Olfactory and Sensory Function Studies

Physiology-forward identification of bile acid sensitive vomeronasal receptors

The paper identifies bile acid-sensitive vomeronasal receptors in mice using a physiology-forward approach combining calcium imaging and RNA-seq.

Odor mixture perception: can molecular complexity be a factor determining elemental or configural perception?

The paper investigates how molecular complexity of odorants affects perception of odor mixtures as elemental or configural.

Acid-Sensing Ion Channels Mediate Type III Adenylyl Cyclase-Independent Acid-Sensing of Mouse Olfactory Sensory Neurons

The paper shows that mouse olfactory sensory neurons use acid-sensing ion channels (ASICs) to detect acidic stimuli independently of type III adenylyl cyclase.

Context-dependent odor learning requires the anterior olfactory nucleus

This study shows that the anterior olfactory nucleus (AON) is critical for context-dependent odor learning, while ventral hippocampus (vHC) lesions affect both olfactory and texture context learning.

Olfactory Co-Stimulation Influences Intranasal Somatosensory Perception

This study shows that olfactory co-stimulation improves the localization of weak intranasal somatosensory stimuli when the stimuli are delivered to the same nostril.

Interhemispheric connections between olfactory bulbs improve odor detection

The paper shows that interhemispheric connections in zebrafish olfactory bulbs enhance odor detection by modulating neural responses to pheromones in complex environments.

Widespread Receptor Driven Modulation in Peripheral Olfactory Coding

The paper uses SCAPE microscopy to study odor responses in mouse olfactory neurons, finding widespread receptor modulation in response to odor mixtures.

Dynamic inhibition of sensory responses mediated by an olfactory corticofugal system

This paper shows that activating the anterior olfactory nucleus (AON) suppresses odor responses across different odors and concentrations, and inhibits mitral/tufted cells in the olfactory bulb.

Flexible Representations of Odour Categories in the Mouse Olfactory Bulb

This study shows that mouse mitral cells in the olfactory bulb flexibly represent odour categories based on task demands, with changes in response patterns following learning.

Multi-glomerular projection of single olfactory receptor neurons is conserved among amphibians

The paper investigates axonal branching patterns of olfactory receptor neurons in amphibians and challenges the unbranched axon concept as a universal vertebrate feature.

Non-invasive recording from the human olfactory bulb

This paper introduces a non-invasive method to record neural activity from the human olfactory bulb using EEG, termed Electrobulbogram (EBG), which is reliable and localized to the OB.

Comparison of odor responses of homologous medial and lateral glomeruli mapped in the olfactory bulb of the mouse

The paper compares odor responses in medial and lateral glomeruli in the mouse olfactory bulb, finding that medial glomeruli show stronger respiration-linked calcium fluctuations.

Whitening of odor representations by the wiring diagram of the olfactory bulb

The paper shows that the olfactory bulb's wiring diagram enables odor representation whitening by suppressing redundant responses through reciprocal inhibition.

Spatially organized genomic and physiological heterogeneity of the olfactory bulb mitral cell layer

The paper clusters spatial gene expression profiles in the olfactory bulb mitral cell layer and identifies dorsoventral physiological differences.

Computational exploration of molecular receptive fields in the olfactory bulb reveals a glomerulus-centric chemical map.

The paper identifies molecular receptive ranges of olfactory glomeruli using machine learning and physiological measurements, revealing a chemical map underlying their arrangement.

Functions of olfactory receptors are decoded from their sequence

The paper uses machine learning to predict olfactory receptor-odorant pairs and basal activity from sequence data, identifying key residues that determine selectivity and activity.

Aversive Learning Increases Release Probability of Olfactory Sensory Neurons

This study shows that aversive learning increases the release probability of olfactory sensory neurons in mice, correlating with freezing behavior during fear retrieval.

Adapting the novel-object recognition task to quantify how much attention rodents allocate to motivationally-salient objects

This study adapts the novel-object recognition task to measure how C57BL/6J male mice allocate attention to objects labeled with female odour versus other odours or novel objects.

Structural changes in secondary, but not primary, sensory cortex in individuals with congenital olfactory sensory loss

The paper examines structural brain changes in individuals with congenital olfactory loss, finding atrophy in olfactory sulci and increased volume in medial orbital gyri, suggesting differential plasticity in secondary vs. primary olfactory cortex.

Robust odor coding across states in piriform cortex requires recurrent circuitry: evidence for pattern completion in an associative network

The paper shows that recurrent circuitry in piriform cortex stabilizes odor representations despite degraded input, supporting pattern completion in an associative network.

Seeing cells smell: Dynamic optical measurements of Ca2+ and cAMP signaling from Olfactory Receptors transiently expressed in HEK293TN cells

The paper demonstrates real-time detection of Ca2+ and cAMP signaling from olfactory receptors expressed in HEK293TN cells using fluorescent biosensors.

Elaborate expansion of syntenic V1R hotspots correlates with high species diversity in nocturnal mouse and dwarf lemurs

The paper compares V1R gene diversity in nocturnal and diurnal lemurs, finding a correlation between nocturnality and expanded V1R repertoires.

Sequence-based prediction of olfactory receptor responses

The paper predicts olfactory receptor responses to odors using sequence data and conspecific receptor responses, showing significant agreement with experiments.

Similarity and strength of glomerular odor representations define neural metric of sniff-invariant discrimination time

The paper shows that glomerular odor representations' similarity and activation strength determine the time needed for odor discrimination, independent of sniffing behavior.

A Subset of Olfactory Sensory Neurons Express Forkhead Box J1-Driven eGFP

The paper identifies a subset of olfactory and vomeronasal sensory neurons expressing Foxj1-driven eGFP, lacking motile cilia but showing distinct spatial distribution and axonal termination patterns.

Smad4 signaling establishes the somatosensory map of basal vomeronasal sensory neurons

This study shows that Smad4 signaling is essential for the development, function, and circuit formation of basal vomeronasal sensory neurons.

Photoactivation of olfactory sensory neurons does not affect action potential conduction in individual trigeminal sensory axons innervating the rodent nasal cavity

The paper investigates interactions between olfactory and trigeminal systems in the nasal cavity and finds no evidence of cross-talk between them.

Rapid Sensorimotor Reinforcement in the Olfactory Striatum

This study shows that the olfactory tubercle, not the posterior piriform cortex, rapidly encodes reward category during odor-reward learning, preceding motor actions.

Temporary anosmia in mice following nasal lavage with dilute detergent solution

This paper introduces a recoverable anosmia protocol in mice using nasal detergent lavage, enabling behavioral and biochemical studies of olfactory function.

Mosaic representations of odors in the input and output layers of the mouse olfactory bulb

The paper examines how odor features are represented in the input and output layers of the mouse olfactory bulb, finding that physical-chemical descriptors poorly predict neuronal representations.