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Contrast-Free Microvascular and Functional Brain Imaging by Sparse Deconvolution of Ultrafast Power Doppler

This paper introduces a sparse deconvolution framework to enhance resolution in ultrafast power Doppler ultrasound imaging, improving microvascular and functional brain imaging without contrast agents.

SVD-SN2N: Self-Inspired Noise2Noise Learning for Denoising Log-Compressed SVD-Filtered Ultrasound Imaging

SVD-SN2N improves denoising of SVD-filtered ultrasound images by converting multiplicative speckle to additive noise, enhancing SNR and vessel resolution without requiring clean references or raw data.

Zwitterionic polymer coating enabled chronic dopamine sensing and electrophysiology recording in free-moving mice

This paper develops a zwitterionic polymer coating to enable chronic dopamine sensing and electrophysiology recording in freely moving mice over four weeks.

Nonviral, ultrasound-triggered gene delivery platform via gas-core cationic nanobubbles

This paper develops a nonviral, ultrasound-triggered gene delivery platform using cationic nanobubbles that achieve efficient, site-specific gene expression in vitro and in vivo.

Unravelling the distinct phenotype and mechanosensitive properties of different tendon cell populations.

The paper identifies and characterizes a new tendon cell population in the interfascicular matrix, showing its mechanosensitive properties and potential for therapeutic applications.

Modular click-chemistry-based engineering minimally perturbs CRISPR ribonucleoprotein formation for genome imaging applications

This paper develops a modular click-chemistry strategy to modify CRISPR RNPs without disrupting their formation, enhancing DNA accessibility and enabling genome imaging.

Combined Cartilage Thickness and Mechanical Property Mismatch Drives Local Strain Amplification at the Patellar Osteochondral Allograft Interface

This study shows that mismatch in cartilage thickness and mechanical properties at the patellar osteochondral allograft interface leads to localized high-strain regions that may cause graft failure.

DINOCT: robust skin surface localization for robotic noncontact dynamic optical coherence elastography

DINOCT improves skin surface localization in noncontact OCE by combining self-supervised pretraining with DINO and iBOT objectives, achieving high accuracy and robustness to artifacts.

Functional alignment of protein language models via reinforcement learning

This paper introduces RLXF, a framework that aligns protein language models with experimental functional goals, improving the generation of high-functioning protein variants.

Acoustofluidic Active Flow Sculpting Enables Dynamic, Reconfigurable Cross-Sectional Patterning

This paper introduces ActiSculpt, an acoustofluidic platform that enables dynamic, reconfigurable cross-sectional patterning of soft materials in continuous flow.

Multiphase capillarics for structurally pre-programmed sequential and parallel operations of high and low cohesion liquids

This paper introduces multiphase capillaric circuits that enable sequential and parallel handling of high and low cohesion liquids through specialized components.

Modular Surface Engineering of Feline Parvovirus Virus-Like Particles for Antigen Presentation and Receptor-Mediated Cell Targeting

This study produces and functionalizes feline parvovirus VLPs using click-chemistry for antigen presentation and receptor-mediated targeting.

TLS-Sim: An Open-Source Toolkit for Individualized Transcranial Light Stimulation Modeling with Deep-Learning-Accelerated Simulation

TLS-Sim provides a toolkit for individualized transcranial light stimulation modeling using deep-learning-accelerated Monte Carlo simulations to improve efficiency and accuracy.

Machine-learning-guided enzyme discovery and redox-system engineering for efficient production of the nylon monomer methyl 12-aminododecanoate in Escherichia coli

This study uses machine learning to discover enzymes for producing ADAME in E. coli, achieving a 5.6-fold improvement over existing methods.

Experimental Assessment of Iris Water Content and Sex Differences in Mature Rabbits

The paper experimentally measures iris water content and sex differences in rabbits, finding higher water content in males and minimal PBS effect on females.

Robust cellular transformations of PET deconstruction products by import of glycol esters

This study demonstrates that E. coli can efficiently uptake and convert PET deconstruction products into upcycled reduction products with high yields.

The influence of muscle mass on the coordination required for efficient movement

This study investigates how muscle coordination changes with muscle size during cycling by simulating metabolic cost minimization across scaled muscle models.

Phenotypic screens identify biologic regulators of nanoparticle uptake in diffuse midline glioma

The paper identifies biologic regulators of nanoparticle uptake in diffuse midline glioma using CRISPR screens and functional assays, finding CTNNB1 and pathway members as key modulators.

Information processing-like phenotype of human brain organoids

This study quantifies information-processing-like properties of human cortical organoids using a functional phenotyping framework, linking network function to disease-related mutations and pharmacological perturbations.

Medicament identity rather than total loading governs the morphology of electrospun poly(vinylpyrrolidone) nanofibers for regenerative endodontics: a machine learning analysis of a failure-inclusive dataset

The paper uses machine learning to analyze a dataset of electrospun nanofibers, finding that medicament identity, not total loading, better predicts fiber morphology in regenerative endodontics.