Hydrogels: synthesis, properties, applications

This paper designs a hydrogel platform with independently controllable adhesion ligand mobility and viscoelasticity, showing that dual presentation of RGD ligands on both covalent and dynamic networks maximizes endothelial cell adhesion and spreading.

This paper develops a mechanically resilient hydrogel for drug delivery in physically active joints, showing sustained release and reduced cartilage degeneration in a mouse model of post-traumatic osteoarthritis.

This study evaluates GelMA as a scaffold material for intestinal epithelial cells, finding it suitable for permeability, mechanical strength, and biocompatibility.

The paper shows that ball-milled calcium sulfate microparticles improve alginate hydrogel fabrication by creating more stable suspensions, leading to homogeneous gels with consistent mechanical properties for 3D cell culture.

This paper develops e-GLUE, an electroadhesive hydrogel interface that enables prolonged mucosal retention and demonstrates its utility in GI theranostics.

This study develops PEARL, an engineered living material using encapsulated recombinant lactobacilli in alginate beads for controlled protein release over 14 days.

This paper develops an injectable hydrogel with antibacterial properties for tissue engineering applications, showing good biocompatibility and ability to form 3D cell aggregates.

This paper develops tunable macroporous hydrogels via phase separation for cell culture, showing improved cell spreading and migration in porous systems.

This study introduces a PVAc primer layer to improve hydrogel adhesion on silicone implants, validated with two commercial hydrogels.

This study investigates how dynamic hydrogel crosslink strength affects yielding behavior and cell viability during injection, finding that slower yielding transitions enhance cell protection.

This paper develops a thiol-ene click chemistry strategy to modify HPMC for tunable PNP hydrogel properties, enabling controlled drug and cell delivery.

This paper introduces multi-reactive hydrogel nanovials that enable temporal control of secretion capture from antibody-secreting cells, achieving high-purity isolation of antigen-specific hybridomas.

This paper develops a high-swelling composite hydrogel, SwellMA, for 4D bioprinting, showing superior swelling capacity and on-demand swelling-shrinking behavior.

The paper develops a 96-well plate-based screening method to evaluate ELM growth and host compatibility in vitro.

The paper measures covalent bond formation in light-curing hydrogels using NMR to predict their stability under fluid flow.

This study designs PEG-based hydrogels with ionic conductivity by optimizing salt concentration, water content, and network structure to achieve desired mechanical and conductive properties.

This paper develops a biomaterial platform that spatially controls the release of multiple angiogenic growth factors in a time-controlled manner.

This study shows that high-molecular-weight hyaluronic acid hydrogels promote faster glioblastoma cell invasion with leader-follower dynamics compared to low-molecular-weight HA hydrogels.

This study evaluates a hydrogel with porosity and extracellular matrix digest in a rat myocardial infarction model, showing improved cardiac function and neovascularization compared to other hydrogels and PBS.

This paper introduces a microgel platform that precisely controls morphogen gradients to guide vascular morphogenesis in vitro.

This study investigates how different crosslinker architectures affect the viscoelastic properties of dynamic covalent hydrogels, showing that side-chain and telechelic crosslinkers lead to distinct mechanical behaviors.

This study introduces MadSurface, a magnetically actuated hydrogel that dynamically modulates stiffness to influence macrophage phenotype, showing increased CD206 expression in M1-activated THP-1 cells under specific conditions.

This study evaluates how different polysaccharide hydrogel compositions affect the viability and pro-angiogenic function of human adipose-derived stromal cells in vitro and in vivo.

This study creates composite agarose-collagen hydrogels to support chondrocyte culture and mechanotransduction, showing improved mechanical properties and glycosaminoglycan production over 21 days.

This paper develops DNA-based hydrogels that stimulate cellular endocytic pathways and proliferation by mimicking in vivo environments through programmable supramolecular structures.

This study optimizes hyaluronic acid hydrogel viscoelasticity using colloidal particle interactions and response surface methodology, finding mixed nanoparticles yield the highest complex viscosity.

This paper introduces a hydrogel platform with reversible stiffness tuning and cell recovery capabilities to study mechanobiological effects on cell behavior and transcriptome responses.

This paper introduces a synthetic biodegradable hydrogel for 3D culture of human bone cells and analysis of secreted ECM, demonstrating rapid network formation and microfluidic integration.

This paper develops self-healing hydrogels to support choroidal endothelial cell transplantation in a rat model, showing improved cell retention compared to cell suspensions.