Eating Disorders and Behaviors

Self-initiated restrictive feeding: a new mouse model of restrictive eating disorders

This paper introduces a mouse model of self-initiated restrictive feeding (SIRF) that mimics features of anorexia nervosa and identifies neural mechanisms involved in the behavior.

Identification of a neural basis orchestrating anorexia nervosa-like phenotypes

This study identifies a neural mechanism in mice where aberrant glutamatergic signaling from MBH SF1/ER neurons induces AN-like behaviors, suggesting BDNF as a therapeutic target.

Relationship between cognitive flexibility and disordered eating attitudes across the non-clinical spectrum

The paper examines the relationship between cognitive flexibility and disordered eating attitudes in a non-clinical sample using performance-based measures of executive function.

Vulnerability and Resilience to Activity-Based Anorexia is Not Sex-Dependent

This study shows that male and female mice exhibit similar vulnerable and resilient phenotypes in activity-based anorexia, suggesting sex differences in anorexia prevalence may be due to sociocultural factors rather than biology.

Midbrain Tet1 dosage defines inter-individual binge-eating susceptibility

This study shows that Tet1 dosage in midbrain neurons determines binge-eating susceptibility in mice and links Tet1 methylation to human binge-eating behavior.

Effects of metabotropic 2/3-glutamate receptor activation and inactivation on activity-based anorexia model in mice.

This study investigates the effects of mGluR2/3 receptor agonist and antagonist on weight loss and physical activity in an activity-based anorexia mouse model.

Altered Brain Network Topology during Successful Response Inhibition in Children with Binge Eating

This study examines neural network differences in children with binge eating compared to controls, finding altered efficiency and connectivity in inhibitory control brain regions.

Polygenicity at the pathway level for anorexia nervosa

This study identifies pathway-level polygenicity in anorexia nervosa by constructing pathway-based polygenic risk scores and finding 497 associated pathways.

Satiety Does Not Silence Food Attention: BMI Modulates Attentional Bias Toward High-Calorie Cues

This study investigates how BMI and satiety affect attentional bias toward high-calorie food cues, finding that BMI modulates this bias even when satiated.

Orthorexia is associated with a paradoxical appetitive gastric response to unhealthy foods

This study investigates the biological mechanisms of orthorexia by examining gastric and facial responses to different types of foods in a non-clinical sample.

Nutritional Ketosis Attenuates Sucrose Bingeing-Induced Behavioral Deficits by Improving Synaptic Plasticity and Anti-Inflammatory Signalling in the Prefrontal Cortex of Male and Female Mice

This study shows that nutritional ketosis reduces sucrose bingeing and related behavioral issues in mice by improving synaptic plasticity and reducing inflammation in the prefrontal cortex.

Reduced GABA transmission onto ventral tegmental area dopamine neurons underlies vulnerability for hyperactivity in a mouse model of Anorexia Nervosa

Rare CRHR2 and GRM8 variants identified as candidate factors associated with eating disorders in Japanese patients.

The paper identifies rare variants in CRHR2 and GRM8 as candidate susceptibility factors for eating disorders in Japanese patients through whole exome sequencing of affected sib-pairs.

Prefrontal cortical protease TACE/ADAM17 is involved in neuroinflammation and stress-related eating alterations

This study shows that TACE/ADAM17 in the prefrontal cortex is involved in stress-induced eating changes and neuroinflammation in rats.

Central extended amygdala neurons in the development of activity-based anorexia

This study identifies PKC-δ neurons in the central extended amygdala as critical regulators of activity-based anorexia, showing their necessity for the development of key anorexia-like behaviors.

The demyelinating agent cuprizone induces a male-specific reduction in binge eating in the binge-prone C57BL/6NJ strain

This study shows that cuprizone reduces binge eating specifically in male C57BL/6NJ mice, suggesting sex-specific mechanisms influenced by genetic background.

Structural neuroimaging signatures of anorexia nervosa features in a mixed sample enriched for disease vulnerability

The paper identifies structural neuroimaging signatures of anorexia nervosa symptoms and risk factors in a sample enriched for disease vulnerability using MRI and DTI data.

Association between uncontrolled eating and caudate responses to reward cues

The paper examines the link between uncontrolled eating and caudate responses to reward cues in normal-weight individuals, finding a positive correlation independent of impulsivity.

Altered brain function in anorexia nervosa and bulimia nervosa: A hierarchical series of task-based fMRI meta-analyses

This paper conducts a meta-analysis of fMRI studies on anorexia nervosa and bulimia nervosa, finding limited convergence in brain activity across different tasks and patient groups.

Negative mood induction effects on problem solving task in women with eating disorders: a multi-method examination

This study examines how negative mood affects problem-solving in women with eating disorders, finding that BED patients use binge-eating as a coping strategy during negative affect.

Neuroanatomical correlates of food addiction and obesity in the general population

This study examines the relationship between food addiction, obesity, and brain structure in a population-based sample, finding no significant neuroanatomical correlates of food addiction but some associations with BMI and orbitofrontal cortex thickness.

Characteristic impairments of goal-directed and habitual control in bulimia nervosa

This study examines the relationship between symptom severity and model-based (MB) and model-free (MF) control in bulimia nervosa (BN), finding impaired MF control distinguishes BN from other groups.

Identifying tissues implicated in Anorexia Nervosa using Transcriptomic Imputation

This paper uses transcriptomic imputation to identify gene-tissue associations linked to Anorexia Nervosa risk, finding significant links in both brain and metabolic tissues.

Genome-Wide Association Study Reveals First Locus for Anorexia Nervosa and Metabolic Correlations

This paper reports the first genome-wide significant locus for anorexia nervosa and identifies genetic correlations with psychiatric and metabolic traits.