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Metabolic collapse as a mechanism of developmental regression: convergent evidence from Kleefstra syndrome FDG-PET/CT imaging and Drosophila modelling

This study links metabolic vulnerability and sleep disturbances in Kleefstra syndrome using FDG-PET/CT imaging and Drosophila models.

Genetic parameters and genotype-by-diet interactions forgrowth traits in Australian black soldier fly larvae: Implicationsfor selective breeding

This study estimates genetic parameters and genotype-by-diet interactions for growth traits in black soldier fly larvae, finding moderate heritability and significant dominance effects.

Enhancer buffering protects dosage-sensitive housekeeping genes during vulnerable developmental transitions

TCOF1 dosage is limiting for transitional human neural crest cells; its enhancers buffer promoter output against MYC fluctuations rather than amplifying it, a pattern seen across 14 dosage-sensitive promoters.

Sperm-specific fertility factors SMZ-1/2 promote FB-MO biogenesis and MSP filament assembly in C. elegans

This study identifies SMZ-1/2 as PDZ proteins that initiate MSP filament assembly and FB-MO biogenesis in C. elegans sperm by coupling kinase signaling to organelle formation.

Starve-Feed Cycles Direct Quiescence to Proliferation Transitions in Drosophila Follicle Stem Cells via Transcriptional Regulation

The paper identifies novel regulators of quiescence-to-proliferation transitions in Drosophila follicle stem cells by analyzing gene expression changes during feeding.

The QxxR Motif of RNA Helicase Me31B Is Essential for Drosophila Female Fertility and Germline Development

This study investigates the role of the QxxR motif in Drosophila Me31B, showing that a mutation in this motif causes female sterility and germline defects without altering protein abundance or global transcriptome profiles.

Constitutive PDGFRb activation drives connective tissue overgrowth through STAT5-IGF1 signaling

This study identifies STAT5-IGF1 signaling as a pathway driven by constitutive PDGFRb activation that causes connective tissue overgrowth in mice, with implications for human disease.

General moment closure for the neutral two-locus Wright-Fisher dynamics

This paper introduces a method to close the system of equations for moment dynamics in population genetics under recombination, enabling more accurate numerical computations of genetic diversity and linkage statistics.

Epigenomic Landscape of Oak (Quercus robur) across Seasons and Generations

This study maps DNA methylation in oak trees across seasons and generations, revealing seasonal reprogramming and generational differences in methylation patterns.

Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits

Genome-scale CRISPRi perturb-seq in 22 million primary human CD4+ T cells maps stimulation-specific regulators and links perturbation signatures to T cell states and autoimmune genetics.

Sequence architecture shapes human allele frequencies through ectopic gene conversion

The paper shows that ectopic gene conversion, influenced by genome architecture, significantly shapes human allele frequencies, affecting both rare and common variants.

Inherited DNA damage generates multi-allelic mutations in C. elegans

The paper shows that DNA lesions in C. elegans can be inherited and generate multi-allelic mutations across generations.

Modeling population control via tunable sex ratio distorter gene drives in Aedes aegypti, an arboviral vector with homomorphic sex chromosomes

The paper develops a mathematical framework to model sex ratio distorter gene drives in Aedes aegypti, showing how they can be tuned for efficient population suppression with minimal impact on neighboring species.

High temperature-induced diapause transiently primes progeny for dauer formation in C. elegans.

This study shows that high temperature-induced diapause in C. elegans temporarily enhances progeny dauer formation upon re-exposure to heat, while preserving reproductive capacity.

Locus-specific gene-context interactions improve polygenic prediction

This paper introduces PGSC, a polygenic score framework that incorporates locus-specific gene-context interactions, showing improved prediction across multiple traits and ancestries.

The Genomic Landscape of Post-Black Death Epidemics in Northern Europe and the Caucasus

Twenty-three new Yersinia pestis genomes from Scandinavia, the Netherlands, Iceland and Armenia extend the Second Plague Pandemic phylogeny, with the first Icelandic plague genome and eastward-spreading pestis secunda strains.

Identification of osteopontin as a positional and functional candidate gene for cardiac hypertrophy in the SHRSP rat

The paper identifies osteopontin (Spp1) as a positional and functional candidate gene for cardiac hypertrophy in SHRSP rats through congenic strain analysis and transcriptome profiling.

A simulation-based method for genotype-environment association analysis

This paper introduces SimGEA, a simulation-based method for genotype-environment association analysis that controls false discovery rates while maintaining statistical power.

The Drosophila Secretome

A tiered catalogue of 5,280 Drosophila genes encoding putative secreted proteins (1,802 high-confidence) with a web portal; these genes are less conserved, more tissue-restricted and disproportionately down-regulated with age.

Evolution of transposons as controlling elements

This study shows that transposases can act as transcriptional regulators and evolved into transcription factors through loss of catalytic activity.