Bipolar Disorder and Treatment

Shared and dissociable features of apathy and reward system dysfunction in bipolar I disorder and schizophrenia

This study compares apathy and reward system dysfunction in bipolar I disorder and schizophrenia, finding comparable apathy severity but distinct neural correlates.

Differences in Genetic Liability for Insomnia and Hypersomnia in Bipolar Disorder Subtypes

This study finds that genetic risk scores for insomnia and sleep duration differ between bipolar I and II subtypes, suggesting distinct genetic liabilities.

Gene expression effects of lithium and valproic acid in a serotonergic cell line

This study uses RNA-Seq to compare gene expression changes in a rat serotonergic cell line exposed to lithium and valproic acid, identifying differentially expressed genes and pathways relevant to mood disorders.

Contribution of rare copy number variants to bipolar disorder risk is limited to schizoaffective cases

The study finds that rare copy number variants (CNVs) contribute to bipolar disorder risk primarily in schizoaffective disorder bipolar type cases, with differences in CNV burden and schizophrenia polygenic risk scores between subtypes.

Polygenic scores for major depressive disorder and depressive symptoms predict response to lithium in patients with bipolar disorder

The paper shows that polygenic scores for depression traits predict lithium response in bipolar disorder patients, with lower genetic load linked to better treatment outcomes.

Genetic pleiotropy between mood disorders, metabolic, and endocrine traits in a multigenerational pedigree

This study identifies genetic pleiotropy between bipolar disorder and metabolic/endocrine traits in a multigenerational Amish pedigree using imputed WGS and polygenic risk scores.

Diverse Pathophysiological Processes Converge on Network Disruption in Mania

The paper identifies network disruptions in brain regions associated with mania in both lesion-induced mania and bipolar disorder.

ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines

This study shows that ErbB4 deletion in locus coeruleus noradrenergic neurons increases neuronal firing and catecholamines, leading to mania-like behaviors that are reversed by lithium or catecholaminergic receptor antagonists.

Characterization of a human-specific tandem repeat associated with bipolar disorder and schizophrenia

The paper identifies a human-specific tandem repeat in the CACNA1C gene associated with bipolar disorder and schizophrenia risk, showing it functions as an enhancer with variable activity linked to disease.

Serotonin Buffers Hippocampal Neuroplasticity And Emotional Behavior

This study investigates how serotonin deficiency affects hippocampal neuroplasticity and emotional behavior in mice, revealing a buffering role of serotonin in adaptive responses to environmental stress.

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

This study identifies 114 genome-wide significant loci for schizophrenia and bipolar disorder, with specific subphenotype associations and four genes distinguishing the disorders.

Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records

This paper validates EHR-based BD phenotyping algorithms by showing their genetic correlation with traditional BD cases, suggesting they identify genetically similar cases.

Fronto-limbic dysconnectivity leads to impaired brain network controllability in young people with bipolar disorder and those at high genetic risk

This study uses network control theory to show that structural connectivity deficits in bipolar disorder and high-risk individuals lead to impaired brain network controllability in regions associated with cognitive and emotional control.

Transcriptomic Imputation of Bipolar Disorder and Bipolar subtypes reveals 29 novel associated genes

This study uses transcriptomic imputation to identify 29 novel genes associated with bipolar disorder and its subtypes, revealing biological pathways related to oxidative stress and circadian rhythms.

High genetic loading for schizophrenia predicts poor response to lithium in patients with bipolar disorder: A polygenic score and cross-trait genetic analysis

This study finds that a higher genetic risk for schizophrenia is linked to poorer lithium response in bipolar disorder patients, suggesting potential for personalized treatment strategies.

Psychosis and the level of mood incongruence in Bipolar Disorder are related to genetic liability for Schizophrenia

The paper investigates the relationship between polygenic risk scores for schizophrenia and psychotic features in bipolar disorder, finding a gradient of genetic liability based on the level of mood-incongruent symptoms.

Genotype-phenotype association mining in bipolar disorder: market research meets complex genetics

The paper applies association rule mining to GWAS data of bipolar disorder to identify novel genotype-phenotype relationships not detected by traditional GWAS methods.

Whole genome linkage analysis in a large Brazilian multigenerational family reveals distinct linkage signals for Bipolar Disorder and Depression.

The paper performs linkage analysis in a large Brazilian family to identify genetic regions associated with bipolar disorder and depression, finding four genome-wide significant and four suggestive linkage regions but no strong joint support across analyses.