Axon Guidance and Neuronal Signaling

The paper evaluates C. elegans connectomes to assess whether neuronal adjacency predicts synaptic connectivity, supporting Peters rule over the lock-and-key model.

The paper identifies fourteen guidance genes essential for adult Drosophila nervous system survival and motility through RNAi screening, highlighting the role of Semaphorins and Plexins in motoneuron survival.

This paper identifies a DCC variant causing mirror movement disorder and shows it disrupts the DCC-WAVE regulatory complex interaction, essential for Netrin-1 signaling.

The paper identifies Nhlh1 and Nhlh2 as transcription factors that globally regulate commissural axon laterality through Robo3 activation in mammals.

This study identifies the Vap33/Eph/Vav/Cdc42 complex as a temporal regulator of primary dendrite outgrowth in Drosophila neurons by integrating signals from multiple pathways.

The paper shows that stochastic developmental processes explain individual wiring variation in the brain.

This study shows that spontaneous retinal waves before visual experience shape connectivity in non-image forming nuclei by analyzing transcriptomic profiles of RGCs in mice.

This study determines the structure of the GPC3-Unc5D complex and shows its role in guiding neuronal and cancer cell migration.

The paper identifies molecular markers distinguishing cortico-brainstem and corticospinal projection neurons during development using single-cell RNA sequencing.

This study shows prenatal alcohol exposure alters axon formation and Robo/Slit guidance cue expression in the internal capsule of E15.5 embryos, affecting axon crossing differently in males and females.

The paper identifies two temporally distinct roles of EGFR in coupling axonal branching to synaptic stabilization during Drosophila visual system development.

The paper reanalyzes EphA3 knockin mouse data to show stochasticity in retinotopic map formation arises from retinal variability rather than collicular mechanisms.

This study identifies PP2A phosphatase as a regulator of cell-type specific dendritic morphology in Drosophila neurons, with distinct roles in promoting branching in Class IV neurons and restricting arborization in Class I neurons.

This study shows that mechanosensitive DEG/ENaC channels are essential for dendritic arbor morphogenesis in C. elegans by mediating mechanical feedback during ligand-mediated guidance.

The paper shows that tubulin polyglutamylation regulates microtubule-severing enzymes in axon guidance, with TTLL6 and TTLL11 having distinct roles in zebrafish and mammalian neurons.

This study identifies PFTK1's role in axogenesis by regulating RhoA phosphorylation and activity during CNS development in Drosophila and mice.

This study shows that phosphorylation at serine 1283 in Reelin is critical for its function in brain development, as disrupting this site leads to neuronal migration defects and altered Reelin levels.

This study shows Nab2 regulates dendritic arbors and axon projection through the planar cell polarity pathway in Drosophila.

The paper shows that Notch-dependent fate choice in Drosophila medulla neurons regulates Netrin expression, which controls axon guidance and neuropil organization in the optic lobe.

The paper systematically profiles dprs and DIPs expression in Drosophila larval neurons to identify cell surface codes involved in synaptic recognition.

This paper introduces an agent-based model of retinotectal axon projection using gradient following and receptor-ligand interactions to replicate experimental results without competition.

This study shows that Fmn2b is essential for motor neuron development and function in zebrafish, with loss-of-function leading to motor deficits and impaired axon branching.

The paper shows that syntaxin-1 is required for UNC5/Netrin-1-dependent macropinocytosis and chemorepulsion in axonal guidance.

This study shows that miRNA-22a in blood vessels guides motor neuron pathfinding in zebrafish via exosomes and regulates vascular and neuronal patterning.

The paper identifies Lumican as a factor regulating axon collateralization in cervical corticospinal neurons through inter-neuronal crosstalk.

The paper investigates the role of Sema3C in guiding MGE-derived cortical interneurons during migration, showing that Nrp1-expressing interneurons are attracted to Sema3C gradients.

This study uses a new transgenic zebrafish model to show that activity-dependent refinement of nasal retinal projections sharpens the antero-posterior retinotopic map in real-time.

This study identifies a homeo-immunoglobulin code that specifies single-cell specific connections between motoneurons and target muscles through combinatorial immunoglobulin domain proteins.

The paper shows that axon initiation in spinal neurons occurs at a stereotyped position in vivo, independent of microtubule dynamics and laminin cues.

This study investigates how photoreceptor identity influences axon extension velocity and circuit formation in Drosophila.