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Acoustically patterned hepatic lobule-like units for vascularized artificial liver

This paper develops an ultrasonic method to create vascularized hepatic units with improved function and integration in mice.

Spatiotemporal Control of Genetic and Epigenetic Editing through Covalent Tethering of CRISPR Nanoparticles to Zwitterionic Microgels

This paper introduces a method to covalently tether CRISPR nanoparticles to microgels for sustained and localized gene editing in human cells.

Removal of Hg and Cu from raw gold-mine tailings by microalgae- and bacteria-augmented microbial fuel cells: Effects of bio-augmentation, diurnal cycling and operational faults

This study evaluates the effectiveness of microbial fuel cells in removing mercury and copper from gold-mine tailings, finding that physicochemical processes, not algal bio-augmentation, drive contaminant removal.

CAF contractility controls collagen stiffness through history-dependent competition between mechanical and proteolytic remodeling

This study shows that CAF contractility dynamically regulates collagen stiffness through competition between mechanical and proteolytic remodeling, with outcomes dependent on treatment duration.

CORE: Deterministic alignment for bias-free organoid histology

This paper introduces CORE, a method to align organoid specimens on a shared plane to eliminate sampling bias and enable reproducible histology.

Electrophysiological dependent antiarrhythmic drug response in population-based models of paroxysmal atrial fibrillation

This study shows that antiarrhythmic drug efficacy in atrial fibrillation depends on patient-specific electrophysiological substrates and rotor dynamics, with drug-induced frequency reduction being a key mechanism.

Code-Multiplexed Multi-Frequency Impedance Cytometry with a Unified Deep-Unfolding Network

This paper develops a deep-unfolding network for code-multiplexed, multi-frequency impedance cytometry to resolve signal overlaps and enable label-free single-cell analysis.

Older adults do not have a higher metabolic cost than younger adults in outdoor overground walking.

Across seven pace-controlled outdoor overground speeds, healthy older adults (n=11) showed no higher gross or net walking cost than younger adults (n=16), trending lower instead.

A reduced glycosaminoglycan-linked residual-strain model captures regional opening angle changes after depletion in the porcine thoracic aorta

The paper develops a model to explain regional changes in aortic opening angles after GAG depletion, showing a common FCD-linked preferred-stretch contribution across regions.

Cascaded Nano-ring Dialyzer for Continuous Regenerative Peritoneal Dialysis

This paper develops a continuous regenerative peritoneal dialysis system using cascaded nano-ring dialyzers, achieving toxin removal in a canine model.

Quantifying the Effect of Trunk Postural Control on Reaching with Progressive Shoulder Abduction Loading in Hemiparetic Stroke

This study investigates how active trunk control affects reaching function in stroke patients under shoulder abduction loading, finding that trunk control reduces reaching distance but the flexion synergy is the main factor.

The Tissue Engineering Grail: Seamless Biofabrication of Scaffold-free Hollow Constructs

This paper introduces a method to create scaffold-free hollow tissue constructs using anchored cell sheet engineering, enabling the formation of tubular and spherical structures with mechanical stability and biological function.

A human engineered mini-heart platform for mimicking ventricular pump function

This paper develops a human mini-heart model that mimics ventricular pump function through sacrificial molding and bioreactor technology, enabling non-invasive hemodynamic measurements and drug response testing.

Paired-surface spatial mechanomics links tissue stiffness maps to spatial transcriptomics

Mapping the Fascicular Morphology and Organization of the Human Sciatic Nerve via High-Resolution MicroCT Imaging

This paper uses high-resolution microCT imaging to map fascicular organization in the human sciatic nerve, revealing asymmetry in branch lengths and fascicle distribution, which informs neuroprosthetic design.

Computational and Experimental Evaluation of a Flow-Conditioning Anastomotic Device for Arteriovenous Fistula Maturation

This study evaluates a flow-conditioning anastomotic device to improve AVF hemodynamics and reduce endothelial injury by normalizing wall shear stress.

Dosing and Delivery of Bacteriophage Therapy In a Murine Wound Infection Model

This study evaluates phage therapy dosing and delivery in a mouse wound infection model, finding topical high-dose repeated administration effective and developing a sustained-release hydrogel system.

Engineering human myelin microphysiological systems for testing patient treatment response in multiple sclerosis

This paper develops a human myelin microphysiological system to test treatment responses in multiple sclerosis patients, showing differential demyelination and immune responses between patient groups.

Latent generative search unlocks de novo design of untapped biomolecular interactions at scale

Reward-guided inference-time search over the Proteína-Complexa sequence-structure codesign model yields validated binders across 127 targets, kinases and a free carbohydrate, with codesigned sequences outperforming ProteinMPNN redesign.

Sprayable in Situ Forming PEG Hydrogels for Intranasal Drug Delivery

This paper develops a PEG-based hydrogel for intranasal drug delivery that forms in situ without physiological triggers, improving drug residence time and bioavailability.