Discover, rate, and verify biology preprints.

EEG Foundation Model Improves Online Directional Motor Imagery Brain-computer Interface Control

This paper introduces an EEG foundation model that improves online directional motor imagery BCI control, achieving higher accuracy and faster task completion in human participants.

Hydrogel-Embedded Precision-Cut Lung Slices Recapitulate Fibrotic Gene Expression and Enable Therapeutic Response Evaluation

This paper develops a hydrogel-embedded PCLS model to study pulmonary fibrosis, showing prolonged viability and matching fibrotic gene expression patterns in human tissue.

Orthogonal Transposons for Iterative Genome Engineering of Mammalian Cells.

This paper introduces a method using orthogonal transposons to iteratively modify the CHO genome for therapeutic development, achieving stable and predictable genetic modifications.

Stabilized gp120-specific CD4 for next-generation HIV-1 inhibitors

This paper develops a gp120-specific CD4 variant (gCD4) that improves thermostability, reduces off-target class II MHC binding, and enhances HIV-1 neutralization compared to existing CD4-Ig biologics.

Ultrasound Activated Nanobubbles Induce Durable Systemic Antitumor Immunity

This paper demonstrates that ultrasound-activated nanobubbles enhance antitumor immunity by restoring extracellular matrix elasticity and re-engaging immune cells in breast cancer models.

Lipid-MOF Colloidosomes for Multimodal Encapsulation and Environmental Remediation

This paper develops lipid-MOF colloidosomes for multimodal encapsulation and environmental remediation, showing high stability and efficient pollutant removal.

Deep-learning-enabled morphodynamic analysis of drug responses in a biomimetic fibrin-based 3D glioblastoma invasion model

This paper develops a 3D glioblastoma model with deep learning to predict drug responses and invasion patterns.

Micro-to-Macro Scale Hydrogel Microchannel Networks by Twisted Wire Templating

This paper introduces a method to create multiscale hydrogel vascular networks using twisted wire templating, achieving seamless transitions from macro- to micro-scale vessels.

Hydrogel Fiber Endomicroscopy

This paper introduces HYFEN, a hydrogel-based endomicroscopy platform that enables flexible, biocompatible, and subcellular-scale fluorescence imaging with improved resolution and performance compared to conventional silica-based fibers.

A Multivalent Peptide-Polymer Conjugate Material Mimics STING to Therapeutically Activate Innate Immune Signaling

This paper develops a multivalent peptide-polymer conjugate that mimics STING to activate innate immune signaling and shows tumor regression in ovarian cancer models.

Non-invasive MRI mapping of tissue-CSF water exchange reveals glymphatic fluid movement in live human cortex

This study uses MRI to show glymphatic fluid movement in live human cortex, finding reduced exchange in Alzheimer's disease.

Decoding Immunomodulatory Hydrogels for Arthritis: Comparative Insights from Predictive Machine Learning and Large Language Models

The paper uses machine learning to analyze hydrogel formulations for arthritis, identifying key design factors and showing improved predictive accuracy over classical methods.

Fluorogenic speed-optimized DNA-PAINT probes enable super-resolution imaging of whole cells

This paper introduces fluorogenic DNA-PAINT probes that improve super-resolution imaging speed and signal-to-background ratio in cells.

Discovery of a Linked Constellation of Gene Expression Revealed by Local Editing of Fibroblasts in Tumors

The paper uses local gene editing in mouse tumor models to discover a novel fibroblast state and its impact on the tumor microenvironment.

Influenza Virus Infection of an Immunocompetent Organotypic Model of the Human Respiratory Mucosa

The paper develops an immunocompetent 3D model of human respiratory mucosa to study influenza virus infection and immune responses.

Deep-tissue absolute force spectroscopy with sub-piconewton precision

This paper introduces a method for absolute force measurements in living tissues with sub-piconewton precision, validated in Drosophila pupae and embryos.

DAMP-inducing Peptide Nanofibers and PAMP Combination Adjuvants Boost Functional Lung Tissue-resident Memory CD4+ T Cell Responses

This study shows that combining DAMP-inducing peptide nanofibers with a PAMP enhances lung-resident memory CD4+ T cell responses, improving protection against TB and respiratory diseases.

Mechanical and morphological effects of intervertebral disc injury: a systematic review of in vivo animal studies

This paper reviews in vivo animal studies on intervertebral disc injury, finding significant mechanical and morphological changes, with Youngs modulus as a sensitive marker of degeneration.

Subconcussive preconditioning prevents microglial morphology changes and improves cognitive outcomes in mice

This study shows that subconcussive impacts before concussion reduce microglial changes and cognitive deficits in mice, but only if given within 2 minutes of injury.

OpenMebius2: GUI-based software for 13C-metabolic flux analysis with tracer labeling pattern suggestions for accurate flux predictions

OpenMebius2 is a GUI-based software for 13C-metabolic flux analysis that suggests tracer labeling patterns to improve flux prediction accuracy.