Renal and related cancers

Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids

This paper develops a synthetic niche to expand nephron progenitor cells, enabling organoid generation and CRISPR screening for kidney development and disease.

Structural development of the human fetal kidney: new stages and cellular dynamics in nephrogenesis

This study creates an interactive atlas of human fetal kidney development using electron microscopy, identifying new stages and cellular dynamics in nephrogenesis.

Renal Interstitial Cells Promote Nephron Regeneration by Secreting Prostaglandin E2

The paper identifies renal interstitial cells (RICs) as key providers of a microenvironment for nephron regeneration in zebrafish, showing they secrete PGE2 to promote progenitor cell proliferation and nephron maturation.

The developing kidney actively negotiates geometric packing conflicts to avoid defects

The paper shows how mouse embryonic kidney epithelium resolves geometric packing conflicts through internally generated tensions to avoid defects.

Fgf8 promotes survival of nephron progenitors by regulating BAX/BAK-mediated apoptosis

This study shows that FGF8 promotes nephron progenitor survival by regulating BAX/BAK-mediated apoptosis, partially rescuing kidney development in Fgf8 mutants.

Hnf1b renal expression directed by a distal enhancer responsive to Pax8

The paper identifies a distal enhancer, CNS1, that drives Hnf1b renal expression and is responsive to Pax8 in Xenopus and mammalian renal cells.

FGF8 induces chemokinesis and regulates condensation of mouse nephron progenitor cells

This study shows FGF8 promotes chemokinesis in mouse nephron progenitor cells, facilitating their condensation around ureteric buds.

The extracellular matrix protein fibronectin modulates metanephric kidney development

This study shows fibronectin regulates metanephric kidney development by influencing branching morphogenesis and glomerulogenesis in mice and humans.

Interstitial Notch signaling regulates nephron development via the Gata3-Renin axis in the mouse kidney

This study shows that interstitial Notch signaling regulates proximal tubule development in mouse kidneys through the Gata3-Renin axis.

Single-cell chromatin and gene-regulatory dynamics of mouse nephron progenitors

The paper uses single-cell chromatin accessibility and gene expression data to study regulatory dynamics in mouse nephron progenitors, identifying cell-type-specific cis-regulatory elements and transcription factors involved in fate decisions.

Chromatin accessibility and microRNA expression in nephron progenitor cells during kidney development

The paper characterizes chromatin accessibility and microRNA expression in nephron progenitor cells during kidney development, identifying changes in regulatory elements and microRNAs associated with key biological processes.

Haploinsufficiency of the mouse Tshz3 gene leads to kidney dysfunction

This study shows that Tshz3 haploinsufficiency in mice causes kidney structural, molecular, and functional abnormalities.

Revisiting The Role of Notch in Nephron Segmentation: Notch is required for proximal, not distal fate selection during mouse and human nephrogenesis

The paper investigates Notch signaling's role in nephron segmentation, finding it promotes proximal fate selection while not affecting distal fate in mouse and human kidney development.

Computational Modelling of Cell Movements and Aggregations during Kidney Organogenesis

This paper uses a Cellular Potts Model to simulate cell movement and aggregation during kidney development, showing that chemoattractant secretion and cell adhesion differences drive NP cell patterning.

Single cell RNA sequencing reveals differential cell cycle activity in key cell populations during nephrogenesis

This study uses single-cell RNA sequencing to identify differential cell cycle activity in nephron progenitors during mouse kidney development, highlighting Birc5 as a potential key molecule in nephron patterning.

Age-Dependent Changes in the Progenitor Translatome Coordinated in part by Tsc1 Increase Perception of Signaling Inputs to End Nephrogenesis

The paper shows age-dependent changes in nephron progenitor translation and signaling that influence nephrogenesis timing, with Tsc1 affecting Wnt signaling balance.

Omics profiling identifies MAPK/ERK pathway as a gatekeeper of nephron progenitor metabolism

The paper identifies the MAPK/ERK pathway as critical for nephron progenitor metabolism, showing its role in energy and nucleotide biosynthesis, glycolysis, and proline metabolism.

osr1 couples intermediate mesoderm cell fate with temporal dynamics of vessel progenitor cell differentiation

The paper shows that osr1 regulates intermediate mesoderm formation and delays vessel progenitor differentiation in zebrafish.

3D mapping reveals a complex and transient interstitial matrix during murine renal development

This paper maps the 3D dynamics of the extracellular matrix during murine kidney development, identifying transient changes in interstitial matrix proteins and their spatial organization.

Temporally and Spatially Regulated Collagen XVIII Isoforms Impact Ureteric Patterning Through Their TSP1-like Domain

This study shows that specific collagen XVIII isoforms regulate ureteric branching morphogenesis through their TSP1-like domain in kidney development.

Reconstruction of the urinary tract at the appropriate time reduces fibrosis of the metanephros in rats as judged by imaging

This study evaluates the growth of transplanted metanephros in rats using imaging and finds that optimizing urinary tract reconstruction timing reduces fibrosis.

osr1 maintains renal progenitors and regulates podocyte development by promoting wnt2ba through antagonism of hand2

This study identifies Osr1's role in maintaining renal progenitors and regulating podocyte development through Wnt2ba expression, revealing its antagonistic relationship with Hand2.

Kctd15 regulates nephron segment development by repressing Tfap2a activity

This study shows that Kctd15 paralogs restrict distal nephron segment development by repressing Tfap2a activity in zebrafish.

Hnf4a is required for the development of Cdh6-expressing progenitors into proximal tubules in the mouse kidney

This study shows Hnf4a is essential for Cdh6-expressing progenitors to develop into proximal tubules in the mouse kidney by regulating genes involved in reabsorption.

Nephron progenitor maintenance is controlled through FGFs and Sprouty1 Interaction

This study identifies Sprouty1's role in regulating FGF signaling to maintain nephron progenitors, showing that Spry1 haploinsufficiency rescues renal agenesis and progenitor depletion caused by Fgf9/Fgf20 loss.

Tumor-free elongation of mammalian nephrogenesis by excess fetal GDNF

This study shows that excess fetal GDNF can prolong nephrogenesis in postnatal mouse kidneys without increasing tumor risk.

Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids

This study shows that asynchronous mixing of kidney progenitor cells in organoids enhances nephrogenesis and functional features, but stromal overgrowth limits long-term study.

Generation of kidney ureteric bud and collecting duct organoids that recapitulate kidney branching morphogenesis

The paper generates kidney collecting duct organoids from ureteric bud progenitors and stem cells to study development and disease of the collecting system.

Characterization of interstitial heterogeneity in the developing kidney

The paper characterizes the heterogeneity of the interstitium during kidney development and identifies distinct cell states and roles for beta-catenin in medullary interstitial cells.

Paracrine and autocrine R-spondin signalling is essential for the maintenance and differentiation of renal stem cells

This study shows that RSPO1 and RSPO3 are essential for WNT/β-catenin signaling in kidney development, with their deletion causing loss of renal progenitors and failure of MET.