere-specific EEG patterns in controls.

This study examines the neural response to auditory stimuli in children with ASD and finds left-hemispheric deficits in the sustained field response.

The paper examines how individual differences in learning behavior relate to attention to detail and stability-flexibility tradeoffs, finding that higher attention to detail correlates with greater flexibility and lower stability in information processing.

This study shows that individuals with autism spectrum disorder (ASD) use allocentric coordinates less during reaching movements compared to typically developing individuals.

The paper compares exploration behavior in typically and non-typically developing pre-walking infants in the presence of their mother using computational analysis.

The paper integrates brain imaging and behavioral data to identify transdiagnostic subgroups in children with ASD, ADHD, or OCD, finding stable groups based on cortical thickness and inattention symptoms.

This study uses a rat model to show that serotonin transporter knockout reduces learning rate and increases exploitation strategy in category learning, suggesting a link to repetitive behaviors in ASD.

The paper examines gene expression and metabolite associations in maternal blood during pregnancy to link prenatal nutrition with neurodevelopmental outcomes in children.

This study investigates PPS remapping in ASD using psychophysical, EEG, and neural network models, finding reduced flexibility due to E/I imbalances.

This study investigates the role of neuroligin in social behavior in C. elegans by using CRISPR/Cas9 to edit an autism-associated mutation and shows its impact on social circuitry.

The paper identifies structural covariation alterations in autism using VBM and links these patterns to core autism symptoms through canonical correlation analysis.

The paper shows that truncating mutations affecting the same exon in autism lead to similar intellectual phenotypes, suggesting exons, not genes, are units of phenotypic impact.

The paper identifies four psychological endophenotypes of the Broader Autism Phenotype using phenotyping in large multiplex families and shows high sensitivity and specificity for BAP classification.

The paper reanalyzes genomic studies of autism using prior knowledge to identify 68 significant biological concepts linked to autism, suggesting their importance in the disease's genetic basis.

This study examines white matter abnormalities in ASD and ADHD using DTI and finds shared and distinct relationships between white matter and sensory profiles.

The paper maps brain connectivity in 16 autism mouse models to identify four subtypes of functional connectivity abnormalities linked to different etiologies.

The paper identifies DNA methylation differences in cord blood samples from newborns later diagnosed with ASD, revealing sex-specific epigenomic signatures linked to neurodevelopmental and X-linked genes.

This study finds that slow online error-correction in autism disrupts sensorimotor synchronization, linking it to social difficulties.

The paper identifies a convergent molecular subtype in ASD by integrating epigenomic and transcriptomic data, revealing shared dysregulation and links to immune processes and genetic risk variants.

The paper evaluates how insufficient eye tracking data affects fixation preference reliability and between-group differences in typically developing and ASD participants.