Cytokine Signaling Pathways and Interactions

The paper shows that lymphocytes and monocytes suppress IL-10R, IL-6R, and IL-2Rβγ signaling under high cytokine concentrations, mediated by cytokines that do not induce their own pSTATs.

This study identifies an IL-2 mutant that disrupts alternative signaling by blocking CD25-CCR7 complex formation while preserving canonical signaling.

This study identifies a JAK-independent mechanism of STAT3 activation in RA through TCR-dependent phosphorylation at the immunological synapse, suggesting a new therapeutic target.

This study shows that Rbfox1 and mir-33 regulate Stat92E transcript stability and alternative splicing during Drosophila adult myogenesis, influencing JAK/STAT signaling outcomes.

This study investigates the association between JAK-STAT pathway gene expression and hypertension in Kenyan women with breast cancer, finding significant correlations between specific genes and blood pressure metrics.

The paper investigates how two STAT5B SH2 domain variants affect mammary tissue development and lactation by altering enhancer recognition and gene regulation in mice.

The paper characterizes an Osmr conditional knockout mouse model, showing variable tissue-dependent effects on OSMR mRNA and protein expression.

The paper develops a computational model to predict the role of IL-6 trans-signaling in endothelial cell signaling, showing it dominates over classic signaling in activating key pathways.

The paper investigates how receptor and kinase abundance imbalances affect cytokine signaling in T cells, finding that higher receptor levels can weaken signaling responses.

The paper identifies a mutual repression network between JNK/AP-1 and JAK/STAT signaling that spatially segregates cell behaviors during tissue regeneration in Drosophila.

The paper shows FSH activates JAK3 in bovine granulosa cells, increasing phosphorylation of STAT3 and other proteins, and modulating steroidogenesis and proliferation.

This study identifies a gp130 signaling module that enhances tissue regeneration and prevents pathological outcomes by modulating cellular stress responses.

The paper investigates the role of SOCS1/SOCS3 immune axis in modulating IL6 signaling during Leishmanial infection and proposes a synthetic biology approach to restore pro-inflammatory cytokine expression.

This paper identifies Y705 and S727 phosphorylation sites on STAT3 as critical for its mitochondrial import and transcriptional activity, which regulate stem cell proliferation in zebrafish and mouse models.

This study compares two ovine GCSF variants, finding that GCSFv2 has higher activity and mRNA expression than GCSFv1, and that the C-terminal region is most effective in promoting neutrophil maturation and progenitor cell functions.

The paper investigates the BDNF-induced JAK/STAT pathway in neurons, identifying its role in regulating ion channels, neurotransmitter receptors, and synaptic plasticity through non-canonical STAT3 activation.

The paper identifies an IL15-STAT1-IRX3 pathway that promotes T cell survival and reveals its therapeutic potential for immune malignancies, obesity, and autoimmune diseases.