Olfactory and Sensory Function Studies

Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic

The paper identifies sexually dimorphic olfactory sensory neurons in mice that respond to male-specific semiochemicals and show plasticity when exposed to sex-combined housing.

SARS-CoV-2 receptor and entry genes are expressed by sustentacular cells in the human olfactory neuroepithelium

The paper identifies sustentacular cells in the human olfactory neuroepithelium as expressing ACE2 and TMPRSS2, suggesting they may serve as entry points for SARS-CoV-2.

Disease specific alterations in the olfactory mucosa of patients with Alzheimer's disease

This study identifies disease-specific gene expression and protein secretion patterns in olfactory mucosa cells from Alzheimer's patients, revealing potential diagnostic and mechanistic insights.

Mixture coding and segmentation in the anterior piriform cortex

This study investigates how the piriform cortex represents and segments odor mixtures, finding that normalization models explain responses and that individual components can be identified from population activity.

The nasopalatine ducts of the mouse conserve a functional role in pheromone signaling

This study shows that mouse nasopalatine ducts are crucial for pheromone signaling by enabling VNO function and associated social behaviors.

Diverse dynamics of glutamatergic input from sensory neurons underlie heterogeneous response patterns of olfactory bulb outputs in vivo

The paper investigates the dynamics of glutamatergic input from sensory neurons to MT cells in the olfactory bulb and finds that these dynamics, rather than OB circuit mechanisms, explain the diversity in MT cell responses.

The diagonal band of broca regulates olfactory-mediated behaviors by modulating odor-evoked responses within the olfactory bulb

This study shows that HDB projections to the olfactory bulb modulate odor-evoked responses and are critical for olfactory-mediated habituation and discrimination behaviors.

Women show enhanced attractiveness ratings and neural processing of male faces associated with male chemosensory signals

The paper shows that women's attractiveness ratings and neural responses to male faces are influenced by male chemosensory signals, even when they cannot consciously detect the association.

Decoding Odor Mixtures in the Dog Brain: An Awake fMRI Study

This study uses awake fMRI in dogs to show that odor mixtures are processed configurally in the brain, with better classification using multiclass models over multilabel models.

Differences in Chemo-signaling Compound-Evoked Brain Activity in Male and Female Young Adults: A Pilot Study in the Role of Sexual Dimorphism in Olfactory Chemo-Signaling

This study investigates sex differences in brain activity evoked by chemo-signaling compounds in young adults, finding sexually dimorphic responses to pheromones but not to lavender.

The Imposition of Value on Odor: Transient and Persistent Representations of Odor Value in Prefrontal Cortex

This study shows how odor representations shift from piriform cortex to prefrontal cortex, with transient and persistent value-based representations emerging after learning.

Intranasal Administration of Functionalized Soot Particles Disrupts Olfactory Sensory Neuron Progenitor Cells in the Neuroepithelium

This study shows that oxygen-functionalized soots reduce olfactory progenitor cells in mice, potentially affecting CSF drainage and linking air pollution to neurodegenerative disease risk.

Elevated ACE2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication

The paper identifies ACE2 enrichment in the olfactory neuroepithelium, linking it to SARS-CoV-2 entry, anosmia, and potential intranasal therapy targets.

Alterations in odor hedonics in the 5XFAD Alzheimer's disease mouse model and the influence of sex

The paper investigates odor hedonics in 5XFAD Alzheimer's disease mice, finding prolonged odor investigation and altered preferences in females.

Tuning of ventral tenia tecta neurons of the olfactory cortex to distinct scenes of feeding behavior

The paper investigates how vTT neurons in mice are tuned to different scenes during feeding behaviors, showing scene-specific firing patterns and top-down modulation.

Rapid Bayesian learning in the mammalian olfactory system

This study formulates olfactory learning as a Bayesian optimization process and shows a computational model can identify odors from few observations and learn reward associations with a plausible neural architecture.

The effect of odor enrichment on olfactory acuity: Olfactometric testing in mice using two mirror-molecular pairs.

This study investigates the effect of odor enrichment on olfactory acuity in mice using two mirror-molecular pairs, finding no improvement in discrimination or detection abilities.

Normal Olfactory Functional Connectivity Despite Life-Long Absence of Olfactory Experiences

The paper compares functional connectivity in olfactory cortex between individuals with congenital anosmia and controls, finding no atypical connectivity despite lifelong olfactory sensory loss.

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

The paper identifies non-neuronal cell types in the olfactory system expressing SARS-CoV-2 entry genes, suggesting indirect mechanisms for COVID-19-associated anosmia.

Antagonistic odor interactions in olfactory sensory neurons are widespread in freely breathing mice

The paper shows that antagonistic interactions between odors are common in olfactory sensory neurons of freely breathing mice, helping to normalize activity and reduce saturation in complex odor mixtures.

Input dependent modulation of olfactory bulb activity by GABAergic basal forebrain projections

This study compares the effects of optogenetic manipulation of cholinergic and GABAergic basal forebrain projections on mitral/tufted cell activity in the olfactory bulb, revealing input-dependent modulation.

A neural system that represents the association of odors with rewarded outcomes and promotes behavioral engagement

The paper investigates how odor-reward associations are represented in brain regions and how these representations influence behavior during learning.

Differential impacts of repeated sampling on odor representations by genetically-defined mitral and tufted cell subpopulations in the mouse olfactory bulb

The paper investigates how repeated odor sampling affects odor representations in mitral and tufted cells in the mouse olfactory bulb, finding differential impacts between cell types.

Effect of interglomerular inhibitory networks on olfactory bulb odor representations

The paper uses a computational model to study how interglomerular inhibitory networks in the mouse olfactory bulb shape odor representations based on connectivity schemes and sensory input.

Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception

The paper uses synthetic odors to uncover how neural activity patterns relate to olfactory perception by analyzing spatial and temporal coding.

Mate discrimination among subspecies through a conserved olfactory pathway

The paper identifies two male-specific pheromones in Drosophila mojavensis subspecies and shows how they contribute to sexual isolation through conserved sensory pathways and differential interpretation.

Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters

This study shows SARS-CoV-2 infection causes rapid and severe damage to the olfactory epithelium in golden Syrian hamsters, primarily through infection of sustentacular cells and immune cell infiltration, leading to anosmia.

Deficits in olfactory sensitivity in a mouse model of Parkinson's disease revealed by plethysmography of odor-evoked sniffing

This study shows that injecting α-synuclein fibrils into the olfactory bulb of mice reduces odor detection sensitivity, detected by plethysmography but not buried pellet tests.

Paradoxically sparse chemosensory tuning in broadly-integrating external granule cells in the mouse accessory olfactory bulb

The paper studies chemosensory tuning in mouse accessory olfactory bulb external granule cells, finding their sparser tuning compared to mitral cells, suggesting distinct functional roles.

Widespread inhibition, antagonism, and synergy in mouse olfactory sensory neurons in vivo

The paper investigates odor responses in mouse olfactory sensory neurons, finding inhibition, antagonism, and synergy at the peripheral stage.