Topic · Rheumatology · Medicine
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
6 papers
Janell L.M. Smith, Kamaryn Tanner, Jack Devine, Anna Sophia Monzel, Taivan Batjargal, Maxwell Z. Wilson, Alan Arthur Cohen, Martin A. Picard
The paper develops an ISRGDF15 index to quantify the GDF15 arm of the ISR in human cells and tissues, showing its upregulation in specific tissues and correlation with age.
Communications Biology · May 27, 2026Peer-reviewedCell Biology
Cynthia C. Liu, Caroline Trumpff, Qiuhan Huang, Robert‐Paul Juster, Martin A. Picard
This study examines salivary GDF15 levels and their associations with biopsychosocial factors and stress reactivity in healthy adults.
Brain Behavior and Immunity · Mar 4, 2025Peer-reviewedPhysiology
Cecilia Hes, Luting Gui, Alexandre Bay, Fernando Alvarez, Pierce Katz, Tanushree Paul, Nadejda Bozadjieva-Kramer, Randy J. Seeley, Ciriaco A. Piccirillo, Paul V. Sabatini
The paper identifies GFRAL expression in the caudal brainstem and shows minimal expression in peripheral tissues in mice and humans.
Molecular Metabolism · Nov 26, 2024Peer-reviewedMolecular Biology
Molly C. Mulcahy, Noura El Habbal, JeAnna R. Redd, Haijing Sun, Brigid Ellen Gregg, Dave Bridges
This study examines the role of GDF15 in pregnancy and neonatal outcomes using a knockout mouse model, finding no major effects on body weight or survival.
Endocrinology · Oct 22, 2024Peer-reviewedPhysiology
Jyoti Asundi, Chunlian Zhang, Diana L. Donnelly‐Roberts, Jose Zavala‐Solorio, Malleswari Challagundla, Caitlin F. Connelly, Christina Boch, Jun Chen, Mario Richter, Mohammad Mehdi Maneshi, Andrew M. Swensen, Lauren LeBon, Raphael Schiffmann, Subhabrata Sanyal, Carmela Sidrauski, , Amos Baruch
This study identifies GDF15 as a biomarker of the Integrated Stress Response in the CNS, showing its correlation with ISR activity in both animal models and human patients.
CNS Neuroscience & Therapeutics · Feb 1, 2024Peer-reviewedNeuroscience
Yanislava Karusheva, Matthew Ratcliff, Alexander Mörseburg, Peter Barker, Audrey Melvin, Naveed A. Sattar, Keith Burling, Anna Backmark, Robert G. Roth, Lutz Jermutus, Esther Guiu‐Jurado, Matthias Blüher, Paul I. Welsh, Marko Hyvönen, Stephen O’Rahilly
The study shows that the H202D variant in GDF-15 does not affect its bioactivity but causes underreporting in R&D immunoassays, with correction equations provided.
The Journal of Applied Laboratory Medicine · Jul 7, 2022Peer-reviewedGenetic & Genomic Medicine