Circadian rhythm and melatonin

The paper demonstrates that FlyBox, a tracking system originally for Drosophila, can effectively measure locomotor activity in Anopheles and Aedes mosquitoes over multiple days under different light conditions.

This study evaluates seven methods for detecting rhythmic gene expression and finds they are only consistent for genes with strong rhythmic signals.

The paper uses single-cell in vivo imaging to show light-initiated circadian oscillators in zebrafish, revealing that light exposure initializes cellular clocks during development.

This study examines the presence and functional role of zinc in the circadian system, finding zinc in key areas but no significant effect on circadian responses.

The paper shows that minimal clock models can reproduce essential circadian phenotypes like fast jetlag and seasonal shifts through amplitude effects and twist mechanisms.

The paper shows JETLAG and the DYSCHRONIC-SLOWPOKE complex antagonistically regulate circadian output and synaptic development in Drosophila.

The paper compares photoperiodic responses in gonadal and somatic growth between two vole species, finding species-specific differences in sensitivity and developmental programming of the photoperiodic neuroendocrine system.

The paper tests if S cones contribute to circadian light responses and finds no evidence, suggesting melanopsin is the sole driver.

This study examines how sleep deprivation affects gene expression and chromatin accessibility in mice, revealing long-term genomic regulatory changes.

This study identifies a novel body temperature/Hsp70-Sirt7-Cry1 axis that maintains circadian phase coherence in mouse liver by regulating Sirt7 activity.

This study shows that temperature changes alter the splicing of the timeless gene in Drosophila, affecting TIM protein levels and activity through temperature-sensitive splicing isoforms.

This study identifies CDK5 as a kinase that regulates the mammalian circadian clock by phosphorylating PER2, facilitating its nuclear entry and maintaining circadian period.

The paper introduces a framework to quantify visual and non-visual effects of short-wavelength light filters using factors like luminance, melanopsin activation, color shift, and gamut reduction.

This study identifies DOM splice variants DOM-A and DOM-B as regulators of circadian behavior and sLNv maintenance in Drosophila by modulating pacemaker gene expression and PDF accumulation.

The paper identifies circadian clock genes in Parhyale hawaiensis, finding missing orthologs of cryptochrome 1 and timeless and atypical CLOCK peptide features.

The paper uses CRISPR to disrupt clock genes in specific Drosophila neurons, showing that neither the morning nor evening oscillator alone is sufficient for circadian locomotor activity, indicating a distributed network function.

The paper shows that network communication is important for Drosophila circadian rhythms, with specific neuron groups relying on it for period determination.

The paper identifies a light-mediated pathway in Drosophila that uses PDF-releasing lLNv neurons to adjust circadian rhythms to long day conditions.

The paper shows that weak coupling between feedback loops in circadian clocks leads to dissociated gene expression dynamics at the single-cell level.

The paper characterizes the morphological and physiological properties of three ipRGC subtypes during postnatal development and finds they reach adult-like features at different times.

The paper reanalyses existing data to confirm that melanopsin-weighted quantities improve pupil size modeling using Watson & Yellott's formula.

This study infers coupling and non-linear dynamics between circadian clocks and cell cycles from single-cell microscopy data, revealing temperature-independent, evolutionarily conserved phase-locked states.

ECHO detects and analyzes oscillators in time-course genome-scale data, revealing metabolic regulation through circadian rhythms with changing amplitudes.

The paper investigates circadian oscillations in breast cancer cells using luciferase reporter lines, finding persistent oscillations in low-grade MCF7 cells but not in high-grade MDA-MB-231 cells.

This study identifies miR-210 as a regulator of evening circadian behavior in fruit flies by repressing Fasciclin 2.

The paper shows that a specific subpopulation of ipRGCs projecting to the SCN mediates light's acute effects on body temperature and sleep, while other ipRGCs are involved in circadian regulation.

This study identifies nuclear and plasmotype quantitative trait loci influencing circadian clock robustness to high temperature in wild barley using a doubled haploid population.

The paper develops a mathematical model of the Neurospora crassa circadian clock to elucidate the mechanism of rhythms production and glucose compensation.

The paper shows mammalian Cryptochromes inhibit CRL4Cop1 complex assembly, similar to their function in plants, by interacting with Det1 to repress GR transcription.

Simphony simulates large-scale rhythmic data for benchmarking methods, allowing users to specify experimental designs and feature properties.