Eating Disorders and Behaviors

Activity-based anorexia enhances glutamatergic synaptic transmission and neuronal excitability within the nucleus accumbens of female mice

Integrative GWAS Identifies Novel Loci and Genetic Links Between Psychiatric and Metabolic Factors in Anorexia Nervosa

This study identifies a novel genetic locus near SOX5 and reveals causal links between psychiatric and metabolic factors in anorexia nervosa using integrative GWAS and cross-trait analysis.

Myo-inositol in the Dorsal Anterior Cingulate Cortex is Associated with Anxiety-to-Eat in Anorexia Nervosa

This study examines anxiety-to-eat in anorexia nervosa and finds lower myo-inositol levels in the dorsal anterior cingulate cortex associated with increased anxiety to eat high-energy density foods.

Toward a genetic signature of resistance to activity-based anorexia in striatal projecting cortical neurons

The paper identifies transcriptional differences in striatal projecting cortical neurons that distinguish rats susceptible from resistant to activity-based anorexia, linking gene expression patterns to metabolic and neural functions.

Contextual enhancement on binge-like overconsumption of palatable sugar in mice

This study shows that binge-like sugar consumption in mice is context-dependent and persists even after satiety, similar to habitual behaviors.

Impact of adolescent high-fat diet and psychosocial stress on neuroendocrine stress responses and binge eating behavior in adult male Lewis rats

This study examines how adolescent high-fat diet and psychosocial stress affect neuroendocrine stress responses and binge eating in adult male rats, finding lasting hormonal and behavioral impacts.

An Evolutionary Perspective on the Genetics of Anorexia Nervosa

This study identifies genetic overlaps between anorexia nervosa, BMI, and age at menarche, suggesting evolutionary factors may underlie the development of AN.

Descriptives and genetic correlates of eating disorder diagnostic transitions and presumed remission in the Danish registry.

The paper examines diagnostic transitions and remission in eating disorders using polygenic scores in a Danish cohort, finding significant genetic associations with these outcomes.

Multivariate Neural Patterns of Reward and Anxiety in Adolescents with Anorexia Nervosa

The paper examines neural patterns of reward and anxiety in adolescents with anorexia nervosa using fMRI and representational similarity analysis, finding reduced consistency in reward responses in AN compared to controls.

Shifts in Naturalistic Behaviors Induced by Early Social Isolation Stress are Associated with Adult Binge-like Eating in Female Rats

This study identifies adolescent twitching as a digital biomarker predictive of adult binge-like eating in female rats subjected to early social isolation stress.

Gut microbiota regulates food intake in a rodent model of binge-eating disorder

This study shows that gut microbiota depletion increases food intake during binge-eating episodes in a rodent model.

Nucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure

This study investigates the role of NAc D1 and D2 neurons in balancing feeding and exercise-mediated energy expenditure in mice, finding that manipulating these neurons affects energy balance and weight.

An Excitatory Projection from the Basal Forebrain to the Ventral Tegmental Area Underlying Anorexia-like Phenotypes

The paper identifies a glutamatergic circuit from the basal forebrain to the ventral tegmental area that reduces appetite and causes anorexia-like behaviors by decreasing dopamine release in the nucleus accumbens.

Large-scale exploration of whole-brain structural connectivity in anorexia nervosa: alterations in the connectivity of frontal and subcortical networks

This study examines structural brain connectivity differences in anorexia nervosa using diffusion MRI, finding reduced subcortical connectivity and increased frontal cortical connectivity.

Individual differences in late positive potential amplitude and theta power predict cue-induced eating

The paper shows that individual differences in late positive potential (LPP) amplitude and theta power predict cue-induced eating behavior in response to food rewards.

Corticostriatal dynamics underlying components of binge-like eating in mice

This study examines neural activity in corticostriatal regions during binge-like eating in mice, finding reduced dorsolateral striatum activity in binge eaters compared to controls.

Examination of Onset Trajectories and Persistence of Binge-Like Eating Behavior in Mice after Intermittent Palatable Food Exposure

This study examines binge-like eating behavior in mice after intermittent palatable food exposure, finding that daily access leads to greater escalation and persistence compared to less frequent access.

Temporal dynamics of cognitive flexibility in adolescents with anorexia nervosa: a high density EEG study

This study uses high-density EEG to examine temporal brain dynamics of cognitive flexibility in adolescents with anorexia nervosa and their relationship with anxiety.

The impact of anorexia nervosa and BMI polygenic risk on childhood growth: a 20-year longitudinal population-based study

This study examines the association between polygenic scores for anorexia nervosa and BMI with growth trajectories over 20 years in children, finding sex-specific effects and potential risk interactions.

An EEG study on the effect of being overweight on anticipatory and consummatory reward in response to pleasant taste stimuli

This study examines how overweight individuals respond to food cues and consumption using EEG, finding reduced attention to cues but no difference in reward response.

The Phenome-wide Consequences of Anorexia Nervosa Genes

This study uses transcriptomic imputation to translate AN GWAS findings into gene expression associations, revealing 47 genes linked to AN and their clinical consequences in a biobank cohort.

Aberrant Functional Connectivity between Reward and Inhibitory Control Networks in Pre-Adolescent Binge Eating Disorder

This study identifies reduced functional connectivity between reward and inhibitory control networks in pre-adolescent children with binge eating disorder compared to controls.

Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores

The paper investigates genetic associations between eating disorder symptoms and polygenic scores for psychiatric, metabolic, and anthropometric traits in adolescents.

Neural Representations of Food-Related Attributes in the Human Orbitofrontal Cortex During Choice Deliberation in Anorexia Nervosa

The paper decodes neural representations of taste and health attributes in the OFC during food choices in AN patients and healthy individuals, finding stronger health-related associations in AN.

Relationship between impulsivity, uncontrolled eating and body mass index: a hierarchical model

The paper examines the relationship between impulsivity, uncontrolled eating, and BMI using structural equation models and MRI data, finding associations between impulsivity traits and BMI via uncontrolled eating.

Systems genetic analysis of binge-like eating in a C57BL/6J x DBA/2J-F2 cross

The paper identifies genetic loci influencing binge-like eating in mice using a cross between C57BL/6J and DBA/2J strains, finding sex-specific and combined QTLs.

Prefrontal responses during proactive and reactive inhibition are differentially impacted by stress in anorexia and bulimia nervosa

The paper examines how stress affects proactive and reactive inhibition in bulimia nervosa and anorexia nervosa binge-purging subtype using fMRI and behavioral tasks.

Emotional responsiveness task in emotional distress: correlated of functional neuroimaging in anorexia and bulimia

The paper investigates neural correlates of emotional processing in anorexia and bulimia patients using a distress paradigm, finding no group differences in emotional response but higher clinical scores and alexithymia.

Can't decide how much to EAT? Effort variability for reward is associated with cognitive restraint

The paper examines the relationship between variability in reward seeking and eating behaviors, finding that greater effort variability is linked to lower cognitive restraint.

Differential expression of deltaFosB in reward processing regions between binge eating prone and resistant female rats

The paper compares deltaFosB expression in reward processing regions between binge eating prone and resistant female rats, finding higher expression in BEP rats in certain brain areas.