Bipolar Disorder and Treatment

IMPA1 dependent regulation of plasma membrane phosphatidylinositol 4,5-bisphosphate turnover and calcium signalling by lithium

This study shows lithium inhibits IMPA1, reducing PIP2 resynthesis and calcium signaling in neural cells, leading to decreased neuronal excitability.

CREB-pCREB-PER2 feedback loop mediates transition between mania and depression-like behaviors

Patterns of convergence and divergence between bipolar disorder type I and type II: evidence from integrative genomic analyses

This study identifies shared and distinct genetic loci between bipolar disorder type I and II using integrative genomic analyses, revealing convergence and divergence in their genetic structures.

Machine Learning Predicts Treatment Response in Bipolar & Major Depressive Disorders

The paper uses a kernel SVM algorithm with neuromark ICA to predict treatment response in bipolar and major depressive disorders with up to 89% accuracy.

Identification of Key Genes and Biological Pathways in Bipolar Disorder by Bioinformatics and Next Generation Sequencing Data Analysis

This study identifies hub genes and biological pathways in bipolar disorder using NGS data and bioinformatics analysis, revealing potential biomarkers and therapeutic targets.

Information theory characteristics improve the prediction of lithium response in bipolar disorder patients using an SVM classifier

The paper uses information theory features to improve SVM classification of lithium response in bipolar disorder patients, achieving 99% accuracy in distinguishing responders from non-responders.

Brain derived neurotrophic factor (BDNF) Val66Met polymorphism is not risk factor for bipolar disorder

This meta-analysis evaluates the association between BDNF Val66Met polymorphism and bipolar disorder risk, finding no overall association but a significant link with bipolar II subtype.

Effects of polygenic risk for suicide attempt and risky behavior on brain structure in young people with familial risk of bipolar disorder

The paper examines associations between suicide-related polygenic risk scores and brain structure variability in young people with familial risk of bipolar disorder.

A candidate causal variant underlying both enhanced cognitive performance and increased risk of bipolar disorder

The paper identifies a candidate causal variant, rs77910749, that links enhanced cognitive performance with increased bipolar disorder risk through its effect on POU3F2 expression and amygdala function.

Bipolar-associated miR-499-5p controls neuroplasticity by downregulating the Cav1.2 L-type voltage gated calcium channel subunit CACNB2

This study identifies miR-499-5p as a regulator of neuroplasticity in bipolar disorder by targeting CACNB2, leading to impaired dendritogenesis and cognitive function.

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

Meta-analysis of 41,917 European-ancestry bipolar disorder cases versus 371,549 controls yields 64 risk loci (33 novel), neuronal and synaptic gene enrichment, and 15 eQTL-prioritized genes.

Chronic lithium treatment alters the excitatory/inhibitory balance of synaptic networks and reduces mGluR5-PKC signaling

This study shows chronic lithium treatment reduces neuronal excitability and shifts the excitatory/inhibitory balance toward inhibition in mouse cortical neurons.

Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response

This study shows that bipolar disorder patient-derived neurons exhibit circadian rhythm abnormalities, with lithium non-responders showing more severe deficits that can be partially reversed by temperature entrainment.

Exome sequencing in bipolar disorder reveals shared risk gene AKAP11 with schizophrenia

The paper reports exome sequencing findings in bipolar disorder, identifying AKAP11 as a shared risk gene with schizophrenia through ultra-rare protein-truncating variants.

Transcription factor motifs associated with anterior insula gene-expression underlying mood disorder phenotypes

The paper identifies transcription factor motifs associated with gene expression changes in the anterior insula in mood disorders, linking them to immune, homeostatic, and developmental processes.

Neuroimaging Correlates of Emotional Response-Inhibition Discriminate Between Young Depressed Adults With and Without Sub-threshold Bipolar Symptoms

This study uses fMRI to compare emotional response-inhibition patterns between young adults with major depression and subthreshold bipolar symptoms, finding distinct neural activation differences.

Right-sided brain lesions predominate among patients with lesional mania: evidence from a systematic review and pooled lesion analysis

This study confirms right-hemisphere predominance of lesions in lesional mania and identifies specific brain regions associated with mood regulation.

A novel co-segregating DCTN1 splice site variant in a family with Bipolar Disorder may hold the key to understanding the etiology

A novel DCTN1 splice site variant was identified in a family with bipolar disorder and major depressive disorder, potentially causing neuronal dysfunction through altered splicing and protein truncation.

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates

This study examines genetic risk for bipolar disorder in extended families, finding that both common and rare variants contribute to susceptibility, with no significant segregation of large-effect variants.

Longitudinal trajectories of brain age in young individuals at familial risk of mood disorder

The paper examines brain age trajectories in young individuals with and without familial risk of mood disorder, finding decelerated brain maturation in those who later develop the disorder.

Bipolar oscillations between positive and negative mood states in a computational model of Basal Ganglia

This study develops a computational model of the basal ganglia to simulate bipolar oscillations between positive and negative mood states by analyzing reward and risk sensitivity.

Coding and non-coding RNA dysregulation in bipolar disorder

This study identifies dysregulation of coding, long non-coding, circular RNA, and alternative splicing in bipolar disorder using postmortem brain tissue.

Altered EEG resting-state large-scale brain network dynamics in euthymic bipolar disorder patients

This study examines resting-state EEG microstate dynamics in euthymic bipolar disorder patients and finds increased occurrence and coverage of microstate A compared to healthy controls.

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

The paper examines common genetic variants' contribution to bipolar disorder risk in multiplex families and finds higher polygenic risk scores in affected individuals compared to controls and unaffected family members.

Large-scale differential gene expression analysis identifies genes associated with Bipolar Disorder in post-mortem brain

The paper identifies differentially expressed genes in post-mortem brain tissues of bipolar disorder patients and validates them across datasets, finding associations with calcium transport, inflammation, and DNA damage response.

Whole blood transcriptome analysis in bipolar disorder reveals strong lithium effect

The paper analyzes whole blood transcriptomes in bipolar disorder patients and finds that lithium treatment, not the disorder itself, drives most gene expression changes.

Smoking and the risk for bipolar disorder: causal evidence from a bidirectional Mendelian randomization study

This paper uses Mendelian randomization to show smoking increases bipolar disorder risk, but bipolar disorder does not strongly affect smoking behavior.

Studying cellular functions in bipolar disorder: Are there specific predictors of lithium response?

This study investigates cellular phenotypes in bipolar disorder patients with and without lithium response using NPCs and LCLs, finding differences in mitochondrial potential, cell viability, and gene expression related to lithium response.

Genomewide association study identifies 30 loci associated with bipolar disorder

This study identifies 30 genome-wide significant loci associated with bipolar disorder, including novel genes involved in ion channels, neurotransmitters, and synaptic components.

White matter microstructural properties in bipolar disorder and its relationship to the spatial distribution of lithium in the brain

This study examines how lithium treatment in bipolar disorder affects white matter integrity and finds a positive association between lithium distribution and fractional anisotropy.