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Fungal microbial enrichment method enables fungal metagenomics directly from human clinical samples

This paper introduces fMEM, a fungal microbial enrichment method that enables direct fungal metagenomic analysis from clinical samples, recovering MAGs with high completeness and resolving clinically relevant genes.

Distributed resonant coupling enables high efficiency power transfer to mm-scale bioelectronics

This paper introduces distributed resonant coupling (DRC) for efficient wireless power transfer to mm-scale bioelectronics, achieving high power transfer efficiencies in various orientations and tissue conditions.

Nanobubble-Based Ultrasound Localization Microscopy through Interactive Adaptive Processing

This paper demonstrates that nanobubbles can be used as contrast agents in ultrasound localization microscopy, achieving comparable flow measurements to microbubbles despite their weaker acoustic response.

Regulators of ECM Structure Enable Functional Adaptation to Tensile Loading in Tendon Explants

This study investigates how mechanical strain affects tendon ECM remodeling, finding that increased strain promotes anabolic remodeling via TGF-β and IL-6 signaling, while decreased strain leads to catabolic changes.

Impact of multi-echo ICA modeling decisions on motor-task fMRI analysis

This study compares ME-ICA denoising approaches in motor-task fMRI, finding that a conservative method better preserves task-related signal while reducing noise in high-motion scenarios.

Combinatorial screening of biological degrader modules identifies heterobifunctional molecules that efficiently destroy MYC, leading to rapid tumour cell death in vitro and in vivo

CRISPR-Associated Transposases Enable Programmable DNA Integration in Plants

This study demonstrates the use of CRISPR-associated transposases for programmable DNA integration in plants, achieving efficient chromosomal and episomal integration in Arabidopsis and Nicotiana benthamiana.

The overlooked role of muscle regeneration failure in post-implantation complications: a thorough investigation into mechanisms of recurrent urethral stricture

This study investigates muscle regeneration failure in urethral reconstruction, finding that incomplete muscle regeneration leads to profibrotic responses and recurrent stricture.

Increased Interstitial Flow and Elastic Lamina Degradation Precede Aortic Dissection

This study shows that increased interstitial flow and elastic lamina degradation occur before aortic dissection in a mouse model.

Dynamic Stiffening to Improve Vasculogenesis of hiPSC-Derived Endothelial Progenitors

This study shows that dynamically adjusting hydrogel stiffness during vasculogenesis improves vascular network formation, while late stiffening disrupts it, with effects mediated by FAK and Rho kinase.

MEMS-Based Ultrasonic Energy Harvesting Platform Enabling Sustained In Vivo Operation of Implantable Microdevices

This paper presents a MEMS-based ultrasonic energy-harvesting platform for implantable microdevices, demonstrating sustained in vivo operation and efficient energy storage.

Shape, Shrink, Spheroid: A DIY High-throughput Spheroid Generation Device

This paper introduces a low-cost DIY device for high-throughput generation of uniform-sized spheroids, validated with multiple cell lines and drug testing.

Brain-computer interface training fosters perceptual skills to detect errors

This study shows that real-time feedback on error-related potentials during perceptual training enhances error detection ability, outperforming conventional feedback methods.

Hydrodynamic dispersion drives viral-cellular contact for gene delivery in porous media

The paper shows that hydrodynamic dispersion in porous media enhances viral-cellular collisions, improving transduction efficiency by overcoming sedimentation-diffusion limitations.

Palliative Irradiation Affects Temporal Degradation of Rodent Vertebral Bone Mechanics, Architecture, and Composition

This study evaluates the longitudinal effects of high-dose irradiation on vertebral bone mechanics, architecture, and composition in rats, finding progressive deterioration in mechanical properties and trabecular structure.

High-Density Wild-Type IL-2 Nanoparticles Preferentially Enhance CD8⁺ T-Cell Expansion and Reprogram the Tumor Microenvironment

This paper develops IL2-NP nanoparticles that enhance CD8 T-cell expansion and reprogram the tumor microenvironment, showing efficacy in multiple cancer models.

Physiological limits of localized hypothermia in the human cochlea: The role of vascular heat transport

This study evaluates how blood flow affects cochlear temperature during localized hypothermia using experimental and computational methods, finding that vascular heat transport significantly influences cooling effectiveness.

Integrating vascular and hypertrophic cartilage microtissues to fabricatescaled-up grafts for endochondral bone tissue engineering

This study develops a biofabrication strategy combining vascular and hypertrophic cartilage microtissues with 3D-printed scaffolds to create scalable, prevascularized grafts for endochondral bone repair.

A Minimally Invasiveness Hybrid Brain-Computer Interface: A Distributed, Scalable and Evolvable Architecture for Whole Brain Access

This paper introduces a minimally invasive hybrid brain-computer interface that improves signal quality and scalability over existing non-invasive and invasive systems.

Lipid nanoparticle co-delivery of mRNA and a small molecule drug for oral cancer chemoimmunotherapy

This paper develops a lipid nanoparticle co-delivering mRNA and a small molecule drug to treat oral cancer by enhancing chemotherapy and reshaping the tumor microenvironment.