Axon Guidance and Neuronal Signaling

This study shows that autophagy is essential for midbrain dopaminergic axon development and responsiveness to guidance cues, with knockout of autophagy genes causing axonal swellings and impaired branching.

The paper develops a computational model to explain dendrite branchlet morphology in Drosophila neurons by analyzing actin-modulatory protein roles and dynamics.

This study shows that an autism-associated CACNA1C variant disrupts neuronal polarity and axon termination in C. elegans ALM neurons.

This study identifies novel effector proteins of EPH receptors and shows they regulate cell polarity and morphogenesis through PAR-3 and CSK signaling.

The paper identifies CAP1 as a novel actin regulator in growth cones that is critical for neuron connectivity and function.

The paper investigates how deterministic and stochastic mechanisms shape dendritic branching in Drosophila neurons, finding that primary branches grow deterministically while secondary branches exhibit stochastic behavior influenced by geometric feedback.

The paper develops a mathematical model of dendritic growth that optimizes wiring efficiency and space-filling through two complementary strategies.

This study shows that NMDA receptors, specifically NR2B-containing ones, control callosal axonal projections in the primary somatosensory cortex through interactions with EPHRIN-B/EPHB, independent of ion channel function.

The paper shows multicellular rosettes organize the nerve ring neuropil in C. elegans by guiding axon outgrowth and structural formation.

This study shows NUAK1 regulates cortical axon branching by modulating mitochondrial metabolism and positioning, with functional rescue observed through mitochondrial function upregulation.

This paper investigates the role of Rap/Fzr in Drosophila retinal axon targeting and its interactions with Loco and Liprin-alpha, showing defects in axon projection in mutants and enhanced phenotypes in double mutants.

The paper shows that reduced Tuba1a impairs axon guidance but supports neuronal migration, revealing TUBA1A's role in microtubule dynamics during neurodevelopment.

The paper shows that SlitC-PlxnA1 signaling limits growth cone exploration to ensure forward midline navigation, not post-crossing barrier mechanisms.

This study shows that βIII spectrin regulates dendrite planarity by controlling microtubule dynamics and preventing abnormal lateral branching in Purkinje cells.

This study investigates the role of Odd-skipped in Drosophila CNS development, showing it regulates neurite morphology, affects cell survival, and influences synaptic formation and neural function.

The paper investigates how growth cones navigate microtubule-dependent stepwise advance on laminin-1 by testing the role of actin protrusions and microtubule entry.

This study identifies Robo2 as a synaptogenic molecule critical for excitatory synapse formation and spatial coding in hippocampal circuits.

This study shows Retinoic Acid regulates Hgf/Met signaling dynamics to organize the vagus motor topographic map in zebrafish.

This study shows RACK1 is required for BDNF-induced local translation of β-actin mRNA at growth cone point contacts, which regulates axon guidance and development.

The paper investigates how spiral ganglion neurons navigate through the cochlea by interacting with glia and other cellular structures to form ordered connections with hair cells.

The paper quantifies developmental dynamics of retinocollicular projection ordering in mice and shows a combined activity-molecular model can capture segregation and convergence changes.

This study shows that zebrafish dscaml1 is crucial for retinal patterning and oculomotor circuit function, with mutations causing deficits in gaze stabilization and saccade fatigue similar to human ocular motor apraxia.

The paper investigates how commissural axons develop sensitivity to midline repellents through receptor dynamics during navigation, revealing spatial and temporal receptor profiles that enable discrimination of repulsive signals.

The paper shows that muscle precursors guide oculomotor nerve growth and branching in mouse embryos by acting as intermediate targets.

This study identifies Ret51 as a marker for pioneer neurons and shows its role in axon growth and growth cone dynamics through retrograde transport.

The paper identifies key proteins involved in axon guidance disorders using systems biology tools and analyzes their molecular mechanisms.

The paper identifies that trigeminal ganglia axons are the earliest afferent projections to the mouse cerebellum, preceding Purkinje cell development.