Hearing, Cochlea, Tinnitus, Genetics

The paper introduces a fast approximation of power-law adaptation for auditory models, improving computational efficiency while maintaining accuracy.

This study identifies Mybl2 as a Wnt-regulated gene that influences boundary formation and sensory epithelium size in the murine cochlea by regulating progenitor niche and sensory domain positioning.

This study shows that thyroid hormone receptors are essential for cochlear outer sulcus development and endocochlear potential maintenance in mice.

This study shows reducing Cldn9 levels pharmacogenetically generates functional inner hair cells in mice, which are durable and resemble normal cells.

This study uses wireless electrocochleography in awake chinchillas to investigate corticofugal modulation during audiovisual crossmodal stimulation, finding no significant differences in auditory responses.

The paper shows that cochlear tuning properties resemble those of an artificial neural network optimized for temporal prediction of natural sounds.

This study examines oscillatory activity in tinnitus patients during auditory and visual attention, finding altered corticofugal pathways and increased theta power in frontal EEG regions.

This study investigates the effects of Tbx2 overexpression on OHC transdifferentiation into IHC-like cells across different ages, finding partial but incomplete reprogramming.

The paper identifies facial motion energy (FME) as a sensitive measure of hearing abilities in mice, showing its reliability and ability to decode speech in noise.

This study investigates the role of CIB2 in mechanotransducer channels of cochlear outer hair cells, finding that a mutation alters channel properties and force sensitivity.

The paper identifies a 'hotspot' and 'frame' in the cochlea's organ of Corti complex, showing that the hotspot moves nonlinearly with sound and the frame is shielded from sub-BF activity.

This study investigates how sensorimotor system modulation affects tinnitus perception using magnetencephalography, finding increased alpha-band connectivity and reduced gamma power in the auditory cortex during relaxation.

This study investigates the genetic interactions between Pou4f3, Gfi1, and Rbm24 in cochlear hair cell survival using mouse models and identifies regulatory elements and expression patterns.

The paper measures cortical activity changes associated with acute tinnitus-like percepts induced by unilateral auditory deprivation using MEG.

The paper examines the distribution of spiral ganglion neuron subtypes along the cochlea and their changes with aging in mice, finding a frequency-dependent pattern and age-related loss of Ic SGNs in the base.

This study shows that infrared laser stimulation of the cochlea can elicit and enhance auditory perception in gerbils, comparable to sound stimuli, and can be used to improve auditory prostheses.

The paper presents a method to generate auditory-nerve spike trains by applying a time- and interval-dependent thinning process to a Poisson process, enabling efficient simulation of neural auditory perception.

This study shows that a specific type of hearing loss in mice can be reversed by reactivating the Spns2 gene within a critical period, restoring auditory function and protecting hair cells.

This study compares human iPSC-derived inner ear organoids with early embryonic inner ear tissue, showing they recapitulate key developmental stages and marker expression.

This study investigates how changes in parvalbumin-expressing inhibitory interneurons in the auditory cortex affect loudness perception and hyperacusis in mice.

This study shows that Oncomodulin modulates spontaneous calcium signaling and afferent innervation maturation in cochlear outer hair cells during development.

The paper identifies a spontaneous mutation in the Ush1g gene in Neil1 knockout mice that causes an expanded phenotype including auditory and vestibular defects.

This study shows noise-induced synaptopathy disproportionately affects long and short sensory hair cells in the mammalian cochlea, with distinct spatial patterns of ribbon synapse loss.

This study shows that newly regenerated inner hair cells in the cochlea lack functional mechanosensory transduction, preventing hearing recovery despite successful cell regeneration.

This study models the loudness of chronic tinnitus using harmonic templates and hearing threshold data to quantify tinnitus severity.

This study shows that reactivating Trim71 enhances the regenerative potential of cochlear supporting cells by promoting de-differentiation and hair cell formation.

This study shows that overexpressing GABAB receptors in auditory cortex of gerbils with developmental hearing loss restores perceptual thresholds for temporal and spectral auditory cues.

This study shows that Cx26 heterozygous mutations increase hearing sensitivity and noise susceptibility, challenging the previous view of their harmlessness.

The paper introduces a modified GPIAS paradigm to assess Zwicker tone perception in rodents and finds a significant increase in the GPIAS effect with notched noise, suggesting perception of the Zwicker tone.

The paper investigates whether metabolic decline causes or is correlated with age-related auditory decline in desert locusts, finding it is correlative, not causative.