Extracellular vesicles in disease

The paper identifies small non-coding RNA biomarkers in extracellular vesicles from equine osteoarthritis models using small RNA sequencing and bioinformatics analysis.

This study shows milk exosomes cross the blood-brain barrier in mice, affect hippocampal dendritic complexity, and improve spatial learning and seizure resistance.

The paper analyzes extracellular vesicles in amniotic fluid from normal and preeclampsia pregnancies, finding increased CD105+ EVs and antiangiogenic effects in preeclampsia.

The paper shows that exosomes from aged mice can cross the blood-brain barrier and activate glial cells, as indicated by increased GFAP expression.

The paper identifies Stac-positive extracellular vesicles derived from multivesicular bodies that mediate tracheal tube fusion in Drosophila embryos through the action of Arl3, Rab27, and Rab35.

This study shows that extracellular vesicles from Bacteroides thetaiotaomicron affect host immune pathways differently in various cell types and disease states, with implications for IBD therapy.

This study identifies EV-miRNA biomarkers associated with chronic alcohol drinking in non-human primates and links them to inflammatory responses.

This study shows GAPDH facilitates EV biogenesis and enables efficient siRNA delivery to the brain, reducing huntingtin gene expression in a mouse model.

This study investigates the role of small extracellular vesicles in regulating neural stem cell quiescence and proliferation, finding that exosome inhibition affects cell cycle entry and maintenance of quiescence.

This study identifies EVs from human retinal organoids and shows they regulate gene expression in retinal progenitors through miRNA cargo.

The paper examines how TREM2 variants affect microglial exosomal proteomes and their functional impact on neurons.

This paper isolates exosomes from human perilymph to enable molecular diagnosis of sensorineural hearing loss by targeting sensory hair cells using myosin VII expression.

The paper compares methods for milk pre-processing, exosome isolation, and RNA extraction in bovine and human milk, finding that pre-processing does not improve exosome yield, ExoQuick is better for isolation, and TRIzol LS provides highest RNA yield in bovine milk.

This study shows that astrocytic extracellular vesicles can accelerate spontaneous recovery after stroke in rats by promoting anatomical and functional recovery.

This study characterizes the immunomodulatory properties of umbilical cord blood-derived sEV and shows their potential to reduce inflammation in psoriasis models.

This study shows that ASC exosomes alleviate myocardial infarction by delivering miR-31, which targets FIH1 and activates HIF-1α to promote angiogenesis.

The paper analyzes single extracellular vesicles to show that tetraspanin profiles vary by source but not isolation method, and that capture methods can bias apparent protein expression and diagnostic sensitivity.

This study examines neuron-derived extracellular vesicles from plasma to identify size and miRNA cargo changes linked to antidepressant response in depressed patients.

This study reviews EV research from 2012-2020, finding improved methodology and higher citation rates for papers using more characterization methods and MISEV guidelines.

The paper shows that most extracellular miRNAs are secreted non-vesicularly, with only <2% associated with EVs, even though EVs can stabilize miRNAs in serum.

The paper shows L1CAM is not associated with extracellular vesicles in human plasma or CSF and provides tools to evaluate other markers for NDEV isolation.

This study characterizes the lipid composition of brain-derived extracellular vesicles (BDEVs) in Alzheimer's disease and identifies disease-related lipid profile changes.

The paper examines exosomal protein biomarkers in schizophrenia patients and healthy controls, finding elevated GFAP and reduced -II-spectrin in schizophrenia, suggesting astrocytic pathology.

The paper investigates DNA association with extracellular vesicles (EVs) in plasma during exercise, finding that DNA is primarily on the EV surface, not inside.

The paper compares RNA profiles in plasma-derived large and small extracellular vesicles from neurodegenerative disease patients and healthy controls, identifying disease-specific miRNA signatures.

The paper identifies enriched neurodegenerative microglia signatures in EVs from Alzheimer's disease mouse models using proteomic analysis.

The paper uses machine learning to cluster nanosized fluorescent extracellular vesicles, assessing their purity and inflammatory status, and identifies biomarkers for diagnostic profiling.

The paper analyzes proteo-transcriptomic profiles of extracellular vesicles and their donor cancer cells, finding distinct cargo enrichment patterns and suggesting coordinated disposal mechanisms.

This study shows that oligodendrocyte exosome secretion supports axonal transport and neuronal viability, and its impairment leads to axonal degeneration in mouse mutants.

This study identifies PCK2 as a biomarker for renal function 12 months after living donor kidney transplantation using proteomic analysis of urinary extracellular vesicles.