Cellular Mechanics and Interactions

This study shows that actin network contractile steady states can be sustained by filament transport rather than assembly/disassembly in an in vitro system.

This study investigates the development of the axonal βII-spectrin periodic skeleton using superresolution imaging and knockout models, revealing stage-specific cytoskeletal remodelling and the role of actin and microtubules in MPS formation.

The paper develops NuTS, a FRET-based sensor to measure tension forces across SUN proteins in living cells and zebrafish, revealing force dynamics during development.

This paper maps apico-basal membrane tension gradients in HeLa cells using optical traps and shows that actin contractility and endocytosis are key factors in creating these tension patterns.

The paper investigates mechanical properties of interfollicular stem cells (ISCs) and their niche during aging, finding ISCs are stiffer than other basal cells and their mechanical environment deteriorates with age.

The paper identifies axonal cytoskeletal responses to mechanical forces and shows that mechanotransduction signaling is critical for axonal integrity.

This study identifies MIG-6/papilin as a regulator of neuronal architecture maintenance by remodeling collagen IV in the extracellular matrix, ensuring neuronal stability under mechanical stress.

The paper analyzes membrane tension relaxation by studying tether force decay, finding a power-law decay with exponent 1/3, confirming a theoretical model of tension diffusion.

This study develops a continuum model to explain how viscoelastic interactions between the cytoskeleton and plasma membrane modulate furrow invagination velocity during Drosophila embryo cellularization.

The paper identifies biomechanical modules that govern larval shape diversity across six cnidarian species and shows how manipulating these modules can transform shapes between species.

The paper introduces Actin Painting, a multicolor fluorescence staining method that distinguishes cell types by their unique F-actin architecture color patterns.

The paper shows that fibulin-1 is delivered on-demand to the basement membrane during stretching in C. elegans, maintaining its structure and enabling repeated organ expansion.

This study shows that swirling motion of breast cancer cells aligns collagen fibers radially, enabling collective invasion by generating contractile stresses.

The paper reveals that human SPIN90 forms dimers to nucleate bidirectional actin filaments via Arp2/3, with structural insights showing conserved dimerisation in metazoans.

This study shows that mechanical constraints can separately affect patterning and gene expression in murine gastruloids, revealing distinct cellular responses to external forces.

The paper shows matrix stiffness induces heritable chromosome changes in cells, linking mechanical stress to genetic instability in solid tumors.

This study uses simulations and live cell imaging to distinguish active and passive mechanical drivers of convergent extension in developing tissues.

This study shows protein condensates induce bundling and remodeling of actin networks through capillary interactions.

This paper introduces genetically encoded mechano-sensors using coiled coils to measure mechanical forces in vivo with diverse readouts and compact design.

The paper identifies a weak, integrin-independent adhesion-clutch mechanism involving shootin1 and L1 that enables rapid cell migration and glioblastoma motility by transmitting weak traction forces.

The paper uses agent-based simulations calibrated with microscopy data to predict and validate how microscopic actin dynamics affect cortical flow speed in C. elegans zygotes.

This study shows that ECM stiffness influences site-specific lung development in organoids by directing cell differentiation and pathway activation.

The paper screens 2,418 kinase inhibitors across five human cell types to identify cell-type specific contractility responses and challenges assumptions about pathway conservation.

The paper identifies two conserved mechanisms controlling cytoplasmic macromolecular diffusion in C. elegans tissues, involving ribosome concentration and the giant KASH protein ANC-1.

This study uses an agent-based model to show that catch-slip bonds enhance the mechanical properties of polymer networks and aid myosin motors in generating contractile forces.

The paper develops two new mechanochemical vertex models of apical constriction during neural tube closure, incorporating Ca2+ signalling and mechanical interactions to better align with experimental observations.

This study investigates how local and long-range mechanical stresses contribute to cephalic furrow formation in Drosophila embryos using computational models and experimental analysis.

This study shows that the Arp2/3 complex is essential for genome integrity and survival of epidermal Langerhans cells, with Arpc4 deficiency leading to DNA damage and premature aging-like decline.