Sleep and Wakefulness Research

This study investigates how tapeworm infection affects sleep behavior in three-spined sticklebacks, finding altered sleep patterns at different timepoints post-exposure.

The paper examines cortical acetylcholine dynamics during behavioral state transitions, finding that axon activity and behavior predict ACh levels.

This study shows that vibration-induced sleep in Drosophila improves learning, memory, and clearance of harmful proteins associated with Alzheimer's disease.

This study shows that reducing SWS or REM by 50% does not impair memory consolidation and may even improve psychomotor vigilance and procedural skills.

This study uses closed-loop auditory stimulation in mice to enhance slow-wave activity, improving sleep quality in Alzheimer's and Parkinson's disease models.

This study shows that closed-loop auditory stimulation can modulate alpha and theta oscillations during REM sleep in a phase-dependent manner, altering power and frequency.

This study shows that scheduled feeding improves sleep patterns in male but not female Huntington's disease mouse models.

This study shows sleep deprivation reduces excitatory synapse diversity in the cortex and hippocampus of mice, while maintaining total synapse density.

This study investigates the role of sleep in motor skill maintenance through experiments showing sleep enhances memory retention when training occurs before bedtime.

This study weakens aversive memories during sleep by reactivating positive memories, reducing recall and increasing positive memory intrusions.

This study identifies CaMKII-dependent activity of cortical parvalbumin neurons as essential for homeostatic sleep rebound following prolonged wakefulness.

This study shows that astrocytic lactate supply via MCT4 and MCT2 is essential for maintaining wakefulness and sleep stability by supporting orexinergic neuron activity.

This study examines how the respiratory cycle modulates sleep spindles and slow waves during N2 sleep in humans, finding significant coupling between spindles and respiration phases.

This study interviews patients with Non-REM parasomnias to characterize the variability in consciousness and environmental disconnection during episodes, finding a spectrum from automatic behaviors to dream-like conscious experiences.

This paper identifies a REM-active basal ganglia circuit in mice that regulates REM sleep and anxiety by showing its role in sleep duration and behavioral responses to aversive stimuli.

The paper shows that NREM and REM sleep play distinct roles in forming inferential knowledge, with NREM organizing learned information and REM computing inferences from it.

The paper shows the first-night effect reduces sleep's benefit on visual plasticity and alters neurochemical processes during sleep.

This study shows that spindle-locked ripples in human NREM sleep are critical for memory reactivation, supporting their role in memory consolidation.

This study identifies GABAergic neurons in the hypothalamic preoptic area that regulate REM sleep homeostasis by responding to REM sleep restriction and mediating rebound.

This study shows that targeted memory reactivation during NREM sleep improves neutral memory but not negative memory, with sleep spindles mediating the effect for neutral items.

This paper identifies Npas1+ neurons in the basal forebrain as a major GABAergic subpopulation involved in wakefulness and sleep regulation.

This study shows that optogenetic stimulation of cortical neurons can awaken mice from sleep, coma, and anesthesia, indicating cortical sufficiency for arousal.

This study identifies an EEG signature that tracks MCH neuron activity and predicts cocaine seeking behavior in rats.

This study shows that Dif, an NFκB transcription factor in Drosophila, regulates daily sleep and recovery sleep after sleep deprivation, with effects mediated through neuronal pathways.

This study investigates how verbal and non-verbal retrieval cues affect memory reactivation in sleep, finding verbal cues elicit stronger spindle activity than non-verbal cues.

The paper investigates how sleep reactivation affects memory transformation by improving distinguishing features while worsening shared features of object memories.

This study shows that Purkinje cell dysfunction in ataxic mice disrupts sleep architecture, with reduced wakefulness and REM sleep and increased NREM sleep.

This study investigates how PACAP and CRF, two stress peptides, affect sleep architecture in mice, finding distinct impacts on sleep stages and behavior.