Bipolar Disorder and Treatment

Considering social risk alongside genetic risk for bipolar disorder in the All of Us Research Program

The paper integrates social risk factors with genetic risk scores to improve bipolar disorder prediction in the All of Us Research Program, finding social factors have larger effect sizes than genetic risk.

Modulation of Neuronal Excitability and Plasticity by BHLHE41 Conveys Lithium Non-Responsiveness

This study identifies BHLHE41 as a key regulator of lithium response in bipolar disorder by showing its role in neuronal excitability and synaptic plasticity through genetic and cellular analyses.

The toll-like receptor signalling pathway is altered in iPSC-derived cortical networks from people with bipolar disorder.

The paper identifies altered toll-like receptor signalling in iPSC-derived cortical networks from bipolar disorder patients using transcriptome sequencing and differential expression analysis.

A multistable slow-fast model of affective state switching under circadian drive

This paper introduces a slow-fast model of affective dynamics to study how circadian rhythms and perturbations influence transitions between physiological and pathological mood states in bipolar disorder.

Identifying mood instability and circadian rest-activity patterns using digital remote monitoring and actigraphy in participants at risk for bipolar disorder

The paper assesses mood instability and circadian patterns in individuals at risk for bipolar disorder using digital monitoring and actigraphy over 10 weeks.

Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder

This study analyzes structural brain network changes in bipolar disorder, finding widespread connectivity disruptions linked to illness severity and medication use.

The Effects of Bipolar Disorder Granule Cell Hyperexcitability and Lithium Therapy on Pattern Separation in a Computational Model of the Dentate Gyrus

This study uses a computational model of the dentate gyrus to show that lithium therapy improves pattern separation in bipolar disorder patients only by normalizing spontaneous activity, not by reducing cell excitability.

iPSC-Derived Cerebral Organoids Reveal Mitochondrial, Inflammatory and Neuronal Vulnerabilities in Bipolar Disorder

This study uses iPSC-derived cerebral organoids to show mitochondrial and inflammatory dysfunctions in bipolar disorder and tests potential therapeutic interventions.

Lithium Restores Inhibitory Function and Neuronal Excitability through GSK-3β Inhibition in a Bipolar Disorder-Associated Ank3 Variant Mouse Model

Deriving Mendelian Randomization-based Causal Networks of Brain Imaging Phenotypes and Bipolar Disorder

This study uses Mendelian Randomization to identify causal relationships between neuroimaging phenotypes and bipolar disorder, finding that white matter tract variations have larger causal effects on BD.

Pathway-Specific Polygenic Scores for Predicting Clinical Lithium Treatment Response in Patients with Bipolar Disorder

The paper develops pathway-specific polygenic scores to predict lithium treatment response in bipolar disorder and finds associations with specific biological pathways.

Longitudinal Stability of Mood-Related Resting-State Networks in Youth with Symptomatic Bipolar-I/II Disorder

This study examines longitudinal stability of mood-related resting-state networks in youth with bipolar-I/II disorder, finding reduced within-person stability in BD compared to healthy controls.

Frequency-specific changes in prefrontal activity associated with maladaptive belief updating in volatile environments in euthymic bipolar disorder

This study uses MEG and hierarchical Bayesian modeling to show that euthymic bipolar disorder patients anticipate environmental volatility but fail to learn effectively, with altered neural activity in prefrontal regions.

A generalizable normative deep autoencoder for brain morphological anomaly detection: application to the multi-site StratiBip dataset on bipolar disorder in an external validation framework.

This paper develops a deep autoencoder for detecting brain morphology anomalies in bipolar disorder using the StratiBip dataset, finding greater and more heterogeneous deviations in BD patients.

The Impact of Electrophysiological Diversity on Pattern Completion in Lithium Nonresponsive Bipolar Disorder: A Computational Modelling Approach

This paper uses a computational model of the hippocampal CA3 to show that excitability variance in pyramidal cells impairs pattern completion in lithium nonresponsive bipolar disorder patients.

Impaired Visuospatial Working Memory but Preserved Attentional Control in Bipolar Disorder

Strong Genetic Overlaps Between Dimensional and Categorical Models of Bipolar Disorders in a Family Sample

The paper investigates genetic overlaps between categorical and dimensional models of bipolar disorder using a family sample and finds significant heritability and genetic correlations.

Mitochondrial Biomarkers and Metabolic Syndrome in Bipolar Disorder

This study investigates associations between mitochondrial metabolites and metabolic syndrome in bipolar disorder, finding significant links between lactate levels and metabolic syndrome markers, while cell-free mitochondrial DNA showed no association.

Molecular signatures of hyperexcitability and lithium responsiveness in bipolar disorder patient neurons provide alternative therapeutic strategies.

The paper identifies molecular signatures of neuronal hyperexcitability and lithium responsiveness in bipolar disorder neurons, suggesting new therapeutic strategies targeting Akt and AMPK pathways.

Misperceiving momentum: computational mechanisms of biased striatal reward prediction errors in bipolar disorder

This study investigates how bipolar disorder affects striatal reward prediction errors by showing increased momentum bias and reduced striatal-insular connectivity.

Longitudinal hair cortisol in bipolar disorder and a mechanism based on HPA dynamics

This study measures longitudinal cortisol levels in bipolar disorder using hair samples and links cortisol dynamics to mood episodes through mathematical modeling.

Whole blood mitochondrial copy number in clinical populations with mood disorders: a meta-analysis

This study conducts a meta-analysis of mitochondrial DNA copy number in blood samples from individuals with mood disorders, finding increased mtDNAcn in MDD and BD Type II, and decreased in BD Type I.

Genomic SEM Applied to Explore Etiological Divergences in Bipolar Subtypes

This study uses Genomic SEM to analyze genetic differences between bipolar I and II subtypes, finding distinct genetic overlaps with internalizing traits and major depression.

Functional Connectivity of the Cerebellar Vermis in Bipolar Disorder and Associations with Mood

This study examines functional connectivity of the cerebellar vermis in bipolar disorder and its association with mood states, finding altered connectivity patterns linked to depression and mania.

Abnormal features of human self-domestication in bipolar disorder

This study links bipolar disorder to human self-domestication by showing overlapping genes and differential expression in brain regions associated with the disorder.

Cellular genome wide association study identifies common genetic variation influencing lithium induced neural progenitor proliferation

The paper identifies a genetic locus on chr3p21.1 associated with lithium-induced neural progenitor proliferation and links it to bipolar disorder risk through the gene GNL3.

Patterns of convergence and divergence between bipolar disorder type I and type II: evidence from integrative genomic analyses

This study identifies shared and distinct genetic loci between bipolar disorder type I and II using integrative genomic analyses, revealing convergence and divergence in their genetic structures.

Brain derived neurotrophic factor (BDNF) Val66Met polymorphism is not risk factor for bipolar disorder

This meta-analysis evaluates the association between BDNF Val66Met polymorphism and bipolar disorder risk, finding no overall association but a significant link with bipolar II subtype.

Effects of polygenic risk for suicide attempt and risky behavior on brain structure in young people with familial risk of bipolar disorder

The paper examines associations between suicide-related polygenic risk scores and brain structure variability in young people with familial risk of bipolar disorder.

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

Meta-analysis of 41,917 European-ancestry bipolar disorder cases versus 371,549 controls yields 64 risk loci (33 novel), neuronal and synaptic gene enrichment, and 15 eQTL-prioritized genes.