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This study identifies two monoclonal antibodies from convalescent patients that target conserved cryptic epitopes on SARS-CoV-2, enabling broad neutralization against all variants including Omicron subvariants.

This study shows that Ate1 induces cell death via a mitochondria-dependent pathway, independent of cytosolic degradation pathways and mitochondrial ROS.

The paper examines how cysteine mutations in FBLN3 affect its structure, secretion, and stress response, revealing varied biochemical outcomes and potential disease implications.

This study evaluates whether chromatographic performance affects proteome coverage under high-speed data acquisition, finding that proteome depth is now more influenced by mass spectrometry than chromatography.

This study presents cryo-EM structures of GPR99/OXGR1 with oxoglutarate and LTE4, revealing distinct binding sites and signaling mechanisms.

This study shows that N-terminal acetylation of SOD1 increases amyloid formation rate without destabilizing the apo-state structure.

This study examines the metabolic changes in CysLTR1 knockout mice using metabolomics of BALF, revealing disruptions in glucose, lipid, and microbial metabolism.

This study reports the structure of the AMT complex bound to OCR protein, revealing its substrate binding mechanism and conformational changes during 6mA methylation.

The paper examines temperature-induced structural changes in insulin, revealing dynamic shifts that impact thermal stability and provide insights for developing thermostable insulin formulations.

The paper identifies non-canonical nitrous oxide production pathways in a lake through isotope analysis and incubation experiments, showing bacterial denitrification as dominant with contributions from chemo- and fungal denitrification.

This study uses molecular dynamics simulations to show that increasing cholesterol concentrations reduces amyloid-induced membrane poration.

This study identifies and characterizes 12 RNA modifications in plants from bryophytes to flowering plants using HILIC-MS/MS, revealing their evolutionary patterns and roles in auxin responses.

This study shows HMGB1 counteracts linker histone H1 by distorting nucleosomal DNA and contacting H1's C-terminal tail, enabling co-occupancy and dynamic chromatin states.

This study uses computational simulations to show that preserving reactive conformations with well-positioned residues is critical for catalytic efficiency in CARNMT1, as demonstrated by comparing wild-type and mutant enzymes.

The paper develops a high-throughput method to identify fluoroprobes that distinguish between tau fibril polymorphs using paDSF and chemical screening.

AtomWorks, a modular atom-level data framework, trains structure prediction and design models; the resulting RF3 improves chirality handling and performs between AF3 and Boltz.

This study identifies the Hb group's interaction with the hydrophobic pocket as sufficient to induce gate opening in archaeal 20S proteasomes, revealing a mechanism for proteasome activation.

This study compares the potency of thirteen RAF inhibitors against ARAF, BRAF, and CRAF isoforms, revealing differences in inhibitor selectivity and mechanism.

This study uses integrated top-down mass spectrometry to reveal structural heterogeneity in AMPK proteoform-ligand complexes, uncovering new insights into kinase regulation.

The paper identifies BCL2 proteins as co-receptors for CUL5WSB2 to target BIM for degradation, revealing a novel mechanism in apoptosis regulation with therapeutic implications for neuroblastomas and cancers.