Renal and related cancers

Characterization of splice isoform switching during human kidney development

The paper identifies splice isoform switching during human kidney development and links it to Wilms tumor by analyzing RNA sequencing data from fetal kidney stages and tumor models.

Analysis the Detailed Process of Glomerular Capillary Formation Using Immunofluorescence Perform With Ultrathick Section

The paper uses immunofluorescence on ultra-thick sections of mouse kidneys to detail the process of glomerular capillary formation, identifying key stages and molecular factors involved.

Ureteric Bud Cells Programmed from Embryonic Stem Cells Obtain Competence for Secondary Induction in the Kidney

This study develops a method to generate ureteric bud progenitor cells from mouse embryonic stem cells, which can induce nephrogenesis when co-cultured with metanephric mesenchyme.

Molecular determinants of WNT9b responsiveness in nephron progenitor cells

The paper identifies Fzd5, Lrp6, and Rspon1 as critical components required for WNT9b responsiveness in nephron progenitor cells.

A Comprehensive Molecular Portrait of Human Urine-derived Renal Progenitor Cells

This paper identifies and characterizes human urine-derived renal progenitor cells, revealing their molecular identity, reprogramming potential, and gene regulatory mechanisms for self-renewal and differentiation.

Dynamin binding protein is required for Xenopus laevis kidney development

This study shows that Dnmbp is essential for nephrogenesis in Xenopus laevis, with knockdown and overexpression leading to developmental defects in kidney structures.

High throughput single cell RNA-seq of developing mouse kidney and human kidney organoids reveals a roadmap for recreating the kidney

The paper uses single-cell RNA-seq to analyze developing mouse kidney and human kidney organoids, identifying cell clusters and revealing insights into kidney development and organoid maturation.

Defining the dynamic chromatin landscape of nephron progenitors

The paper examines the chromatin landscape of nephron progenitors across age, identifying age-related changes in chromatin accessibility and regulatory regions that suggest old progenitors are epigenetically primed for differentiation.

Tfap2a is a novel gatekeeper of differentiation in renal progenitors during kidney development

This study identifies tfap2a as a key regulator of distal nephron segment differentiation in zebrafish, revealing its role in controlling gene regulatory networks and specialized metabolic functions.

Wnt/β-catenin signaling is required for the development of multiple nephron segments

This study shows that Wnt/β-catenin signaling is critical for the development of multiple nephron segments in mice.

Single-cell analysis of progenitor cell dynamics and lineage specification of the human fetal kidney

This study uses single-cell transcriptomics to analyze human fetal kidney development, identifying 17 cell clusters and their lineage trajectories.

Ex vivo live cell tracking in kidney organoids using light sheet fluorescence microscopy

This study uses light sheet fluorescence microscopy to track cell fate and morphological development in kidney organoids over 15 hours.

Small non-coding RNA expression in developing mouse nephron progenitor cells

The paper presents miRNA profiling data for mouse nephron progenitors, identifying differentially expressed miRNAs and novel miRNAs, and provides them as a public resource for kidney development studies.