Autism Spectrum Disorder Research

This study examines gene expression changes in trigeminal ganglia of Shank3b and Cntnap2 mutant mice to understand tactile sensory deficits in autism.

The paper introduces a head-fixed social touch assay in mice to study aversive responses in autism models, finding increased avoidance and aversive facial expressions in ASD models compared to controls.

This study identifies atypical neural oscillation coupling in young children with ASD that predicts speech reception difficulties.

This study examines functional asymmetry in autism, finding reduced leftward asymmetry in language networks and altered developmental trajectories of functional lateralization.

This study examines cognitive learning and brain plasticity in children with autism, finding that learning strategies and neural plasticity differ and are influenced by insistence on sameness.

This study identifies 74 ASD risk genes using whole genome sequencing of multiplex families and finds polygenic risk interacts with rare inherited variants.

The paper maps functional connectivity patterns in the somatosensory cortex during rest and emotional tasks in ASD and neurotypical individuals, linking them to adaptive functioning skills.

This study shows that Mbd2 deficiency in mice leads to cognitive and social deficits, altered gene expression, and DNA methylation patterns similar to those in ASD, suggesting Mbd2 is an epigenetic regulator of ASD-risk genes.

The paper shows that cortical neurons from ASD-associated mutations exhibit early maturation and hyperexcitability compared to controls.

This study uses fractional factorial design to screen environmental factors on neural progenitors, identifying pathway-level changes linked to autism risk.

This study examines age-dependent changes in synaptic transmission in the nucleus accumbens of ASD mouse models and finds that early intervention with rapamycin rescues social deficits.

The paper investigates the role of nitric oxide in autism spectrum disorder, showing that targeting its production reverses ASD-like phenotypes in mouse models and human samples.

The paper uses machine learning to analyze clinical data from the Simons Simplex Collection, finding associations between fever-induced behavioral improvements in ASD and maternal infection, GI dysfunction, and family history of autoimmune and neuropsychiatric disorders.

This study identifies simvastatin and BMS-204352 as potential ASD therapies in a Drosophila Nf1 model by reducing tactile hypersensitivity and synaptic transmission defects.

The paper shows that a PTEN p.I135L mutation and an ASD genetic background together disrupt cortical neurogenesis in iPSC-derived NPCs and organoids.

The paper identifies two subtypes of autism based on functional connectivity, linking hyperconnectivity to excitation-inhibition imbalance in 42% of patients.

The paper investigates neural responses to third-party social interactions in adults with and without autism using EEG frequency tagging, finding no difference in social interaction recognition between groups.

The paper examines the relationship between auditory processing and adaptive behavior in children with ASD using electrophysiological measures and behavioral scales.

The paper replicates and compares intrinsic neural timescales in autism spectrum disorder and schizophrenia, finding reduced timescales in specific brain regions for schizophrenia compared to both typically developed individuals and autism spectrum disorder patients.

The paper identifies novel autism risk genes by analyzing convergent coexpression patterns in brain samples, showing these genes may not be detected by sequencing studies.

The paper identifies neuron-specific transcriptomic changes in ASD temporal cortex, showing neuroinflammation and altered neuronal activity.

This paper develops a mathematical model to link gut serotonin signaling in the enteric nervous system to autism spectrum disorder by scaling findings from mice to humans.

This paper identifies temporal misalignment in auditory brainstem responses (ABR) as an early biomarker for neurodevelopmental derailment, offering a new statistical approach for early detection of autism.

The paper identifies a protein-protein interaction network in human excitatory neurons for 13 ASD risk genes, revealing novel interactions and convergent mechanisms contributing to autism spectrum disorders.

The paper investigates the relationship between glutamate and GABA gene-sets, autism symptoms, and cortical thickness using data from the EU-AIMS LEAP cohort.

This study shows that VPA exposure alters chromatin environment, leading to changes in alternative splicing and gene expression in human cortical neurons, which may contribute to ASD pathogenesis.

This study investigates how brain network architecture relates to ASD-related cortical alterations and polygenic risk for ASD using neuroimaging data from multiple cohorts.

The paper identifies patterns of neural variability in autism using fMRI across tasks, finding greater global connectivity deviations and similar spatial patterns in autistic individuals compared to controls.

This study examines cerebellar morphology and learning deficits in BTBR mice, finding sex differences in cerebellar structure and function compared to C57 controls.

This study examines movement coordination in individuals with ASD using kinematic methods, finding stronger directional constraint and poorer coordination skills compared to typically developing participants.